Plasma CXCL8 and MCP-1 as surrogate plasma biomarkers of latent tuberculosis infection among household contacts-A cross-sectional study.
Early detection of latent tuberculosis infection (LTBI) is critical to TB elimination in the current WHO vision of End Tuberculosis Strategy. The study investigates whether detecting plasma cytokines could aid in diagnosing LTBI across household contacts (HHCs) positive for IGRA, HHCs negative for I...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2023-01-01
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| Series: | PLOS Global Public Health |
| Online Access: | https://journals.plos.org/globalpublichealth/article/file?id=10.1371/journal.pgph.0002327&type=printable |
| _version_ | 1797315865222316032 |
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| author | Sivaprakasam T Selvavinayagam Bijulal Aswathy Yean K Yong Asha Frederick Lakshmi Murali Vasudevan Kalaivani Sree J Karishma Manivannan Rajeshkumar Adukkadukkam Anusree Meganathan Kannan Natarajan Gopalan Ramachandran Vignesh Amudhan Murugesan Hong Yien Tan Ying Zhang Samudi Chandramathi Munusamy Ponnan Sivasankaran Pachamuthu Balakrishnan Sakthivel Govindaraj Siddappa N Byrareddy Vijayakumar Velu Marie Larsson Esaki M Shankar Sivadoss Raju |
| author_facet | Sivaprakasam T Selvavinayagam Bijulal Aswathy Yean K Yong Asha Frederick Lakshmi Murali Vasudevan Kalaivani Sree J Karishma Manivannan Rajeshkumar Adukkadukkam Anusree Meganathan Kannan Natarajan Gopalan Ramachandran Vignesh Amudhan Murugesan Hong Yien Tan Ying Zhang Samudi Chandramathi Munusamy Ponnan Sivasankaran Pachamuthu Balakrishnan Sakthivel Govindaraj Siddappa N Byrareddy Vijayakumar Velu Marie Larsson Esaki M Shankar Sivadoss Raju |
| author_sort | Sivaprakasam T Selvavinayagam |
| collection | DOAJ |
| description | Early detection of latent tuberculosis infection (LTBI) is critical to TB elimination in the current WHO vision of End Tuberculosis Strategy. The study investigates whether detecting plasma cytokines could aid in diagnosing LTBI across household contacts (HHCs) positive for IGRA, HHCs negative for IGRA, and healthy controls. The plasma cytokines were measured using a commercial Bio-Plex Pro Human Cytokine 17-plex assay. Increased plasma CXCL8 and decreased MCP-1, TNF-α, and IFN-γ were associated with LTBI. Regression analysis showed that a combination of CXCL8 and MCP-1 increased the risk of LTBI among HHCs to 14-fold. Our study suggests that CXCL-8 and MCP-1 could serve as the surrogate biomarkers of LTBI, particularly in resource-limited settings. Further laboratory investigations are warranted before extrapolating CXCL8 and MCP-1 for their usefulness as surrogate biomarkers of LTBI in resource-limited settings. |
| first_indexed | 2024-03-08T03:10:01Z |
| format | Article |
| id | doaj.art-a51334833c1f4179908ad29c718e7171 |
| institution | Directory Open Access Journal |
| issn | 2767-3375 |
| language | English |
| last_indexed | 2024-03-08T03:10:01Z |
| publishDate | 2023-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLOS Global Public Health |
| spelling | doaj.art-a51334833c1f4179908ad29c718e71712024-02-13T06:00:18ZengPublic Library of Science (PLoS)PLOS Global Public Health2767-33752023-01-01311e000232710.1371/journal.pgph.0002327Plasma CXCL8 and MCP-1 as surrogate plasma biomarkers of latent tuberculosis infection among household contacts-A cross-sectional study.Sivaprakasam T SelvavinayagamBijulal AswathyYean K YongAsha FrederickLakshmi MuraliVasudevan KalaivaniSree J KarishmaManivannan RajeshkumarAdukkadukkam AnusreeMeganathan KannanNatarajan GopalanRamachandran VigneshAmudhan MurugesanHong Yien TanYing ZhangSamudi ChandramathiMunusamy Ponnan SivasankaranPachamuthu BalakrishnanSakthivel GovindarajSiddappa N ByrareddyVijayakumar VeluMarie LarssonEsaki M ShankarSivadoss RajuEarly detection of latent tuberculosis infection (LTBI) is critical to TB elimination in the current WHO vision of End Tuberculosis Strategy. The study investigates whether detecting plasma cytokines could aid in diagnosing LTBI across household contacts (HHCs) positive for IGRA, HHCs negative for IGRA, and healthy controls. The plasma cytokines were measured using a commercial Bio-Plex Pro Human Cytokine 17-plex assay. Increased plasma CXCL8 and decreased MCP-1, TNF-α, and IFN-γ were associated with LTBI. Regression analysis showed that a combination of CXCL8 and MCP-1 increased the risk of LTBI among HHCs to 14-fold. Our study suggests that CXCL-8 and MCP-1 could serve as the surrogate biomarkers of LTBI, particularly in resource-limited settings. Further laboratory investigations are warranted before extrapolating CXCL8 and MCP-1 for their usefulness as surrogate biomarkers of LTBI in resource-limited settings.https://journals.plos.org/globalpublichealth/article/file?id=10.1371/journal.pgph.0002327&type=printable |
| spellingShingle | Sivaprakasam T Selvavinayagam Bijulal Aswathy Yean K Yong Asha Frederick Lakshmi Murali Vasudevan Kalaivani Sree J Karishma Manivannan Rajeshkumar Adukkadukkam Anusree Meganathan Kannan Natarajan Gopalan Ramachandran Vignesh Amudhan Murugesan Hong Yien Tan Ying Zhang Samudi Chandramathi Munusamy Ponnan Sivasankaran Pachamuthu Balakrishnan Sakthivel Govindaraj Siddappa N Byrareddy Vijayakumar Velu Marie Larsson Esaki M Shankar Sivadoss Raju Plasma CXCL8 and MCP-1 as surrogate plasma biomarkers of latent tuberculosis infection among household contacts-A cross-sectional study. PLOS Global Public Health |
| title | Plasma CXCL8 and MCP-1 as surrogate plasma biomarkers of latent tuberculosis infection among household contacts-A cross-sectional study. |
| title_full | Plasma CXCL8 and MCP-1 as surrogate plasma biomarkers of latent tuberculosis infection among household contacts-A cross-sectional study. |
| title_fullStr | Plasma CXCL8 and MCP-1 as surrogate plasma biomarkers of latent tuberculosis infection among household contacts-A cross-sectional study. |
| title_full_unstemmed | Plasma CXCL8 and MCP-1 as surrogate plasma biomarkers of latent tuberculosis infection among household contacts-A cross-sectional study. |
| title_short | Plasma CXCL8 and MCP-1 as surrogate plasma biomarkers of latent tuberculosis infection among household contacts-A cross-sectional study. |
| title_sort | plasma cxcl8 and mcp 1 as surrogate plasma biomarkers of latent tuberculosis infection among household contacts a cross sectional study |
| url | https://journals.plos.org/globalpublichealth/article/file?id=10.1371/journal.pgph.0002327&type=printable |
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