Role of Gonadotropin-Releasing Hormone (GnRH) in Ovarian Cancer
The hypothalamus–pituitary–gonadal (HPG) axis is the endocrine regulation system that controls the woman’s cycle. The gonadotropin-releasing hormone (GnRH) plays the central role. In addition to the gonadotrophic cells of the pituitary, GnRH receptors are expressed in other reproductive organs, such...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-02-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/10/2/437 |
| _version_ | 1797396065592279040 |
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| author | Carsten Gründker Günter Emons |
| author_facet | Carsten Gründker Günter Emons |
| author_sort | Carsten Gründker |
| collection | DOAJ |
| description | The hypothalamus–pituitary–gonadal (HPG) axis is the endocrine regulation system that controls the woman’s cycle. The gonadotropin-releasing hormone (GnRH) plays the central role. In addition to the gonadotrophic cells of the pituitary, GnRH receptors are expressed in other reproductive organs, such as the ovary and in tumors originating from the ovary. In ovarian cancer, GnRH is involved in the regulation of proliferation and metastasis. The effects on ovarian tumors can be indirect or direct. GnRH acts indirectly via the HPG axis and directly via GnRH receptors on the surface of ovarian cancer cells. In this systematic review, we will give an overview of the role of GnRH in ovarian cancer development, progression and therapy. |
| first_indexed | 2024-03-09T00:45:54Z |
| format | Article |
| id | doaj.art-a51a066e65a441dbb6ddf5ee32f36528 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-09T00:45:54Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-a51a066e65a441dbb6ddf5ee32f365282023-12-11T17:33:21ZengMDPI AGCells2073-44092021-02-0110243710.3390/cells10020437Role of Gonadotropin-Releasing Hormone (GnRH) in Ovarian CancerCarsten Gründker0Günter Emons1Department of Gynecology and Obstetrics, University Medicine Göttingen, 37075 Göttingen, GermanyDepartment of Gynecology and Obstetrics, University Medicine Göttingen, 37075 Göttingen, GermanyThe hypothalamus–pituitary–gonadal (HPG) axis is the endocrine regulation system that controls the woman’s cycle. The gonadotropin-releasing hormone (GnRH) plays the central role. In addition to the gonadotrophic cells of the pituitary, GnRH receptors are expressed in other reproductive organs, such as the ovary and in tumors originating from the ovary. In ovarian cancer, GnRH is involved in the regulation of proliferation and metastasis. The effects on ovarian tumors can be indirect or direct. GnRH acts indirectly via the HPG axis and directly via GnRH receptors on the surface of ovarian cancer cells. In this systematic review, we will give an overview of the role of GnRH in ovarian cancer development, progression and therapy.https://www.mdpi.com/2073-4409/10/2/437ovarian cancergonadotropin-releasing hormoneGnRHLHRH |
| spellingShingle | Carsten Gründker Günter Emons Role of Gonadotropin-Releasing Hormone (GnRH) in Ovarian Cancer Cells ovarian cancer gonadotropin-releasing hormone GnRH LHRH |
| title | Role of Gonadotropin-Releasing Hormone (GnRH) in Ovarian Cancer |
| title_full | Role of Gonadotropin-Releasing Hormone (GnRH) in Ovarian Cancer |
| title_fullStr | Role of Gonadotropin-Releasing Hormone (GnRH) in Ovarian Cancer |
| title_full_unstemmed | Role of Gonadotropin-Releasing Hormone (GnRH) in Ovarian Cancer |
| title_short | Role of Gonadotropin-Releasing Hormone (GnRH) in Ovarian Cancer |
| title_sort | role of gonadotropin releasing hormone gnrh in ovarian cancer |
| topic | ovarian cancer gonadotropin-releasing hormone GnRH LHRH |
| url | https://www.mdpi.com/2073-4409/10/2/437 |
| work_keys_str_mv | AT carstengrundker roleofgonadotropinreleasinghormonegnrhinovariancancer AT gunteremons roleofgonadotropinreleasinghormonegnrhinovariancancer |