The hypermethylation of p16 gene exon 1 and exon 2: potential biomarkers for colorectal cancer and are associated with cancer pathological staging

The hypermethylation of p16 gene exon 1 and exon 2: potential biomarkers for colorectal cancer and are associated with cancer pathological staging

Abstract Background Tumor suppressor gene p16 promoter hypermethylation has been widely studied in colorectal cancer (CRC), yet its clinicopathological significance remains controversial. The methylation alterations of other regions within p16 gene are still rarely researched. The present study aime...

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Bibliographic Details
Main Authors: Xiaoxia Ye, Mingming Mo, Simin Xu, Qingjin Yang, Minhua Wu, Junjie Zhang, Bin Chen, Jian Li, Yu Zhong, Qionglin Huang, Chun Cai
Format: Article
Language:English
Published: BMC 2018-10-01
Series:BMC Cancer
Subjects:
p16 gene
Exon 1
Exon 2
DNA methylation
Colorectal cancer
Online Access:http://link.springer.com/article/10.1186/s12885-018-4921-5

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