Novel Suicide Ligands of Tubulin Arrest Cancer Cells in S-Phase

It is presently accepted that the mechanism of action for all anti-tumor tubulin ligands involves the perturbation of microtubule dynamics during the G2/M phase of cell division and subsequent entry into apoptosis 1]. In this report, we challenge the established dogma by describing a unique mechanis...

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Detalles Bibliográficos
Autores principales: Ashley Davis, Jian-Dong Jiang, Kim M. Middleton, Yue Wang, Imre Weisz, Yi-He Ling, J. George Bekesi
Formato: Artículo
Lenguaje:English
Publicado: Elsevier 1999-12-01
Colección:Neoplasia: An International Journal for Oncology Research
Materias:
Acceso en línea:http://www.sciencedirect.com/science/article/pii/S1476558699800037