Incidence and risk factors of suicide among patients with pancreatic cancer: A population-based analysis from 2000 to 2018
BackgroundThe rate of suicide within one year after diagnosis in pancreatic cancer patients are high, but suicide studies based on the current large-scale data are still a vacancy. Our study aimed to determine, compared to the general population, the standardized mortality ratios (SMRs) of suicide a...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.972908/full |
| _version_ | 1811284007209402368 |
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| author | Yifei Ma Yifei Ma Jun Lyu Bao Yang Bao Yang Tianao Yan Tianao Yan Qingyong Ma Zheng Wu Zheng Wang Zheng Wang Hairong He |
| author_facet | Yifei Ma Yifei Ma Jun Lyu Bao Yang Bao Yang Tianao Yan Tianao Yan Qingyong Ma Zheng Wu Zheng Wang Zheng Wang Hairong He |
| author_sort | Yifei Ma |
| collection | DOAJ |
| description | BackgroundThe rate of suicide within one year after diagnosis in pancreatic cancer patients are high, but suicide studies based on the current large-scale data are still a vacancy. Our study aimed to determine, compared to the general population, the standardized mortality ratios (SMRs) of suicide and risk factors associated with pancreatic cancer patients committing suicide to provide clues for prevention.MethodsWe collected 199,604 patients diagnosed with pancreatic cancer between 2000 and 2018 from the SEER database. Multivariate logistic regression and multivariate Cox regression were applied to determine the risk factors independently affecting the suicide outcome of pancreatic cancer patients.ResultsA total of 180 suicide deaths were observed in the cohort, yielding an overall suicide rate of 88.05 per 100,000 person-years and an SMR of 6.43. In multivariate analyses, males (HR: 12.798, 95% CI: 7.471-21.923), unmarried (HR: 1.826, 95% CI: 1.205-2.767), and divorced, separated or widowed (HR: 1.779, 95% CI: 1.230-2.572) were found associated with a higher risk of suicide. While race black (HR: 0.250, 95% CI: 0.110-0.567), diagnosed with pancreatic neuroendocrine tumor (HR: 0.487, 95% CI: 0.276-0.859), received chemotherapy (HR: 0.456, 95% CI: 0.323-0.646), and received surgical procedures (HR: 0.553, 95% CI: 0.342-0.895) were indicated might protective factors.ConclusionsThe 199,604 pancreatic cancer patients diagnosed between 2000 and 2018 had an overall suicide rate of 88.05 per 100,000 person-years and an SMR of 6.43 compared to the U.S. general population. Male, white, unmarried, and diagnosed with pancreatic adenocarcinoma patients were associated with a higher risk of suicide, while cancer-directed surgery and chemotherapy might indicate protective factors. The screening and prevention process should be enhanced for pancreatic cancer patients with adverse risk factors. Moreover, it is reasonable to assume that timely cancer-directed treatment might help reduce the subsequent suicide risk of pancreatic cancer patients. |
| first_indexed | 2024-04-13T02:22:09Z |
| format | Article |
| id | doaj.art-a51b7cac516f4f24bdb8f2bd4fac3233 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-13T02:22:09Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-a51b7cac516f4f24bdb8f2bd4fac32332022-12-22T03:06:55ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-08-011210.3389/fonc.2022.972908972908Incidence and risk factors of suicide among patients with pancreatic cancer: A population-based analysis from 2000 to 2018Yifei Ma0Yifei Ma1Jun Lyu2Bao Yang3Bao Yang4Tianao Yan5Tianao Yan6Qingyong Ma7Zheng Wu8Zheng Wang9Zheng Wang10Hairong He11Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaDepartment of Surgical Intensive Care Unit, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaDepartment of Clinical Research, The First Affiliated Hospital of Jinan University, Guangzhou, ChinaDepartment of Hepatobiliary Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaDepartment of Surgical Intensive Care Unit, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaDepartment of Hepatobiliary Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaDepartment of Surgical Intensive Care Unit, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaDepartment of Hepatobiliary Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaDepartment of Hepatobiliary Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaDepartment of Hepatobiliary Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaDepartment of Surgical Intensive Care Unit, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaDepartment of Clinical Research Center, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaBackgroundThe rate of suicide within one year after diagnosis in pancreatic cancer patients are high, but suicide studies based on the current large-scale data are still a vacancy. Our study aimed to determine, compared to the general population, the standardized mortality ratios (SMRs) of suicide and risk factors associated with pancreatic cancer patients committing suicide to provide clues for prevention.MethodsWe collected 199,604 patients diagnosed with pancreatic cancer between 2000 and 2018 from the SEER database. Multivariate logistic regression and multivariate Cox regression were applied to determine the risk factors independently affecting the suicide outcome of pancreatic cancer patients.ResultsA total of 180 suicide deaths were observed in the cohort, yielding an overall suicide rate of 88.05 per 100,000 person-years and an SMR of 6.43. In multivariate analyses, males (HR: 12.798, 95% CI: 7.471-21.923), unmarried (HR: 1.826, 95% CI: 1.205-2.767), and divorced, separated or widowed (HR: 1.779, 95% CI: 1.230-2.572) were found associated with a higher risk of suicide. While race black (HR: 0.250, 95% CI: 0.110-0.567), diagnosed with pancreatic neuroendocrine tumor (HR: 0.487, 95% CI: 0.276-0.859), received chemotherapy (HR: 0.456, 95% CI: 0.323-0.646), and received surgical procedures (HR: 0.553, 95% CI: 0.342-0.895) were indicated might protective factors.ConclusionsThe 199,604 pancreatic cancer patients diagnosed between 2000 and 2018 had an overall suicide rate of 88.05 per 100,000 person-years and an SMR of 6.43 compared to the U.S. general population. Male, white, unmarried, and diagnosed with pancreatic adenocarcinoma patients were associated with a higher risk of suicide, while cancer-directed surgery and chemotherapy might indicate protective factors. The screening and prevention process should be enhanced for pancreatic cancer patients with adverse risk factors. Moreover, it is reasonable to assume that timely cancer-directed treatment might help reduce the subsequent suicide risk of pancreatic cancer patients.https://www.frontiersin.org/articles/10.3389/fonc.2022.972908/fullpancreatic cancerthe SEER databaseSMRsrisk factorssuicide |
| spellingShingle | Yifei Ma Yifei Ma Jun Lyu Bao Yang Bao Yang Tianao Yan Tianao Yan Qingyong Ma Zheng Wu Zheng Wang Zheng Wang Hairong He Incidence and risk factors of suicide among patients with pancreatic cancer: A population-based analysis from 2000 to 2018 Frontiers in Oncology pancreatic cancer the SEER database SMRs risk factors suicide |
| title | Incidence and risk factors of suicide among patients with pancreatic cancer: A population-based analysis from 2000 to 2018 |
| title_full | Incidence and risk factors of suicide among patients with pancreatic cancer: A population-based analysis from 2000 to 2018 |
| title_fullStr | Incidence and risk factors of suicide among patients with pancreatic cancer: A population-based analysis from 2000 to 2018 |
| title_full_unstemmed | Incidence and risk factors of suicide among patients with pancreatic cancer: A population-based analysis from 2000 to 2018 |
| title_short | Incidence and risk factors of suicide among patients with pancreatic cancer: A population-based analysis from 2000 to 2018 |
| title_sort | incidence and risk factors of suicide among patients with pancreatic cancer a population based analysis from 2000 to 2018 |
| topic | pancreatic cancer the SEER database SMRs risk factors suicide |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.972908/full |
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