Impact of HIV co-infection on the evolution and transmission of multidrug-resistant tuberculosis
The tuberculosis (TB) epidemic is fueled by a parallel Human Immunodeficiency Virus (HIV) epidemic, but it remains unclear to what extent the HIV epidemic has been a driver for drug resistance in Mycobacterium tuberculosis (Mtb). Here we assess the impact of HIV co-infection on the emergence of resi...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2016-08-01
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| Series: | eLife |
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| Online Access: | https://elifesciences.org/articles/16644 |
| _version_ | 1818019786844536832 |
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| author | Vegard Eldholm Adrien Rieux Johana Monteserin Julia Montana Lopez Domingo Palmero Beatriz Lopez Viviana Ritacco Xavier Didelot Francois Balloux |
| author_facet | Vegard Eldholm Adrien Rieux Johana Monteserin Julia Montana Lopez Domingo Palmero Beatriz Lopez Viviana Ritacco Xavier Didelot Francois Balloux |
| author_sort | Vegard Eldholm |
| collection | DOAJ |
| description | The tuberculosis (TB) epidemic is fueled by a parallel Human Immunodeficiency Virus (HIV) epidemic, but it remains unclear to what extent the HIV epidemic has been a driver for drug resistance in Mycobacterium tuberculosis (Mtb). Here we assess the impact of HIV co-infection on the emergence of resistance and transmission of Mtb in the largest outbreak of multidrug-resistant TB in South America to date. By combining Bayesian evolutionary analyses and the reconstruction of transmission networks utilizing a new model optimized for TB, we find that HIV co-infection does not significantly affect the transmissibility or the mutation rate of Mtb within patients and was not associated with increased emergence of resistance within patients. Our results indicate that the HIV epidemic serves as an amplifier of TB outbreaks by providing a reservoir of susceptible hosts, but that HIV co-infection is not a direct driver for the emergence and transmission of resistant strains. |
| first_indexed | 2024-04-14T07:55:57Z |
| format | Article |
| id | doaj.art-a51f490836bd460c8cf0f1a95f7169aa |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-14T07:55:57Z |
| publishDate | 2016-08-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-a51f490836bd460c8cf0f1a95f7169aa2022-12-22T02:05:03ZengeLife Sciences Publications LtdeLife2050-084X2016-08-01510.7554/eLife.16644Impact of HIV co-infection on the evolution and transmission of multidrug-resistant tuberculosisVegard Eldholm0https://orcid.org/0000-0001-6721-3375Adrien Rieux1Johana Monteserin2Julia Montana Lopez3Domingo Palmero4Beatriz Lopez5Viviana Ritacco6Xavier Didelot7https://orcid.org/0000-0003-1885-500XFrancois Balloux8Division of Infectious Disease Control, Norwegian Institute of Public Health, Oslo, NorwayUCL Genetics Institute, University College London, London, United KingdomInstituto Nacional de Enfermedades Infecciosas, ANLIS Carlos Malbrán, Buenos Aires, Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, ArgentinaUCL Genetics Institute, University College London, London, United KingdomDivisión Tisioneumonología, Hospital Muñiz, Buenos Aires, ArgentinaInstituto Nacional de Enfermedades Infecciosas, ANLIS Carlos Malbrán, Buenos Aires, Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, ArgentinaInstituto Nacional de Enfermedades Infecciosas, ANLIS Carlos Malbrán, Buenos Aires, Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, ArgentinaDepartment of Infectious Disease Epidemiology, Imperial College London, London, United KingdomUCL Genetics Institute, University College London, London, United KingdomThe tuberculosis (TB) epidemic is fueled by a parallel Human Immunodeficiency Virus (HIV) epidemic, but it remains unclear to what extent the HIV epidemic has been a driver for drug resistance in Mycobacterium tuberculosis (Mtb). Here we assess the impact of HIV co-infection on the emergence of resistance and transmission of Mtb in the largest outbreak of multidrug-resistant TB in South America to date. By combining Bayesian evolutionary analyses and the reconstruction of transmission networks utilizing a new model optimized for TB, we find that HIV co-infection does not significantly affect the transmissibility or the mutation rate of Mtb within patients and was not associated with increased emergence of resistance within patients. Our results indicate that the HIV epidemic serves as an amplifier of TB outbreaks by providing a reservoir of susceptible hosts, but that HIV co-infection is not a direct driver for the emergence and transmission of resistant strains.https://elifesciences.org/articles/16644Mycobacterium tuberculosisantimicrobial resistanceHIVtransmission reconstructionepidemiologyevolution |
| spellingShingle | Vegard Eldholm Adrien Rieux Johana Monteserin Julia Montana Lopez Domingo Palmero Beatriz Lopez Viviana Ritacco Xavier Didelot Francois Balloux Impact of HIV co-infection on the evolution and transmission of multidrug-resistant tuberculosis eLife Mycobacterium tuberculosis antimicrobial resistance HIV transmission reconstruction epidemiology evolution |
| title | Impact of HIV co-infection on the evolution and transmission of multidrug-resistant tuberculosis |
| title_full | Impact of HIV co-infection on the evolution and transmission of multidrug-resistant tuberculosis |
| title_fullStr | Impact of HIV co-infection on the evolution and transmission of multidrug-resistant tuberculosis |
| title_full_unstemmed | Impact of HIV co-infection on the evolution and transmission of multidrug-resistant tuberculosis |
| title_short | Impact of HIV co-infection on the evolution and transmission of multidrug-resistant tuberculosis |
| title_sort | impact of hiv co infection on the evolution and transmission of multidrug resistant tuberculosis |
| topic | Mycobacterium tuberculosis antimicrobial resistance HIV transmission reconstruction epidemiology evolution |
| url | https://elifesciences.org/articles/16644 |
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