Vitamin B6 Deficiency Promotes Loss of Heterozygosity (LOH) at the <i>Drosophila</i> <i>warts</i> (<i>wts</i>) Locus

Vitamin B6 Deficiency Promotes Loss of Heterozygosity (LOH) at the <i>Drosophila</i> <i>warts</i> (<i>wts</i>) Locus

The active form of vitamin B6, pyridoxal 5′-phosphate (PLP), is a cofactor for more than 200 enzymes involved in many metabolic pathways. Moreover, PLP has antioxidant properties and quenches the reactive oxygen species (ROS). Accordingly, PLP deficiency causes chromosome aberrations in <i>Dro...

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Bibliographic Details
Main Authors: Eleonora Gnocchini, Eleonora Pilesi, Ludovica Schiano, Fiammetta Vernì
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:International Journal of Molecular Sciences
Subjects:
pyridoxal 5′ phosphate (PLP)
vitamin B6
loss of heterozygosity (LOH)
mitotic recombination
<i>warts</i>
<i>Drosophila</i>
Online Access:https://www.mdpi.com/1422-0067/23/11/6087

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