Cell Line Techniques and Gene Editing Tools for Antibody Production: A Review
The present day modern formulation practices for drugs are based on newer tools and techniques toward effective utilization. The methods of antibody formulations are to be revolutionized based on techniques of cell engineering and gene editing. In the present review, we have discussed innovations in...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-06-01
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| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fphar.2018.00630/full |
| _version_ | 1818924889617203200 |
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| author | Arun K. Dangi Rajeshwari Sinha Shailja Dwivedi Sanjeev K. Gupta Pratyoosh Shukla |
| author_facet | Arun K. Dangi Rajeshwari Sinha Shailja Dwivedi Sanjeev K. Gupta Pratyoosh Shukla |
| author_sort | Arun K. Dangi |
| collection | DOAJ |
| description | The present day modern formulation practices for drugs are based on newer tools and techniques toward effective utilization. The methods of antibody formulations are to be revolutionized based on techniques of cell engineering and gene editing. In the present review, we have discussed innovations in cell engineering toward production of novel antibodies for therapeutic applications. Moreover, this review deciphers the use of RNAi, ribozyme engineering, CRISPR-Cas-based techniques for better strategies for antibody production. Overall, this review describes the multidisciplinary aspects of the production of therapeutic proteins that has gained more attention due to its increasing demand. |
| first_indexed | 2024-12-20T02:32:30Z |
| format | Article |
| id | doaj.art-a50a182f921b4abdbf6fb56babe35ae6 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-20T02:32:30Z |
| publishDate | 2018-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-a50a182f921b4abdbf6fb56babe35ae62022-12-21T19:56:32ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122018-06-01910.3389/fphar.2018.00630379411Cell Line Techniques and Gene Editing Tools for Antibody Production: A ReviewArun K. Dangi0Rajeshwari Sinha1Shailja Dwivedi2Sanjeev K. Gupta3Pratyoosh Shukla4Enzyme Technology and Protein Bioinformatics Laboratory, Department of Microbiology, Maharshi Dayanand University, Rohtak, IndiaIndependent Researcher, New Delhi, IndiaAdvanced Biotech Lab, Ipca Laboratories Limited, Mumbai, IndiaAdvanced Biotech Lab, Ipca Laboratories Limited, Mumbai, IndiaEnzyme Technology and Protein Bioinformatics Laboratory, Department of Microbiology, Maharshi Dayanand University, Rohtak, IndiaThe present day modern formulation practices for drugs are based on newer tools and techniques toward effective utilization. The methods of antibody formulations are to be revolutionized based on techniques of cell engineering and gene editing. In the present review, we have discussed innovations in cell engineering toward production of novel antibodies for therapeutic applications. Moreover, this review deciphers the use of RNAi, ribozyme engineering, CRISPR-Cas-based techniques for better strategies for antibody production. Overall, this review describes the multidisciplinary aspects of the production of therapeutic proteins that has gained more attention due to its increasing demand.https://www.frontiersin.org/article/10.3389/fphar.2018.00630/fullcell line engineeringantibodiesCRISPR-Casgene editingRNAiribozymes |
| spellingShingle | Arun K. Dangi Rajeshwari Sinha Shailja Dwivedi Sanjeev K. Gupta Pratyoosh Shukla Cell Line Techniques and Gene Editing Tools for Antibody Production: A Review Frontiers in Pharmacology cell line engineering antibodies CRISPR-Cas gene editing RNAi ribozymes |
| title | Cell Line Techniques and Gene Editing Tools for Antibody Production: A Review |
| title_full | Cell Line Techniques and Gene Editing Tools for Antibody Production: A Review |
| title_fullStr | Cell Line Techniques and Gene Editing Tools for Antibody Production: A Review |
| title_full_unstemmed | Cell Line Techniques and Gene Editing Tools for Antibody Production: A Review |
| title_short | Cell Line Techniques and Gene Editing Tools for Antibody Production: A Review |
| title_sort | cell line techniques and gene editing tools for antibody production a review |
| topic | cell line engineering antibodies CRISPR-Cas gene editing RNAi ribozymes |
| url | https://www.frontiersin.org/article/10.3389/fphar.2018.00630/full |
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