Predictive impact of different acute cannabis intoxication effects with regard to abstinence motivation and cessation of use
Abstract Cannabis use is a common risk factor for psychoses. But although prevalence of consumption as well as potency of cannabis increased, the incidence of schizophrenia remained stable. The discontinuation hypothesis suggests that a potential increase of psychoses incidence may be relativized by...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-01-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-27592-6 |
| _version_ | 1797952569644941312 |
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| author | Thomas Schnell Christina-Marie Grömm Nils Klöckner |
| author_facet | Thomas Schnell Christina-Marie Grömm Nils Klöckner |
| author_sort | Thomas Schnell |
| collection | DOAJ |
| description | Abstract Cannabis use is a common risk factor for psychoses. But although prevalence of consumption as well as potency of cannabis increased, the incidence of schizophrenia remained stable. The discontinuation hypothesis suggests that a potential increase of psychoses incidence may be relativized by more frequent cessation of consumption due to higher rates of adverse psychosis-like intoxication effects (PLE), caused by stronger cannabis. A mixed methods online survey was administered to 441 current and past users to analyze the predictive impact of different acute intoxication effects regarding abstinence motivation/cessation of use. Our hypothesis was that PLE would be experienced as the most aversive intoxication effect and therefore have the highest predictive significance. Possible confounds were included (craving, patterns of consumption and sociodemographics). Further analyzes compared past versus current users regarding the quality of intoxication effects, suggesting that past users retrospectively experienced more unpleasant experiences than current users. Free-text data explored subjective reasons for abstinence. We found that paranoid/dysphoric intoxication effects were most predictive for abstinence motivation. Less predictive were psychosis-like intoxication effects such as hallucinations. Group comparisons revealed significant more unpleasurable and less positive intoxication effects in past users compared with current users. Current users with the intention to stop consumption showed significantly more paranoia/dysphoria intoxication compared to users with no intention to stop use. As a conclusion, different intoxication experiences have different effects on abstinence motivation and substance use behavior. They therefore provide a focus that should be increasingly integrated into treatment concepts. |
| first_indexed | 2024-04-10T22:49:37Z |
| format | Article |
| id | doaj.art-a50e1804eee6433eab0f6bbf65524a5f |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-10T22:49:37Z |
| publishDate | 2023-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-a50e1804eee6433eab0f6bbf65524a5f2023-01-15T12:08:26ZengNature PortfolioScientific Reports2045-23222023-01-0113111110.1038/s41598-023-27592-6Predictive impact of different acute cannabis intoxication effects with regard to abstinence motivation and cessation of useThomas Schnell0Christina-Marie Grömm1Nils Klöckner2Medical School Hamburg, University of Applied Sciences and Medical UniversityMedical School Hamburg, University of Applied Sciences and Medical UniversityMedical School Hamburg, University of Applied Sciences and Medical UniversityAbstract Cannabis use is a common risk factor for psychoses. But although prevalence of consumption as well as potency of cannabis increased, the incidence of schizophrenia remained stable. The discontinuation hypothesis suggests that a potential increase of psychoses incidence may be relativized by more frequent cessation of consumption due to higher rates of adverse psychosis-like intoxication effects (PLE), caused by stronger cannabis. A mixed methods online survey was administered to 441 current and past users to analyze the predictive impact of different acute intoxication effects regarding abstinence motivation/cessation of use. Our hypothesis was that PLE would be experienced as the most aversive intoxication effect and therefore have the highest predictive significance. Possible confounds were included (craving, patterns of consumption and sociodemographics). Further analyzes compared past versus current users regarding the quality of intoxication effects, suggesting that past users retrospectively experienced more unpleasant experiences than current users. Free-text data explored subjective reasons for abstinence. We found that paranoid/dysphoric intoxication effects were most predictive for abstinence motivation. Less predictive were psychosis-like intoxication effects such as hallucinations. Group comparisons revealed significant more unpleasurable and less positive intoxication effects in past users compared with current users. Current users with the intention to stop consumption showed significantly more paranoia/dysphoria intoxication compared to users with no intention to stop use. As a conclusion, different intoxication experiences have different effects on abstinence motivation and substance use behavior. They therefore provide a focus that should be increasingly integrated into treatment concepts.https://doi.org/10.1038/s41598-023-27592-6 |
| spellingShingle | Thomas Schnell Christina-Marie Grömm Nils Klöckner Predictive impact of different acute cannabis intoxication effects with regard to abstinence motivation and cessation of use Scientific Reports |
| title | Predictive impact of different acute cannabis intoxication effects with regard to abstinence motivation and cessation of use |
| title_full | Predictive impact of different acute cannabis intoxication effects with regard to abstinence motivation and cessation of use |
| title_fullStr | Predictive impact of different acute cannabis intoxication effects with regard to abstinence motivation and cessation of use |
| title_full_unstemmed | Predictive impact of different acute cannabis intoxication effects with regard to abstinence motivation and cessation of use |
| title_short | Predictive impact of different acute cannabis intoxication effects with regard to abstinence motivation and cessation of use |
| title_sort | predictive impact of different acute cannabis intoxication effects with regard to abstinence motivation and cessation of use |
| url | https://doi.org/10.1038/s41598-023-27592-6 |
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