Deletion of a Single LeishIF4E-3 Allele by the CRISPR-Cas9 System Alters Cell Morphology and Infectivity of <italic toggle="yes">Leishmania</italic>

Deletion of a Single LeishIF4E-3 Allele by the CRISPR-Cas9 System Alters Cell Morphology and Infectivity of <italic toggle="yes">Leishmania</italic>

ABSTRACT The genomes of Leishmania and trypanosomes encode six paralogs of the eIF4E cap-binding protein, known in other eukaryotes to anchor the translation initiation complex. In line with the heteroxenous nature of these parasites, the different LeishIF4E paralogs vary in their biophysical featur...

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Bibliographic Details
Main Authors: Rohit Shrivastava, Nitin Tupperwar, Matan Drory-Retwitzer, Michal Shapira
Format: Article
Language:English
Published: American Society for Microbiology 2019-10-01
Series:mSphere
Subjects:
CRISPR
CRISPR-Cas9
LeishIF4E-3
Leishmania
translation
Online Access:https://journals.asm.org/doi/10.1128/mSphere.00450-19

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