Fibroblast-like synovial cell production of extra domain A fibronectin associates with inflammation in osteoarthritis

Fibroblast-like synovial cell production of extra domain A fibronectin associates with inflammation in osteoarthritis

Abstract Background The pathophysiology of osteoarthritis (OA) involves wear and tear, and a state of low-grade inflammation. Tissue repair responses include transforming growth factor beta (TGFβ)-induced myofibroblast production of extracellular matrix. Fibronectins are an essential part of the ext...

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Bibliographic Details
Main Authors: Tue W. Kragstrup, Dong H. Sohn, Christin M. Lepus, Kazuhiro Onuma, Qian Wang, William H. Robinson, Jeremy Sokolove
Format: Article
Language:English
Published: BMC 2019-12-01
Series:BMC Rheumatology
Subjects:
Osteoarthritis
Fibronectin
Myofibroblast
Inflammation
Arthritis
Synovitis
Online Access:https://doi.org/10.1186/s41927-019-0093-4

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