Alzheimer's disease and blood-based biomarkers – potential contexts of use
Martina Zvěřová1,2 1Department of Psychiatry, General University Hospital in Prague, Prague, Czech Republic; 2First Faculty of Medicine, Charles University in Prague, Prague, Czech Republic Abstract: Alzheimer’s disease (AD) is an irreversible, incurable, progressive neurodege...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2018-07-01
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| Series: | Neuropsychiatric Disease and Treatment |
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| Online Access: | https://www.dovepress.com/alzheimers-disease-and-blood-based-biomarkers-potential-contexts-of-us-peer-reviewed-article-NDT |
| _version_ | 1818695486849155072 |
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| author | Zvěřová M |
| author_facet | Zvěřová M |
| author_sort | Zvěřová M |
| collection | DOAJ |
| description | Martina Zvěřová1,2 1Department of Psychiatry, General University Hospital in Prague, Prague, Czech Republic; 2First Faculty of Medicine, Charles University in Prague, Prague, Czech Republic Abstract: Alzheimer’s disease (AD) is an irreversible, incurable, progressive neurodegenerative illness, where dementia symptoms gradually worsen over a number of years. The research of validated biomarkers for AD is essential to improve diagnosis and accelerate the development of new therapies. Biochemical markers including neuroimaging could facilitate diagnosis, predict AD progression from a pre-AD state of mild cognitive impairment, and be used to detect the efficacies of disease-modifying therapies. Established biomarkers of AD from cerebrospinal fluid and neuroimaging are highly accurate, but barriers to clinical implementation exist. The focus on blood-based AD biomarkers has grown exponentially during the past few decades. An ideal diagnostic test for AD should be noninvasive and easily applicable. Clinical cost-effectiveness also needs to be established. Keywords: biomarker, Alzheimer’s disease, neurodegeneration, cerebrospinal fluid, beta amyloid, tau protein |
| first_indexed | 2024-12-17T13:46:15Z |
| format | Article |
| id | doaj.art-a514407a084f4d9b82b3e2f59a195e91 |
| institution | Directory Open Access Journal |
| issn | 1178-2021 |
| language | English |
| last_indexed | 2024-12-17T13:46:15Z |
| publishDate | 2018-07-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Neuropsychiatric Disease and Treatment |
| spelling | doaj.art-a514407a084f4d9b82b3e2f59a195e912022-12-21T21:46:09ZengDove Medical PressNeuropsychiatric Disease and Treatment1178-20212018-07-01Volume 141877188239439Alzheimer's disease and blood-based biomarkers – potential contexts of useZvěřová MMartina Zvěřová1,2 1Department of Psychiatry, General University Hospital in Prague, Prague, Czech Republic; 2First Faculty of Medicine, Charles University in Prague, Prague, Czech Republic Abstract: Alzheimer’s disease (AD) is an irreversible, incurable, progressive neurodegenerative illness, where dementia symptoms gradually worsen over a number of years. The research of validated biomarkers for AD is essential to improve diagnosis and accelerate the development of new therapies. Biochemical markers including neuroimaging could facilitate diagnosis, predict AD progression from a pre-AD state of mild cognitive impairment, and be used to detect the efficacies of disease-modifying therapies. Established biomarkers of AD from cerebrospinal fluid and neuroimaging are highly accurate, but barriers to clinical implementation exist. The focus on blood-based AD biomarkers has grown exponentially during the past few decades. An ideal diagnostic test for AD should be noninvasive and easily applicable. Clinical cost-effectiveness also needs to be established. Keywords: biomarker, Alzheimer’s disease, neurodegeneration, cerebrospinal fluid, beta amyloid, tau proteinhttps://www.dovepress.com/alzheimers-disease-and-blood-based-biomarkers-potential-contexts-of-us-peer-reviewed-article-NDTbiomarkerAlzheimer's diseaseneurodegenerationcerebrospinal fluidbeta amyloidtau protein |
| spellingShingle | Zvěřová M Alzheimer's disease and blood-based biomarkers – potential contexts of use Neuropsychiatric Disease and Treatment biomarker Alzheimer's disease neurodegeneration cerebrospinal fluid beta amyloid tau protein |
| title | Alzheimer's disease and blood-based biomarkers – potential contexts of use |
| title_full | Alzheimer's disease and blood-based biomarkers – potential contexts of use |
| title_fullStr | Alzheimer's disease and blood-based biomarkers – potential contexts of use |
| title_full_unstemmed | Alzheimer's disease and blood-based biomarkers – potential contexts of use |
| title_short | Alzheimer's disease and blood-based biomarkers – potential contexts of use |
| title_sort | alzheimer 39 s disease and blood based biomarkers ndash potential contexts of use |
| topic | biomarker Alzheimer's disease neurodegeneration cerebrospinal fluid beta amyloid tau protein |
| url | https://www.dovepress.com/alzheimers-disease-and-blood-based-biomarkers-potential-contexts-of-us-peer-reviewed-article-NDT |
| work_keys_str_mv | AT zverovam alzheimer39sdiseaseandbloodbasedbiomarkersndashpotentialcontextsofuse |