Drug Exposure During Pregnancy: A Case-Control Study from a Primary Care Database
Objective: Drug exposure during pregnancy is frequent, even more during first trimester as pregnant women might not be aware of their condition. We used available electronic health records (EHRs) to describe the use of medications during the first trimester in pregnant women and to compare drug expo...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Mary Ann Liebert
2024-01-01
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| Series: | Women's Health Reports |
| Subjects: | |
| Online Access: | https://www.liebertpub.com/doi/full/10.1089/WHR.2023.0123 |
| _version_ | 1797345728376340480 |
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| author | Ainhoa Gomez-Lumbreras Marta Leston Vazquez Carles Vilaplana-Carnerero Oriol Prat-Vallverdu Cristina Vedia Rosa Morros Maria Giner-Soriano |
| author_facet | Ainhoa Gomez-Lumbreras Marta Leston Vazquez Carles Vilaplana-Carnerero Oriol Prat-Vallverdu Cristina Vedia Rosa Morros Maria Giner-Soriano |
| author_sort | Ainhoa Gomez-Lumbreras |
| collection | DOAJ |
| description | Objective: Drug exposure during pregnancy is frequent, even more during first trimester as pregnant women might not be aware of their condition. We used available electronic health records (EHRs) to describe the use of medications during the first trimester in pregnant women and to compare drug exposure between those women who had an abortion (either elective or spontaneous) compared to those who had live births.
Materials and Methods: Case-control study of abortions, either elective or spontaneous (cases), and live birth pregnancies (controls) in Sistema d'Informaci? per al Desenvolupament de la Investigaci? en Atenci? Prim?ria (Catalan Primary Health electronic health records) from 2012 to 2020. Exposure to drugs during first trimester of pregnancy was considered to estimate the association with abortion by conditional logistic regression and adjusted by health conditions and other drugs exposure.
Results: Sixty thousand three hundred fifty episodes of abortions were matched to 118,085 live birth pregnancy episodes. Cases had higher rates of alcohol intake (9.9% vs. 7.2%, p?<?0.001), smoking (4.5% vs. 3.6%, p?<?0.001), and previous abortions (9.9% vs. 7.8%, p?<?0.001). Anxiety (30.3% and 25.1%, p?<?0.001), respiratory diseases (10.6% and 9.2%, p?<?0.001), and migraine (8.2% and 7.3%, p?<?0.001), for cases and controls, respectively, were the most frequent baseline conditions. Cases had lower rate of drug exposure, 40,148 (66.5%) versus 80,449 (68.1%), p?<?0.001. Association with abortion was found for systemic antihistamines (adjusted odds ratio [ORadj] 1.23, 95% confidence interval [CI] 1.19?1.27), antidepressants (ORadj 1.11, 95% CI 1.06?1.17), anxiolytics (ORadj 1.31, 95% CI 1.26?1.73), and nonsteroidal anti-inflammatory drugs (ORadj 1. 63, 95% CI 1.59?1.67).
Conclusions: These high rates of drug exposures during the first trimester of pregnancy highlights the relevance of informed prescription to women with childbearing potential. |
| first_indexed | 2024-03-08T11:22:43Z |
| format | Article |
| id | doaj.art-a511ab1f905343458de3c42dccc2f24d |
| institution | Directory Open Access Journal |
| issn | 2688-4844 |
| language | English |
| last_indexed | 2024-03-08T11:22:43Z |
| publishDate | 2024-01-01 |
| publisher | Mary Ann Liebert |
| record_format | Article |
| series | Women's Health Reports |
| spelling | doaj.art-a511ab1f905343458de3c42dccc2f24d2024-01-26T06:07:30ZengMary Ann LiebertWomen's Health Reports2688-48442024-01-0151132110.1089/WHR.2023.0123Drug Exposure During Pregnancy: A Case-Control Study from a Primary Care DatabaseAinhoa Gomez-LumbrerasMarta Leston VazquezCarles Vilaplana-CarnereroOriol Prat-VallverduCristina VediaRosa MorrosMaria Giner-SorianoObjective: Drug exposure during pregnancy is frequent, even more during first trimester as pregnant women might not be aware of their condition. We used available electronic health records (EHRs) to describe the use of medications during the first trimester in pregnant women and to compare drug exposure between those women who had an abortion (either elective or spontaneous) compared to those who had live births. Materials and Methods: Case-control study of abortions, either elective or spontaneous (cases), and live birth pregnancies (controls) in Sistema d'Informaci? per al Desenvolupament de la Investigaci? en Atenci? Prim?ria (Catalan Primary Health electronic health records) from 2012 to 2020. Exposure to drugs during first trimester of pregnancy was considered to estimate the association with abortion by conditional logistic regression and adjusted by health conditions and other drugs exposure. Results: Sixty thousand three hundred fifty episodes of abortions were matched to 118,085 live birth pregnancy episodes. Cases had higher rates of alcohol intake (9.9% vs. 7.2%, p?<?0.001), smoking (4.5% vs. 3.6%, p?<?0.001), and previous abortions (9.9% vs. 7.8%, p?<?0.001). Anxiety (30.3% and 25.1%, p?<?0.001), respiratory diseases (10.6% and 9.2%, p?<?0.001), and migraine (8.2% and 7.3%, p?<?0.001), for cases and controls, respectively, were the most frequent baseline conditions. Cases had lower rate of drug exposure, 40,148 (66.5%) versus 80,449 (68.1%), p?<?0.001. Association with abortion was found for systemic antihistamines (adjusted odds ratio [ORadj] 1.23, 95% confidence interval [CI] 1.19?1.27), antidepressants (ORadj 1.11, 95% CI 1.06?1.17), anxiolytics (ORadj 1.31, 95% CI 1.26?1.73), and nonsteroidal anti-inflammatory drugs (ORadj 1. 63, 95% CI 1.59?1.67). Conclusions: These high rates of drug exposures during the first trimester of pregnancy highlights the relevance of informed prescription to women with childbearing potential.https://www.liebertpub.com/doi/full/10.1089/WHR.2023.0123abortion, inducedabortion, spontaneouslabor, obstetriclive birthabnormalities, drug-inducedmaternal-fetal exchange |
| spellingShingle | Ainhoa Gomez-Lumbreras Marta Leston Vazquez Carles Vilaplana-Carnerero Oriol Prat-Vallverdu Cristina Vedia Rosa Morros Maria Giner-Soriano Drug Exposure During Pregnancy: A Case-Control Study from a Primary Care Database Women's Health Reports abortion, induced abortion, spontaneous labor, obstetric live birth abnormalities, drug-induced maternal-fetal exchange |
| title | Drug Exposure During Pregnancy: A Case-Control Study from a Primary Care Database |
| title_full | Drug Exposure During Pregnancy: A Case-Control Study from a Primary Care Database |
| title_fullStr | Drug Exposure During Pregnancy: A Case-Control Study from a Primary Care Database |
| title_full_unstemmed | Drug Exposure During Pregnancy: A Case-Control Study from a Primary Care Database |
| title_short | Drug Exposure During Pregnancy: A Case-Control Study from a Primary Care Database |
| title_sort | drug exposure during pregnancy a case control study from a primary care database |
| topic | abortion, induced abortion, spontaneous labor, obstetric live birth abnormalities, drug-induced maternal-fetal exchange |
| url | https://www.liebertpub.com/doi/full/10.1089/WHR.2023.0123 |
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