Cellular Senescence and Periodontitis: Mechanisms and Therapeutics
Periodontitis is a chronic inflammatory disease which increases in prevalence and severity in the older population. Aging is a leading risk factor for periodontitis, which exacerbates alveolar bone loss and results in tooth loss in the elderly. However, the mechanism by which aging affects periodont...
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MDPI AG
2022-09-01
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| Series: | Biology |
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| Online Access: | https://www.mdpi.com/2079-7737/11/10/1419 |
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| author | Sijia Chen Dian Zhou Ousheng Liu Huan Chen Yuehong Wang Yueying Zhou |
| author_facet | Sijia Chen Dian Zhou Ousheng Liu Huan Chen Yuehong Wang Yueying Zhou |
| author_sort | Sijia Chen |
| collection | DOAJ |
| description | Periodontitis is a chronic inflammatory disease which increases in prevalence and severity in the older population. Aging is a leading risk factor for periodontitis, which exacerbates alveolar bone loss and results in tooth loss in the elderly. However, the mechanism by which aging affects periodontitis is not well understood. There is considerable evidence to suggest that targeting cellular senescence could slow down the fundamental aging process, and thus alleviate a series of age-related pathological conditions, likely including alveolar bone loss. Recently, it has been discovered that the senescent cells accumulate in the alveolar bone and promote a senescence-associated secretory phenotype (SASP). Senescent cells interacting with bacteria, together with secreted SASP components altering the local microenvironment and inducing paracrine effects in neighboring cells, exacerbate the chronic inflammation in periodontal tissue and lead to more alveolar bone loss. This review will probe into mechanisms underlying excessive alveolar bone loss in periodontitis with aging and discuss potential therapeutics for the treatment of alveolar bone loss targeting cellular senescence and the SASP. Inspecting the relationship between cellular senescence and periodontitis will lead to new avenues of research in this field and contribute to developing potential translatable clinical interventions to mitigate or even reverse the harmful effects of aging on oral health. |
| first_indexed | 2024-03-09T20:41:01Z |
| format | Article |
| id | doaj.art-a510e80169824ef7a8cbc828c1dd0600 |
| institution | Directory Open Access Journal |
| issn | 2079-7737 |
| language | English |
| last_indexed | 2024-03-09T20:41:01Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biology |
| spelling | doaj.art-a510e80169824ef7a8cbc828c1dd06002023-11-23T22:59:16ZengMDPI AGBiology2079-77372022-09-011110141910.3390/biology11101419Cellular Senescence and Periodontitis: Mechanisms and TherapeuticsSijia Chen0Dian Zhou1Ousheng Liu2Huan Chen3Yuehong Wang4Yueying Zhou5Hunan Key Laboratory of Oral Health Research, Hunan 3D Printing Engineering Research Center of Oral Care, Hunan Clinical Research Center of Oral Major Diseases and Oral Health, Xiangya Stomatological Hospital, Xiangya School of Stomatology, Central South University, Changsha 410013, ChinaHunan Key Laboratory of Oral Health Research, Hunan 3D Printing Engineering Research Center of Oral Care, Hunan Clinical Research Center of Oral Major Diseases and Oral Health, Xiangya Stomatological Hospital, Xiangya School of Stomatology, Central South University, Changsha 410013, ChinaHunan Key Laboratory of Oral Health Research, Hunan 3D Printing Engineering Research Center of Oral Care, Hunan Clinical Research Center of Oral Major Diseases and Oral Health, Xiangya Stomatological Hospital, Xiangya School of Stomatology, Central South University, Changsha 410013, ChinaHunan Key Laboratory of Oral Health Research, Hunan 3D Printing Engineering Research Center of Oral Care, Hunan Clinical Research Center of Oral Major Diseases and Oral Health, Xiangya Stomatological Hospital, Xiangya School of Stomatology, Central South University, Changsha 410013, ChinaHunan Key Laboratory of Oral Health Research, Hunan 3D Printing Engineering Research Center of Oral Care, Hunan Clinical Research Center of Oral Major Diseases and Oral Health, Xiangya Stomatological Hospital, Xiangya School of Stomatology, Central South University, Changsha 410013, ChinaHunan Key Laboratory of Oral Health Research, Hunan 3D Printing Engineering Research Center of Oral Care, Hunan Clinical Research Center of Oral Major Diseases and Oral Health, Xiangya Stomatological Hospital, Xiangya School of Stomatology, Central South University, Changsha 410013, ChinaPeriodontitis is a chronic inflammatory disease which increases in prevalence and severity in the older population. Aging is a leading risk factor for periodontitis, which exacerbates alveolar bone loss and results in tooth loss in the elderly. However, the mechanism by which aging affects periodontitis is not well understood. There is considerable evidence to suggest that targeting cellular senescence could slow down the fundamental aging process, and thus alleviate a series of age-related pathological conditions, likely including alveolar bone loss. Recently, it has been discovered that the senescent cells accumulate in the alveolar bone and promote a senescence-associated secretory phenotype (SASP). Senescent cells interacting with bacteria, together with secreted SASP components altering the local microenvironment and inducing paracrine effects in neighboring cells, exacerbate the chronic inflammation in periodontal tissue and lead to more alveolar bone loss. This review will probe into mechanisms underlying excessive alveolar bone loss in periodontitis with aging and discuss potential therapeutics for the treatment of alveolar bone loss targeting cellular senescence and the SASP. Inspecting the relationship between cellular senescence and periodontitis will lead to new avenues of research in this field and contribute to developing potential translatable clinical interventions to mitigate or even reverse the harmful effects of aging on oral health.https://www.mdpi.com/2079-7737/11/10/1419periodontitisagingcellular senescenceSASP |
| spellingShingle | Sijia Chen Dian Zhou Ousheng Liu Huan Chen Yuehong Wang Yueying Zhou Cellular Senescence and Periodontitis: Mechanisms and Therapeutics Biology periodontitis aging cellular senescence SASP |
| title | Cellular Senescence and Periodontitis: Mechanisms and Therapeutics |
| title_full | Cellular Senescence and Periodontitis: Mechanisms and Therapeutics |
| title_fullStr | Cellular Senescence and Periodontitis: Mechanisms and Therapeutics |
| title_full_unstemmed | Cellular Senescence and Periodontitis: Mechanisms and Therapeutics |
| title_short | Cellular Senescence and Periodontitis: Mechanisms and Therapeutics |
| title_sort | cellular senescence and periodontitis mechanisms and therapeutics |
| topic | periodontitis aging cellular senescence SASP |
| url | https://www.mdpi.com/2079-7737/11/10/1419 |
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