How far the zone of heat-induced transient block extends beyond the lesion during RF catheter cardiac ablation
AbstractPurpose While radiofrequency catheter ablation (RFCA) creates a lesion consisting of the tissue points subjected to lethal heating, the sublethal heating (SH) undergone by the surrounding tissue can cause transient electrophysiological block. The size of the zone of heat-induced transient bl...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | International Journal of Hyperthermia |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/02656736.2022.2163310 |
| _version_ | 1827397148257288192 |
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| author | Juan J. Pérez Enrique Berjano Ana González-Suárez |
| author_facet | Juan J. Pérez Enrique Berjano Ana González-Suárez |
| author_sort | Juan J. Pérez |
| collection | DOAJ |
| description | AbstractPurpose While radiofrequency catheter ablation (RFCA) creates a lesion consisting of the tissue points subjected to lethal heating, the sublethal heating (SH) undergone by the surrounding tissue can cause transient electrophysiological block. The size of the zone of heat-induced transient block (HiTB) has not been quantified to date. Our objective was to use computer modeling to provide an initial estimate.Methods and materials We used previous experimental data together with the Arrhenius damage index (Ω) to fix the Ω values that delineate this zone: a lower limit of 0.1–0.4 and upper limit of 1.0 (lesion boundary). An RFCA computer model was used with different power-duration settings, catheter positions and electrode insertion depths, together with dispersion of the tissue’s electrical and thermal characteristics.Results The HiTB zone extends in depth to a minimum and maximum distance of 0.5 mm and 2 mm beyond the lesion limit, respectively, while its maximum width varies with the energy delivered, extending to a minimum of 0.6 mm and a maximum of 2.5 mm beyond the lesion, reaching 3.5 mm when high energy settings are used (25 W–20s, 500 J). The dispersion of the tissue’s thermal and electrical characteristics affects the size of the HiTB zone by ±0.3 mm in depth and ±0.5 mm in maximum width.Conclusions Our results suggest that the size of the zone of heat-induced transient block during RFCA could extend beyond the lesion limit by a maximum of 2 mm in depth and approximately 2.5 mm in width. |
| first_indexed | 2024-03-08T19:03:03Z |
| format | Article |
| id | doaj.art-a5177cd49d1b43cda6d0648a809b0f49 |
| institution | Directory Open Access Journal |
| issn | 0265-6736 1464-5157 |
| language | English |
| last_indexed | 2024-03-08T19:03:03Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | International Journal of Hyperthermia |
| spelling | doaj.art-a5177cd49d1b43cda6d0648a809b0f492023-12-28T04:15:43ZengTaylor & Francis GroupInternational Journal of Hyperthermia0265-67361464-51572023-12-0140110.1080/02656736.2022.2163310How far the zone of heat-induced transient block extends beyond the lesion during RF catheter cardiac ablationJuan J. Pérez0Enrique Berjano1Ana González-Suárez2BioMIT, Department of Electronic Engineering, Universitat Politècnica de València, Valencia, SpainBioMIT, Department of Electronic Engineering, Universitat Politècnica de València, Valencia, SpainSchool of Engineering, University of Galway, Galway, IrelandAbstractPurpose While radiofrequency catheter ablation (RFCA) creates a lesion consisting of the tissue points subjected to lethal heating, the sublethal heating (SH) undergone by the surrounding tissue can cause transient electrophysiological block. The size of the zone of heat-induced transient block (HiTB) has not been quantified to date. Our objective was to use computer modeling to provide an initial estimate.Methods and materials We used previous experimental data together with the Arrhenius damage index (Ω) to fix the Ω values that delineate this zone: a lower limit of 0.1–0.4 and upper limit of 1.0 (lesion boundary). An RFCA computer model was used with different power-duration settings, catheter positions and electrode insertion depths, together with dispersion of the tissue’s electrical and thermal characteristics.Results The HiTB zone extends in depth to a minimum and maximum distance of 0.5 mm and 2 mm beyond the lesion limit, respectively, while its maximum width varies with the energy delivered, extending to a minimum of 0.6 mm and a maximum of 2.5 mm beyond the lesion, reaching 3.5 mm when high energy settings are used (25 W–20s, 500 J). The dispersion of the tissue’s thermal and electrical characteristics affects the size of the HiTB zone by ±0.3 mm in depth and ±0.5 mm in maximum width.Conclusions Our results suggest that the size of the zone of heat-induced transient block during RFCA could extend beyond the lesion limit by a maximum of 2 mm in depth and approximately 2.5 mm in width.https://www.tandfonline.com/doi/10.1080/02656736.2022.2163310Cardiac ablationcomputer modelingmild hyperthermiamoderate heatingtransient block |
| spellingShingle | Juan J. Pérez Enrique Berjano Ana González-Suárez How far the zone of heat-induced transient block extends beyond the lesion during RF catheter cardiac ablation International Journal of Hyperthermia Cardiac ablation computer modeling mild hyperthermia moderate heating transient block |
| title | How far the zone of heat-induced transient block extends beyond the lesion during RF catheter cardiac ablation |
| title_full | How far the zone of heat-induced transient block extends beyond the lesion during RF catheter cardiac ablation |
| title_fullStr | How far the zone of heat-induced transient block extends beyond the lesion during RF catheter cardiac ablation |
| title_full_unstemmed | How far the zone of heat-induced transient block extends beyond the lesion during RF catheter cardiac ablation |
| title_short | How far the zone of heat-induced transient block extends beyond the lesion during RF catheter cardiac ablation |
| title_sort | how far the zone of heat induced transient block extends beyond the lesion during rf catheter cardiac ablation |
| topic | Cardiac ablation computer modeling mild hyperthermia moderate heating transient block |
| url | https://www.tandfonline.com/doi/10.1080/02656736.2022.2163310 |
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