The utility of glomerular C4d immunostaining in renal biopsies in patients with immunoglobulin A nephropathy. A clinicopathological study
The course of IgA nephropathy (IgAN) is highly variable and ranges from a totally benign condition to end-stage renal disease in approximately one third of cases. The identification of new prognostic markers could provide insights into the pathogenesis of IgAN and unveil new therapeutic avenues. Glo...
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| Format: | Article |
| Language: | English |
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Termedia Publishing House
2017-09-01
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| Series: | Polish Journal of Pathology |
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| Online Access: | https://www.termedia.pl/The-utility-of-glomerular-C4d-immunostaining-in-renal-biopsies-in-patients-with-immunoglobulin-A-nephropathy-A-clinicopathological-study,55,30490,1,1.html |
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| author | Małgorzata Wągrowska-Danilewicz Marian Danilewicz |
| author_facet | Małgorzata Wągrowska-Danilewicz Marian Danilewicz |
| author_sort | Małgorzata Wągrowska-Danilewicz |
| collection | DOAJ |
| description | The course of IgA nephropathy (IgAN) is highly variable and ranges from a totally benign condition to end-stage renal disease in approximately one third of cases. The identification of new prognostic markers could provide insights into the pathogenesis of IgAN and unveil new therapeutic avenues. Glomerular deposition of C4d is a marker of activation of the lectin pathway of complement. It is thought that activation of the lectin pathway in IgAN is associated with more severe renal damage, and more severe histological findings.
In view of the above, the aim of the present study was to compare the clinical presentation, laboratory data, and histological lesions in the renal biopsy in IgAN patients with positive and negative staining for mesangial C4d depositions.
Our study revealed that hypertension, severe proteinuria, a high level of serum creatinine, low eGFR at the time of presentation, as well as tubular atrophy/interstitial fibrosis > 50%, and endocapillary proliferation were significantly more frequent in the C4d (+) group than in the C4d (–) group. Based on our research, we can assume that mesangial immunoexpression of C4d seems to be a useful prognostic factor in IgAN. |
| first_indexed | 2024-12-13T20:58:34Z |
| format | Article |
| id | doaj.art-a51561360d954a9aa099a764d341e7f9 |
| institution | Directory Open Access Journal |
| issn | 1233-9687 2084-9869 |
| language | English |
| last_indexed | 2024-12-13T20:58:34Z |
| publishDate | 2017-09-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Polish Journal of Pathology |
| spelling | doaj.art-a51561360d954a9aa099a764d341e7f92022-12-21T23:31:40ZengTermedia Publishing HousePolish Journal of Pathology1233-96872084-98692017-09-0168214815210.5114/pjp.2017.6969130490The utility of glomerular C4d immunostaining in renal biopsies in patients with immunoglobulin A nephropathy. A clinicopathological studyMałgorzata Wągrowska-DanilewiczMarian DanilewiczThe course of IgA nephropathy (IgAN) is highly variable and ranges from a totally benign condition to end-stage renal disease in approximately one third of cases. The identification of new prognostic markers could provide insights into the pathogenesis of IgAN and unveil new therapeutic avenues. Glomerular deposition of C4d is a marker of activation of the lectin pathway of complement. It is thought that activation of the lectin pathway in IgAN is associated with more severe renal damage, and more severe histological findings. In view of the above, the aim of the present study was to compare the clinical presentation, laboratory data, and histological lesions in the renal biopsy in IgAN patients with positive and negative staining for mesangial C4d depositions. Our study revealed that hypertension, severe proteinuria, a high level of serum creatinine, low eGFR at the time of presentation, as well as tubular atrophy/interstitial fibrosis > 50%, and endocapillary proliferation were significantly more frequent in the C4d (+) group than in the C4d (–) group. Based on our research, we can assume that mesangial immunoexpression of C4d seems to be a useful prognostic factor in IgAN.https://www.termedia.pl/The-utility-of-glomerular-C4d-immunostaining-in-renal-biopsies-in-patients-with-immunoglobulin-A-nephropathy-A-clinicopathological-study,55,30490,1,1.htmlIgA nephropathy C4d staining outcome of IgA nephropathy |
| spellingShingle | Małgorzata Wągrowska-Danilewicz Marian Danilewicz The utility of glomerular C4d immunostaining in renal biopsies in patients with immunoglobulin A nephropathy. A clinicopathological study Polish Journal of Pathology IgA nephropathy C4d staining outcome of IgA nephropathy |
| title | The utility of glomerular C4d immunostaining in renal biopsies in patients with immunoglobulin A nephropathy. A clinicopathological study |
| title_full | The utility of glomerular C4d immunostaining in renal biopsies in patients with immunoglobulin A nephropathy. A clinicopathological study |
| title_fullStr | The utility of glomerular C4d immunostaining in renal biopsies in patients with immunoglobulin A nephropathy. A clinicopathological study |
| title_full_unstemmed | The utility of glomerular C4d immunostaining in renal biopsies in patients with immunoglobulin A nephropathy. A clinicopathological study |
| title_short | The utility of glomerular C4d immunostaining in renal biopsies in patients with immunoglobulin A nephropathy. A clinicopathological study |
| title_sort | utility of glomerular c4d immunostaining in renal biopsies in patients with immunoglobulin a nephropathy a clinicopathological study |
| topic | IgA nephropathy C4d staining outcome of IgA nephropathy |
| url | https://www.termedia.pl/The-utility-of-glomerular-C4d-immunostaining-in-renal-biopsies-in-patients-with-immunoglobulin-A-nephropathy-A-clinicopathological-study,55,30490,1,1.html |
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