Viral infections in wheezing disorders
Over the past year, studies into virus-induced wheeze in children have shifted towards investigations that examine the mechanisms by which respiratory viruses cause wheeze and an increase in studies examining the effects of novel interventions to reduce wheezing exacerbations. Studies on rhinovirus...
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| Format: | Article |
| Language: | English |
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European Respiratory Society
2018-04-01
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| Series: | European Respiratory Review |
| Online Access: | http://err.ersjournals.com/content/27/147/170133.full |
| _version_ | 1818097126353141760 |
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| author | Peter Le Souëf |
| author_facet | Peter Le Souëf |
| author_sort | Peter Le Souëf |
| collection | DOAJ |
| description | Over the past year, studies into virus-induced wheeze in children have shifted towards investigations that examine the mechanisms by which respiratory viruses cause wheeze and an increase in studies examining the effects of novel interventions to reduce wheezing exacerbations. Studies on rhinovirus species (RV)-C infection have found that this is associated with a decrease in expression of CDHR3, the cellular receptor specific for this virus, and a decrease in interferon-β expression, both of which are likely to favour RV-C infection. Recent clinical trials in children have found a decrease in wheezing exacerbations with both anti-respiratory syncytial virus antibody and anti-immunoglobulin E antibody therapy, and a clinical trial of prednisolone in children with their first RV-induced wheeze showed that only those with an RV viral count >7000 copies·mL−1 responded. Further studies on the effects of bacterial lysates on immune system function continue to support the potential of this approach to reduce virus-induced wheezing exacerbations in children. These studies and many previous investigations into immunomodulation using bacterial lysates have led to the funding and commencement of a large study in which long-term administration of a bacterial lysate in young children will be assessed for its ability to prevent asthma. |
| first_indexed | 2024-12-10T23:15:34Z |
| format | Article |
| id | doaj.art-a515ad53531b4899a78de4704e3a4bbe |
| institution | Directory Open Access Journal |
| issn | 0905-9180 1600-0617 |
| language | English |
| last_indexed | 2024-12-10T23:15:34Z |
| publishDate | 2018-04-01 |
| publisher | European Respiratory Society |
| record_format | Article |
| series | European Respiratory Review |
| spelling | doaj.art-a515ad53531b4899a78de4704e3a4bbe2022-12-22T01:29:51ZengEuropean Respiratory SocietyEuropean Respiratory Review0905-91801600-06172018-04-012714710.1183/16000617.0133-20170133-2017Viral infections in wheezing disordersPeter Le Souëf0 Faculty of Health and Medical Sciences, Dept of Respiratory Medicine, Child and Adolescent Health Service, University of Western Australia, Perth, Australia Over the past year, studies into virus-induced wheeze in children have shifted towards investigations that examine the mechanisms by which respiratory viruses cause wheeze and an increase in studies examining the effects of novel interventions to reduce wheezing exacerbations. Studies on rhinovirus species (RV)-C infection have found that this is associated with a decrease in expression of CDHR3, the cellular receptor specific for this virus, and a decrease in interferon-β expression, both of which are likely to favour RV-C infection. Recent clinical trials in children have found a decrease in wheezing exacerbations with both anti-respiratory syncytial virus antibody and anti-immunoglobulin E antibody therapy, and a clinical trial of prednisolone in children with their first RV-induced wheeze showed that only those with an RV viral count >7000 copies·mL−1 responded. Further studies on the effects of bacterial lysates on immune system function continue to support the potential of this approach to reduce virus-induced wheezing exacerbations in children. These studies and many previous investigations into immunomodulation using bacterial lysates have led to the funding and commencement of a large study in which long-term administration of a bacterial lysate in young children will be assessed for its ability to prevent asthma.http://err.ersjournals.com/content/27/147/170133.full |
| spellingShingle | Peter Le Souëf Viral infections in wheezing disorders European Respiratory Review |
| title | Viral infections in wheezing disorders |
| title_full | Viral infections in wheezing disorders |
| title_fullStr | Viral infections in wheezing disorders |
| title_full_unstemmed | Viral infections in wheezing disorders |
| title_short | Viral infections in wheezing disorders |
| title_sort | viral infections in wheezing disorders |
| url | http://err.ersjournals.com/content/27/147/170133.full |
| work_keys_str_mv | AT peterlesouef viralinfectionsinwheezingdisorders |