The Effect of Ethanol Extract of Aerial Parts of Salvia hydrangea L. on Plasma Biochemical Factors in Male Rats with Hypercholesterolemia
Background and Objectives: Medicinal plants have been used since ancient times to treat obesity, hyperlipidemia, and metabolic diseases. In the present research, the effect of extract of aerial parts of Salvia hydrangea on changes in body weight and liver and kidney function tests, were evaluated in...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | fas |
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Qom University of Medical Sciences
2016-06-01
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| Series: | Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum |
| Subjects: | |
| Online Access: | http://journal.muq.ac.ir/browse.php?a_code=A-10-1-525&slc_lang=en&sid=1 |
| _version_ | 1818722743945789440 |
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| author | Heydar Aqababa Mohammad Ali Chobineh Ali Zarei Saeed Changizi Ashtiyani |
| author_facet | Heydar Aqababa Mohammad Ali Chobineh Ali Zarei Saeed Changizi Ashtiyani |
| author_sort | Heydar Aqababa |
| collection | DOAJ |
| description | Background and Objectives: Medicinal plants have been used since ancient times to treat obesity, hyperlipidemia, and metabolic diseases. In the present research, the effect of extract of aerial parts of Salvia hydrangea on changes in body weight and liver and kidney function tests, were evaluated in hypercholesterolemia rats.
Methods: In this study, 40 male Wistar rats were assigned to 5 groups (n=8): Control group with normal diet, hyperlipidemia group with fatty diet, and hyperlipidemia experimental groups that, respectively, received, 100mg/kg (minimum dose), 200mg/kg (average dose), and 400mg/kg (maximum dose) of ethanol extract of Salvia hydrangeas by gavage. At the end of this period (35 days), blood sampling was performed to measure the levels of cholesterol, creatinine, blood urea nitrogen, bilirubin, albumin, total protein, alanine aminotransferase (ALT), aspartate aminotransferase (AST(, and alkaline phosphatase (ALP). The data were analyzed using t-, one-way ANOVA, and Tukey tests. Level of significance was considered at p<0.05.
Results: The levels of ALP, ALT, and cholesterol had a significant increase in the hypercholesterolemia group compared to the control group (p<0.05). Also, the levels of ALP, ALT, AST, and cholesterol decreased in the experimental group receiving extract, and the albumin level significantly increased (p<0.05).
Conclusion: According to the results of this study, Salvia hydrangea extract can be effective in the improvement of fatty liver function by lowering the levels of cholesterol and liver enzymes. This role is likely due to antioxidant substances present in the extract, which inhibits the synthesis of cholesterol. |
| first_indexed | 2024-12-17T20:59:29Z |
| format | Article |
| id | doaj.art-a515dfd42add453cb122bb3de2c65f47 |
| institution | Directory Open Access Journal |
| issn | 1735-7799 2008-1375 |
| language | fas |
| last_indexed | 2024-12-17T20:59:29Z |
| publishDate | 2016-06-01 |
| publisher | Qom University of Medical Sciences |
| record_format | Article |
| series | Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum |
| spelling | doaj.art-a515dfd42add453cb122bb3de2c65f472022-12-21T21:32:47ZfasQom University of Medical SciencesMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum1735-77992008-13752016-06-011047885The Effect of Ethanol Extract of Aerial Parts of Salvia hydrangea L. on Plasma Biochemical Factors in Male Rats with HypercholesterolemiaHeydar Aqababa0Mohammad Ali Chobineh1Ali Zarei2Saeed Changizi Ashtiyani34 Department of Biology, Arsanjan Branch, Islamic Azad University, Arsanjan, Iran. Department of Biology, Arsanjan Branch, Islamic Azad University, Arsanjan, Iran. 2Young Researchers & Elite Club, Abadeh Branch, Islamic Azad University, Abadeh, Iran. 3Department of Physiology, Arak University of Medical Sciences, Arak, Iran. Background and Objectives: Medicinal plants have been used since ancient times to treat obesity, hyperlipidemia, and metabolic diseases. In the present research, the effect of extract of aerial parts of Salvia hydrangea on changes in body weight and liver and kidney function tests, were evaluated in hypercholesterolemia rats. Methods: In this study, 40 male Wistar rats were assigned to 5 groups (n=8): Control group with normal diet, hyperlipidemia group with fatty diet, and hyperlipidemia experimental groups that, respectively, received, 100mg/kg (minimum dose), 200mg/kg (average dose), and 400mg/kg (maximum dose) of ethanol extract of Salvia hydrangeas by gavage. At the end of this period (35 days), blood sampling was performed to measure the levels of cholesterol, creatinine, blood urea nitrogen, bilirubin, albumin, total protein, alanine aminotransferase (ALT), aspartate aminotransferase (AST(, and alkaline phosphatase (ALP). The data were analyzed using t-, one-way ANOVA, and Tukey tests. Level of significance was considered at p<0.05. Results: The levels of ALP, ALT, and cholesterol had a significant increase in the hypercholesterolemia group compared to the control group (p<0.05). Also, the levels of ALP, ALT, AST, and cholesterol decreased in the experimental group receiving extract, and the albumin level significantly increased (p<0.05). Conclusion: According to the results of this study, Salvia hydrangea extract can be effective in the improvement of fatty liver function by lowering the levels of cholesterol and liver enzymes. This role is likely due to antioxidant substances present in the extract, which inhibits the synthesis of cholesterol.http://journal.muq.ac.ir/browse.php?a_code=A-10-1-525&slc_lang=en&sid=1 salvia hydrangea liver creatinine hypercholesterolemia rats. |
| spellingShingle | Heydar Aqababa Mohammad Ali Chobineh Ali Zarei Saeed Changizi Ashtiyani The Effect of Ethanol Extract of Aerial Parts of Salvia hydrangea L. on Plasma Biochemical Factors in Male Rats with Hypercholesterolemia Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum salvia hydrangea liver creatinine hypercholesterolemia rats. |
| title | The Effect of Ethanol Extract of Aerial Parts of Salvia hydrangea L. on Plasma Biochemical Factors in Male Rats with Hypercholesterolemia |
| title_full | The Effect of Ethanol Extract of Aerial Parts of Salvia hydrangea L. on Plasma Biochemical Factors in Male Rats with Hypercholesterolemia |
| title_fullStr | The Effect of Ethanol Extract of Aerial Parts of Salvia hydrangea L. on Plasma Biochemical Factors in Male Rats with Hypercholesterolemia |
| title_full_unstemmed | The Effect of Ethanol Extract of Aerial Parts of Salvia hydrangea L. on Plasma Biochemical Factors in Male Rats with Hypercholesterolemia |
| title_short | The Effect of Ethanol Extract of Aerial Parts of Salvia hydrangea L. on Plasma Biochemical Factors in Male Rats with Hypercholesterolemia |
| title_sort | effect of ethanol extract of aerial parts of salvia hydrangea l on plasma biochemical factors in male rats with hypercholesterolemia |
| topic | salvia hydrangea liver creatinine hypercholesterolemia rats. |
| url | http://journal.muq.ac.ir/browse.php?a_code=A-10-1-525&slc_lang=en&sid=1 |
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