Oncologic outcome of multimodality treatment for sinonasal malignancies: An 18-year experience
PurposeThe aim of this study was to retrospectively evaluate the oncologic outcomes of sinonasal malignancies (SNMs) of various histologic subtypes and investigate the impact of multimodality treatment on prognosis of SNM.MethodsSNM patients treated with curative-intent surgery from 2000 to 2018 wer...
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| Language: | English |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.958142/full |
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| author | Meng-Yu Chen Xin Wen Yi Wei Lin Chen Zi-Xuan Huang Tong Lu Nian-Zhen Zheng Jian Li Wei-Ping Wen Wei-Ping Wen Yi-Hui Wen |
| author_facet | Meng-Yu Chen Xin Wen Yi Wei Lin Chen Zi-Xuan Huang Tong Lu Nian-Zhen Zheng Jian Li Wei-Ping Wen Wei-Ping Wen Yi-Hui Wen |
| author_sort | Meng-Yu Chen |
| collection | DOAJ |
| description | PurposeThe aim of this study was to retrospectively evaluate the oncologic outcomes of sinonasal malignancies (SNMs) of various histologic subtypes and investigate the impact of multimodality treatment on prognosis of SNM.MethodsSNM patients treated with curative-intent surgery from 2000 to 2018 were included. The primary outcomes were overall survival (OS). Survival was then assessed through Cox proportional hazards models.ResultsThree hundred and three patients were eligible for the analysis. The 5-year OS and event-free survival (EFS) were 61.0% (95% CI: 55.4%–67.1%) and 46.2% (95% CI: 40.4%–52.7%). The 5-year OS was the worst for malignant melanoma and the best for adenocarcinoma. Patients who received surgery had better OS than those who only received radiotherapy and/or chemotherapy. Endoscopic surgery had better OS than the open approach (p < 0.05). Microscopically margin-negative resection (R0 resection) significantly benefited OS and EFS (p < 0.001). No significant difference in OS was observed between patients who received macroscopic complete resection (R1 resection) followed by adjuvant therapy and patients who received R0 resection. Older age (HR = 1.02, p = 0.02), R1 resection (HR = 1.99, p = 0.02), sinonasal surgical history of more than 3 months before diagnosis (HR = 2.77, p = 0.007), and radiotherapy history (HR = 3, p = 0.006) are risk factors for worse EFS.ConclusionsCurative-intent surgery is irreplaceable in the treatment of SNM. The endoscopic approach is an effective alternative to the open approach. EFS is worse among patients with older age, R1 resection, sinonasal surgical history of more than 3 months before diagnosis, and radiotherapy history. |
| first_indexed | 2024-12-10T12:40:24Z |
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| id | doaj.art-a51d0a23b6b24662a8bd3f129b07aae9 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-10T12:40:24Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-a51d0a23b6b24662a8bd3f129b07aae92022-12-22T01:48:34ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-09-011210.3389/fonc.2022.958142958142Oncologic outcome of multimodality treatment for sinonasal malignancies: An 18-year experienceMeng-Yu Chen0Xin Wen1Yi Wei2Lin Chen3Zi-Xuan Huang4Tong Lu5Nian-Zhen Zheng6Jian Li7Wei-Ping Wen8Wei-Ping Wen9Yi-Hui Wen10Department of Otolaryngology, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou Key Laboratory of Otorhinolaryngology, Otorhinolaryngology Institute of Sun Yat-sen University, Guangzhou, ChinaDepartment of Otolaryngology, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou Key Laboratory of Otorhinolaryngology, Otorhinolaryngology Institute of Sun Yat-sen University, Guangzhou, ChinaDepartment of Otolaryngology, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou Key Laboratory of Otorhinolaryngology, Otorhinolaryngology Institute of Sun Yat-sen University, Guangzhou, ChinaDepartment of Otolaryngology, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou Key Laboratory of Otorhinolaryngology, Otorhinolaryngology Institute of Sun Yat-sen University, Guangzhou, ChinaDepartment of Otolaryngology, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou Key Laboratory of Otorhinolaryngology, Otorhinolaryngology Institute of Sun Yat-sen