Novel Suicide Ligands of Tubulin Arrest Cancer Cells in S-Phase

It is presently accepted that the mechanism of action for all anti-tumor tubulin ligands involves the perturbation of microtubule dynamics during the G2/M phase of cell division and subsequent entry into apoptosis 1]. In this report, we challenge the established dogma by describing a unique mechanis...

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Hlavní autoři: Ashley Davis, Jian-Dong Jiang, Kim M. Middleton, Yue Wang, Imre Weisz, Yi-He Ling, J. George Bekesi
Médium: Článek
Jazyk:English
Vydáno: Elsevier 1999-12-01
Edice:Neoplasia: An International Journal for Oncology Research
Témata:
On-line přístup:http://www.sciencedirect.com/science/article/pii/S1476558699800037