Effect of Diazepam on testicular tissue parameters and spermatogenesis in rats
Background and Objective: Sperm dysfunction and damage in spermatogenesis are the most common causes of male infertility. Diazepam is also a painkiller for benzodiazepines that can be addictive for a long time. This study was done to determine the effect of Diazepam on testicular tissue parameters a...
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| Format: | Article |
| Language: | fas |
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Golestan University of Medical Sciences
2020-04-01
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| Series: | مجله دانشگاه علوم پزشکی گرگان |
| Subjects: | |
| Online Access: | http://goums.ac.ir/journal/article-1-3512-en.html |
| _version_ | 1818530830974189568 |
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| author | Amir Bagher Ilkhani Maryam Tehranipour Saeedeh Zafar Balanezhad |
| author_facet | Amir Bagher Ilkhani Maryam Tehranipour Saeedeh Zafar Balanezhad |
| author_sort | Amir Bagher Ilkhani |
| collection | DOAJ |
| description | Background and Objective: Sperm dysfunction and damage in spermatogenesis are the most common causes of male infertility. Diazepam is also a painkiller for benzodiazepines that can be addictive for a long time. This study was done to determine the effect of Diazepam on testicular tissue parameters and spermatogenesis in Rats.
Methods: In this experimental study, 30 Wistar male rats with a 250-200 gram weight were randomly allocated into 5 groups. Experimental groups were received diazepam with doses of (2, 3, 4, 5 mg/kg/bw) for 14 days, intraperitonally. Serum physiology was injected in control group. The animals were anesthetized and the testes and epididymis ductus defran were removed for examination, sperm motility, and percentage of live sperm.
Results: Weight, large and small testicular diameter, percentage of live sperm and number of sperm moving forward were reduced with injection groups, at a dose of 3 mg / kg in all factors except the number of sperm moving forward in compared to the control group. In other groups, only testicular weight was significantly reduced at a dose of 2 mg/kg (P<0.05).
Conclusion: Diazepam can affect spermatogenesis process in rats. |
| first_indexed | 2024-12-11T17:24:40Z |
| format | Article |
| id | doaj.art-a5211ac264be423d8876fcc3b8a57ee3 |
| institution | Directory Open Access Journal |
| issn | 1562-4765 2008-4080 |
| language | fas |
| last_indexed | 2024-12-11T17:24:40Z |
| publishDate | 2020-04-01 |
| publisher | Golestan University of Medical Sciences |
| record_format | Article |
| series | مجله دانشگاه علوم پزشکی گرگان |
| spelling | doaj.art-a5211ac264be423d8876fcc3b8a57ee32022-12-22T00:57:00ZfasGolestan University of Medical Sciencesمجله دانشگاه علوم پزشکی گرگان1562-47652008-40802020-04-012215764Effect of Diazepam on testicular tissue parameters and spermatogenesis in ratsAmir Bagher Ilkhani0Maryam Tehranipour1Saeedeh Zafar Balanezhad2 M.Sc in Animal Biology, Department of Biology, Mashhad Branch, Islamic Azad University, Mashhad, Iran. Associate Professor, Department of Biology, Mashhad Branch, Islamic Azad University of Medical Sciences, Mashhad, Iran Assistant Professor, Department of Biology, Mashhad Branch, Islamic Azad University, Mashhad, Iran. Background and Objective: Sperm dysfunction and damage in spermatogenesis are the most common causes of male infertility. Diazepam is also a painkiller for benzodiazepines that can be addictive for a long time. This study was done to determine the effect of Diazepam on testicular tissue parameters and spermatogenesis in Rats. Methods: In this experimental study, 30 Wistar male rats with a 250-200 gram weight were randomly allocated into 5 groups. Experimental groups were received diazepam with doses of (2, 3, 4, 5 mg/kg/bw) for 14 days, intraperitonally. Serum physiology was injected in control group. The animals were anesthetized and the testes and epididymis ductus defran were removed for examination, sperm motility, and percentage of live sperm. Results: Weight, large and small testicular diameter, percentage of live sperm and number of sperm moving forward were reduced with injection groups, at a dose of 3 mg / kg in all factors except the number of sperm moving forward in compared to the control group. In other groups, only testicular weight was significantly reduced at a dose of 2 mg/kg (P<0.05). Conclusion: Diazepam can affect spermatogenesis process in rats.http://goums.ac.ir/journal/article-1-3512-en.htmldiazepamspermatogenesisfertilityrat |
| spellingShingle | Amir Bagher Ilkhani Maryam Tehranipour Saeedeh Zafar Balanezhad Effect of Diazepam on testicular tissue parameters and spermatogenesis in rats مجله دانشگاه علوم پزشکی گرگان diazepam spermatogenesis fertility rat |
| title | Effect of Diazepam on testicular tissue parameters and spermatogenesis in rats |
| title_full | Effect of Diazepam on testicular tissue parameters and spermatogenesis in rats |
| title_fullStr | Effect of Diazepam on testicular tissue parameters and spermatogenesis in rats |
| title_full_unstemmed | Effect of Diazepam on testicular tissue parameters and spermatogenesis in rats |
| title_short | