A review of the regulatory mechanisms of extracellular vesicles-mediated intercellular communication
Abstract Extracellular vesicles (EVs) are small, membrane-bound structures that are released from cells into the surrounding environment. These structures can be categorized as exosomes, microvesicles, or apoptotic vesicles, and they play an essential role in intercellular communication. These vesic...
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| Format: | Article |
| Language: | English |
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BMC
2023-04-01
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| Series: | Cell Communication and Signaling |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12964-023-01103-6 |
| _version_ | 1827966205921591296 |
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| author | Ya-Juan Liu Cheng Wang |
| author_facet | Ya-Juan Liu Cheng Wang |
| author_sort | Ya-Juan Liu |
| collection | DOAJ |
| description | Abstract Extracellular vesicles (EVs) are small, membrane-bound structures that are released from cells into the surrounding environment. These structures can be categorized as exosomes, microvesicles, or apoptotic vesicles, and they play an essential role in intercellular communication. These vesicles are attracting significant clinical interest as they offer the potential for drug delivery, disease diagnosis, and therapeutic intervention. To fully understand the regulation of intercellular communication through EVs, it is essential to investigate the underlying mechanisms. This review aims to provide a summary of the current knowledge on the intercellular communications involved in EV targeting, binding, and uptake, as well as the factors that influence these interactions. These factors include the properties of the EVs, the cellular environment, and the recipient cell. As the field of EV-related intercellular communication continues to expand and techniques improve, we can expect to uncover more information about this complex area, despite the current limitations in our knowledge. |
| first_indexed | 2024-04-09T17:46:20Z |
| format | Article |
| id | doaj.art-a5201e2661364e81992db0e8c77ae8d4 |
| institution | Directory Open Access Journal |
| issn | 1478-811X |
| language | English |
| last_indexed | 2024-04-09T17:46:20Z |
| publishDate | 2023-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Cell Communication and Signaling |
| spelling | doaj.art-a5201e2661364e81992db0e8c77ae8d42023-04-16T11:20:19ZengBMCCell Communication and Signaling1478-811X2023-04-0121111210.1186/s12964-023-01103-6A review of the regulatory mechanisms of extracellular vesicles-mediated intercellular communicationYa-Juan Liu0Cheng Wang1Key Laboratory of Molecular Target and Clinical Pharmacology, The NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences and the Fifth Affiliated Hospital, Guangzhou Medical UniversitySmurfit Institute of Genetics, Trinity College DublinAbstract Extracellular vesicles (EVs) are small, membrane-bound structures that are released from cells into the surrounding environment. These structures can be categorized as exosomes, microvesicles, or apoptotic vesicles, and they play an essential role in intercellular communication. These vesicles are attracting significant clinical interest as they offer the potential for drug delivery, disease diagnosis, and therapeutic intervention. To fully understand the regulation of intercellular communication through EVs, it is essential to investigate the underlying mechanisms. This review aims to provide a summary of the current knowledge on the intercellular communications involved in EV targeting, binding, and uptake, as well as the factors that influence these interactions. These factors include the properties of the EVs, the cellular environment, and the recipient cell. As the field of EV-related intercellular communication continues to expand and techniques improve, we can expect to uncover more information about this complex area, despite the current limitations in our knowledge.https://doi.org/10.1186/s12964-023-01103-6Extracellular vesicleExosomeIntercellular communicationEV uptakeEV biogenesis |
| spellingShingle | Ya-Juan Liu Cheng Wang A review of the regulatory mechanisms of extracellular vesicles-mediated intercellular communication Cell Communication and Signaling Extracellular vesicle Exosome Intercellular communication EV uptake EV biogenesis |
| title | A review of the regulatory mechanisms of extracellular vesicles-mediated intercellular communication |
| title_full | A review of the regulatory mechanisms of extracellular vesicles-mediated intercellular communication |
| title_fullStr | A review of the regulatory mechanisms of extracellular vesicles-mediated intercellular communication |
| title_full_unstemmed | A review of the regulatory mechanisms of extracellular vesicles-mediated intercellular communication |
| title_short | A review of the regulatory mechanisms of extracellular vesicles-mediated intercellular communication |
| title_sort | review of the regulatory mechanisms of extracellular vesicles mediated intercellular communication |
| topic | Extracellular vesicle Exosome Intercellular communication EV uptake EV biogenesis |
| url | https://doi.org/10.1186/s12964-023-01103-6 |
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