The TNF-alpha-238 polymorphism and cancer risk: a meta-analysis.
BACKGROUND AND OBJECTIVES: Tumor necrosis factor-α (TNF-α) plays a very important role in the development and progress of cancer. Some TNF-α polymorphisms have been confirmed to increase cancer risks; however, the association between TNF-α-238 polymorphism and cancers remains controversial and ambig...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2011-01-01
|
| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3139602?pdf=render |
| _version_ | 1818842927517925376 |
|---|---|
| author | Ping Zhou Guo-Qiang Lv Jian-Zhong Wang Cheng-Wan Li Liang-Feng Du Chun Zhang Jian-Ping Li |
| author_facet | Ping Zhou Guo-Qiang Lv Jian-Zhong Wang Cheng-Wan Li Liang-Feng Du Chun Zhang Jian-Ping Li |
| author_sort | Ping Zhou |
| collection | DOAJ |
| description | BACKGROUND AND OBJECTIVES: Tumor necrosis factor-α (TNF-α) plays a very important role in the development and progress of cancer. Some TNF-α polymorphisms have been confirmed to increase cancer risks; however, the association between TNF-α-238 polymorphism and cancers remains controversial and ambiguous. The aim of this study is to explore a more precise estimation of its relationship with cancer using meta-analysis. METHODS: Electronic searches of several databases were conducted for all publications on the association between this variant and cancer through March 2011. Odds ratios (OR) with 95% confidence intervals (95% CI) were used to access the strength of this association in the random-effect model. RESULTS: Thirty four studies with 34,679 cancer patients and 41,186 healthy controls were included. This meta-analysis showed no significant association between TNF-α-238 polymorphism and cancers (AA+GA vs GG: OR = 1.09, 95%CI = 0.88-1.34). In Caucasian and Asian subgroups, OR values (95% CI) were 1.14 (0.91-1.43) and 0.97 (0.58-1.61), respectively. In the subgroups of cancer type, no significant association was detected. The sensitivity analysis further strengthened the validity of these negative associations. No publication bias was observed in this study. CONCLUSIONS: No significant association was found between the TNF-α-238 polymorphism and the risk for cancer. |
| first_indexed | 2024-12-19T04:49:45Z |
| format | Article |
| id | doaj.art-a50a36e5637045c08012153c6a887341 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-19T04:49:45Z |
| publishDate | 2011-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-a50a36e5637045c08012153c6a8873412022-12-21T20:35:24ZengPublic Library of Science (PLoS)PLoS ONE1932-62032011-01-0167e2209210.1371/journal.pone.0022092The TNF-alpha-238 polymorphism and cancer risk: a meta-analysis.Ping ZhouGuo-Qiang LvJian-Zhong WangCheng-Wan LiLiang-Feng DuChun ZhangJian-Ping LiBACKGROUND AND OBJECTIVES: Tumor necrosis factor-α (TNF-α) plays a very important role in the development and progress of cancer. Some TNF-α polymorphisms have been confirmed to increase cancer risks; however, the association between TNF-α-238 polymorphism and cancers remains controversial and ambiguous. The aim of this study is to explore a more precise estimation of its relationship with cancer using meta-analysis. METHODS: Electronic searches of several databases were conducted for all publications on the association between this variant and cancer through March 2011. Odds ratios (OR) with 95% confidence intervals (95% CI) were used to access the strength of this association in the random-effect model. RESULTS: Thirty four studies with 34,679 cancer patients and 41,186 healthy controls were included. This meta-analysis showed no significant association between TNF-α-238 polymorphism and cancers (AA+GA vs GG: OR = 1.09, 95%CI = 0.88-1.34). In Caucasian and Asian subgroups, OR values (95% CI) were 1.14 (0.91-1.43) and 0.97 (0.58-1.61), respectively. In the subgroups of cancer type, no significant association was detected. The sensitivity analysis further strengthened the validity of these negative associations. No publication bias was observed in this study. CONCLUSIONS: No significant association was found between the TNF-α-238 polymorphism and the risk for cancer.http://europepmc.org/articles/PMC3139602?pdf=render |
| spellingShingle | Ping Zhou Guo-Qiang Lv Jian-Zhong Wang Cheng-Wan Li Liang-Feng Du Chun Zhang Jian-Ping Li The TNF-alpha-238 polymorphism and cancer risk: a meta-analysis. PLoS ONE |
| title | The TNF-alpha-238 polymorphism and cancer risk: a meta-analysis. |
| title_full | The TNF-alpha-238 polymorphism and cancer risk: a meta-analysis. |
| title_fullStr | The TNF-alpha-238 polymorphism and cancer risk: a meta-analysis. |
| title_full_unstemmed | The TNF-alpha-238 polymorphism and cancer risk: a meta-analysis. |
| title_short | The TNF-alpha-238 polymorphism and cancer risk: a meta-analysis. |
| title_sort | tnf alpha 238 polymorphism and cancer risk a meta analysis |
| url | http://europepmc.org/articles/PMC3139602?pdf=render |
| work_keys_str_mv | AT pingzhou thetnfalpha238polymorphismandcancerriskametaanalysis AT guoqianglv thetnfalpha238polymorphismandcancerriskametaanalysis AT jianzhongwang thetnfalpha238polymorphismandcancerriskametaanalysis AT chengwanli thetnfalpha238polymorphismandcancerriskametaanalysis AT liangfengdu thetnfalpha238polymorphismandcancerriskametaanalysis AT chunzhang thetnfalpha238polymorphismandcancerriskametaanalysis AT jianpingli thetnfalpha238polymorphismandcancerriskametaanalysis AT pingzhou tnfalpha238polymorphismandcancerriskametaanalysis AT guoqianglv tnfalpha238polymorphismandcancerriskametaanalysis AT jianzhongwang tnfalpha238polymorphismandcancerriskametaanalysis AT chengwanli tnfalpha238polymorphismandcancerriskametaanalysis AT liangfengdu tnfalpha238polymorphismandcancerriskametaanalysis AT chunzhang tnfalpha238polymorphismandcancerriskametaanalysis AT jianpingli tnfalpha238polymorphismandcancerriskametaanalysis |