The partial virological response to Tenofovir monotherapy in naïve patients with chronic hepatitis B
Abstract We report two treatment-naïve cases, a 26-year-old female patient and a 59-year-old male patient who were followed up for chronic hepatitis B (CHB) at the Department of Infectious Diseases and Clinical Microbiology. A partial response subsequent to 12 months of Tenofovir Disoproksil (TD...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Pakistan Medical Association
2020-10-01
|
| Series: | Journal of the Pakistan Medical Association |
| Online Access: | https://www.ojs.jpma.org.pk/index.php/public_html/article/view/1527 |
| _version_ | 1797820532884766720 |
|---|---|
| author | Habip Gedik Muge Sonmezisik |
| author_facet | Habip Gedik Muge Sonmezisik |
| author_sort | Habip Gedik |
| collection | DOAJ |
| description |
Abstract
We report two treatment-naïve cases, a 26-year-old female patient and a 59-year-old male patient who were followed up for chronic hepatitis B (CHB) at the Department of Infectious Diseases and Clinical Microbiology. A partial response subsequent to 12 months of Tenofovir Disoproksil (TDF) monotherapy presumably due to an antiviral-drug resistance was noted. A sustained viral response with TDF (245 mg) or Tenofovir Alafenamide (TAF, 25 mg) + Entecavir (ETV, 1 mg) combination therapy was observed after failure with TDF monotherapy. A combination therapy with TDF (245 mg) or TAF (25 mg) +ETV (1 mg) is efficacious in naïve patients with a partial response to TDF monotherapy.
Keywords: Chronic hepatitis B, Tenofovir, partial response, Entecavir, combination therapy
|
| first_indexed | 2024-03-13T09:40:43Z |
| format | Article |
| id | doaj.art-a5147359045a4ee2993563f2b8d20cc4 |
| institution | Directory Open Access Journal |
| issn | 0030-9982 |
| language | English |
| last_indexed | 2024-03-13T09:40:43Z |
| publishDate | 2020-10-01 |
| publisher | Pakistan Medical Association |
| record_format | Article |
| series | Journal of the Pakistan Medical Association |
| spelling | doaj.art-a5147359045a4ee2993563f2b8d20cc42023-05-25T04:25:36ZengPakistan Medical AssociationJournal of the Pakistan Medical Association0030-99822020-10-0110.47391/JPMA.1135The partial virological response to Tenofovir monotherapy in naïve patients with chronic hepatitis BHabip Gedik0Muge Sonmezisik1Department of Infectious Disease and Clinical Microbiology, University of Health Sciences and Ministry of Health, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, Istanbul, TurkeyDepartment of Infectious Disease and Clinical Microbiology, University of Health Sciences and Ministry of Health, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, Istanbul, Turkey Abstract We report two treatment-naïve cases, a 26-year-old female patient and a 59-year-old male patient who were followed up for chronic hepatitis B (CHB) at the Department of Infectious Diseases and Clinical Microbiology. A partial response subsequent to 12 months of Tenofovir Disoproksil (TDF) monotherapy presumably due to an antiviral-drug resistance was noted. A sustained viral response with TDF (245 mg) or Tenofovir Alafenamide (TAF, 25 mg) + Entecavir (ETV, 1 mg) combination therapy was observed after failure with TDF monotherapy. A combination therapy with TDF (245 mg) or TAF (25 mg) +ETV (1 mg) is efficacious in naïve patients with a partial response to TDF monotherapy. Keywords: Chronic hepatitis B, Tenofovir, partial response, Entecavir, combination therapy https://www.ojs.jpma.org.pk/index.php/public_html/article/view/1527 |
| spellingShingle | Habip Gedik Muge Sonmezisik The partial virological response to Tenofovir monotherapy in naïve patients with chronic hepatitis B Journal of the Pakistan Medical Association |
| title | The partial virological response to Tenofovir monotherapy in naïve patients with chronic hepatitis B |
| title_full | The partial virological response to Tenofovir monotherapy in naïve patients with chronic hepatitis B |
| title_fullStr | The partial virological response to Tenofovir monotherapy in naïve patients with chronic hepatitis B |
| title_full_unstemmed | The partial virological response to Tenofovir monotherapy in naïve patients with chronic hepatitis B |
| title_short | The partial virological response to Tenofovir monotherapy in naïve patients with chronic hepatitis B |
| title_sort | partial virological response to tenofovir monotherapy in naive patients with chronic hepatitis b |
| url | https://www.ojs.jpma.org.pk/index.php/public_html/article/view/1527 |
| work_keys_str_mv | AT habipgedik thepartialvirologicalresponsetotenofovirmonotherapyinnaivepatientswithchronichepatitisb AT mugesonmezisik thepartialvirologicalresponsetotenofovirmonotherapyinnaivepatientswithchronichepatitisb AT habipgedik partialvirologicalresponsetotenofovirmonotherapyinnaivepatientswithchronichepatitisb AT mugesonmezisik partialvirologicalresponsetotenofovirmonotherapyinnaivepatientswithchronichepatitisb |