A patient with familial Mediterranean fever mimicking diarrhea-dominant irritable bowel syndrome who successfully responded to treatment with colchicine: a case report
Abstract Background Irritable bowel syndrome is a functional gastrointestinal disease. Visceral hypersensitivity is the most important pathophysiology in irritable bowel syndrome. Currently, diagnosis of irritable bowel syndrome is based on symptoms and exclusion of other organic diseases. Although...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-06-01
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| Series: | Journal of Medical Case Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13256-022-03446-z |
| _version_ | 1811227046009896960 |
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| author | Shima Kumei Masatomo Ishioh Yuki Murakami Katsuyoshi Ando Tsukasa Nozu Toshikatsu Okumura |
| author_facet | Shima Kumei Masatomo Ishioh Yuki Murakami Katsuyoshi Ando Tsukasa Nozu Toshikatsu Okumura |
| author_sort | Shima Kumei |
| collection | DOAJ |
| description | Abstract Background Irritable bowel syndrome is a functional gastrointestinal disease. Visceral hypersensitivity is the most important pathophysiology in irritable bowel syndrome. Currently, diagnosis of irritable bowel syndrome is based on symptoms and exclusion of other organic diseases. Although the diagnosis of irritable bowel syndrome can be made based on the Rome IV criteria, one may speculate that complete exclusion of other organic diseases is not so easy, especially in cases uncontrolled with standard therapies. Case presentation We present herein a case of familial Mediterranean fever in a young Japanese patient who had been suffering from an irritable bowel syndrome-like clinical course. A 25-year-old Japanese male had been diagnosed as having diarrhea-predominant irritable bowel syndrome 5 years earlier. Unfortunately, standard therapies failed to improve irritable bowel syndrome symptoms. After careful medical history-taking, we understood that he had also experienced periodic fever since 10 years ago. Although no mutation was identified in the Mediterranean fever gene, not only periodic fever but abdominal symptoms improved completely after colchicine administration. He was therefore diagnosed as having familial Mediterranean fever and that the abdominal symptoms may be related to the disease. Conclusions Familial Mediterranean fever should be considered as a cause of irritable bowel syndrome-like symptoms. |
| first_indexed | 2024-04-12T09:34:33Z |
| format | Article |
| id | doaj.art-a51199dbd44e4690a87a52a5a494e9fe |
| institution | Directory Open Access Journal |
| issn | 1752-1947 |
| language | English |
| last_indexed | 2024-04-12T09:34:33Z |
| publishDate | 2022-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Medical Case Reports |
| spelling | doaj.art-a51199dbd44e4690a87a52a5a494e9fe2022-12-22T03:38:16ZengBMCJournal of Medical Case Reports1752-19472022-06-011611510.1186/s13256-022-03446-zA patient with familial Mediterranean fever mimicking diarrhea-dominant irritable bowel syndrome who successfully responded to treatment with colchicine: a case reportShima Kumei0Masatomo Ishioh1Yuki Murakami2Katsuyoshi Ando3Tsukasa Nozu4Toshikatsu Okumura5Department of General Medicine, Asahikawa Medical UniversityDivision of Metabolism, Systemic Bioscience, Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical UniversityDivision of Metabolism, Systemic Bioscience, Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical UniversityDivision of Metabolism, Systemic Bioscience, Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical UniversityDepartment of Regional Medicine and Education, Asahikawa Medical UniversityDepartment of General Medicine, Asahikawa Medical UniversityAbstract Background Irritable bowel syndrome is a functional gastrointestinal disease. Visceral hypersensitivity is the most important pathophysiology in irritable bowel syndrome. Currently, diagnosis of irritable bowel syndrome is based on symptoms and exclusion of other organic diseases. Although the diagnosis of irritable bowel syndrome can be made based on the Rome IV criteria, one may speculate that complete exclusion of other organic diseases is not so easy, especially in cases uncontrolled with standard therapies. Case presentation We present herein a case of familial Mediterranean fever in a young Japanese patient who had been suffering from an irritable bowel syndrome-like clinical course. A 25-year-old Japanese male had been diagnosed as having diarrhea-predominant irritable bowel syndrome 5 years earlier. Unfortunately, standard therapies failed to improve irritable bowel syndrome symptoms. After careful medical history-taking, we understood that he had also experienced periodic fever since 10 years ago. Although no mutation was identified in the Mediterranean fever gene, not only periodic fever but abdominal symptoms improved completely after colchicine administration. He was therefore diagnosed as having familial Mediterranean fever and that the abdominal symptoms may be related to the disease. Conclusions Familial Mediterranean fever should be considered as a cause of irritable bowel syndrome-like symptoms.https://doi.org/10.1186/s13256-022-03446-zFamilial Mediterranean feverIrritable bowel syndromeColchicine |
| spellingShingle | Shima Kumei Masatomo Ishioh Yuki Murakami Katsuyoshi Ando Tsukasa Nozu Toshikatsu Okumura A patient with familial Mediterranean fever mimicking diarrhea-dominant irritable bowel syndrome who successfully responded to treatment with colchicine: a case report Journal of Medical Case Reports Familial Mediterranean fever Irritable bowel syndrome Colchicine |
| title | A patient with familial Mediterranean fever mimicking diarrhea-dominant irritable bowel syndrome who successfully responded to treatment with colchicine: a case report |
| title_full | A patient with familial Mediterranean fever mimicking diarrhea-dominant irritable bowel syndrome who successfully responded to treatment with colchicine: a case report |
| title_fullStr | A patient with familial Mediterranean fever mimicking diarrhea-dominant irritable bowel syndrome who successfully responded to treatment with colchicine: a case report |
| title_full_unstemmed | A patient with familial Mediterranean fever mimicking diarrhea-dominant irritable bowel syndrome who successfully responded to treatment with colchicine: a case report |
| title_short | A patient with familial Mediterranean fever mimicking diarrhea-dominant irritable bowel syndrome who successfully responded to treatment with colchicine: a case report |
| title_sort | patient with familial mediterranean fever mimicking diarrhea dominant irritable bowel syndrome who successfully responded to treatment with colchicine a case report |
| topic | Familial Mediterranean fever Irritable bowel syndrome Colchicine |
| url | https://doi.org/10.1186/s13256-022-03446-z |
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