University, Guangzhou, ChinaDepartment of Otolaryngology, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou Key Laboratory of Otorhinolaryngology, Otorhinolaryngology Institute of Sun Yat-sen University, Guangzhou, ChinaDepartment of Otolaryngology, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou Key Laboratory of Otorhinolaryngology, Otorhinolaryngology Institute of Sun Yat-sen University, Guangzhou, ChinaDepartment of Otolaryngology, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou Key Laboratory of Otorhinolaryngology, Otorhinolaryngology Institute of Sun Yat-sen University, Guangzhou, ChinaDepartment of Otolaryngology, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou Key Laboratory of Otorhinolaryngology, Otorhinolaryngology Institute of Sun Yat-sen University, Guangzhou, ChinaDepartment of Otolaryngology, the Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, ChinaDepartment of Otolaryngology, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou Key Laboratory of Otorhinolaryngology, Otorhinolaryngology Institute of Sun Yat-sen University, Guangzhou, ChinaPurposeThe aim of this study was to retrospectively evaluate the oncologic outcomes of sinonasal malignancies (SNMs) of various histologic subtypes and investigate the impact of multimodality treatment on prognosis of SNM.MethodsSNM patients treated with curative-intent surgery from 2000 to 2018 were included. The primary outcomes were overall survival (OS). Survival was then assessed through Cox proportional hazards models.ResultsThree hundred and three patients were eligible for the analysis. The 5-year OS and event-free survival (EFS) were 61.0% (95% CI: 55.4%–67.1%) and 46.2% (95% CI: 40.4%–52.7%). The 5-year OS was the worst for malignant melanoma and the best for adenocarcinoma. Patients who received surgery had better OS than those who only received radiotherapy and/or chemotherapy. Endoscopic surgery had better OS than the open approach (p < 0.05). Microscopically margin-negative resection (R0 resection) significantly benefited OS and EFS (p < 0.001). No significant difference in OS was observed between patients who received macroscopic complete resection (R1 resection) followed by adjuvant therapy and patients who received R0 resection. Older age (HR = 1.02, p = 0.02), R1 resection (HR = 1.99, p = 0.02), sinonasal surgical history of more than 3 months before diagnosis (HR = 2.77, p = 0.007), and radiotherapy history (HR = 3, p = 0.006) are risk factors for worse EFS.ConclusionsCurative-intent surgery is irreplaceable in the treatment of SNM. The endoscopic approach is an effective alternative to the open approach. EFS is worse among patients with older age, R1 resection, sinonasal surgical history of more than 3 months before diagnosis, and radiotherapy history.https://www.frontiersin.org/articles/10.3389/fonc.2022.958142/fullSinonasal malignanciesendoscopic surgeryanterior skull baseparanasal sinussurgical margin |
| spellingShingle | Meng-Yu Chen Xin Wen Yi Wei Lin Chen Zi-Xuan Huang Tong Lu Nian-Zhen Zheng Jian Li Wei-Ping Wen Wei-Ping Wen Yi-Hui Wen Oncologic outcome of multimodality treatment for sinonasal malignancies: An 18-year experience Frontiers in Oncology Sinonasal malignancies endoscopic surgery anterior skull base paranasal sinus surgical margin |
| title | Oncologic outcome of multimodality treatment for sinonasal malignancies: An 18-year experience |
| title_full | Oncologic outcome of multimodality treatment for sinonasal malignancies: An 18-year experience |
| title_fullStr | Oncologic outcome of multimodality treatment for sinonasal malignancies: An 18-year experience |
| title_full_unstemmed | Oncologic outcome of multimodality treatment for sinonasal malignancies: An 18-year experience |
| title_short | Oncologic outcome of multimodality treatment for sinonasal malignancies: An 18-year experience |
| title_sort | oncologic outcome of multimodality treatment for sinonasal malignancies an 18 year experience |
| topic | Sinonasal malignancies endoscopic surgery anterior skull base paranasal sinus surgical margin |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.958142/full |
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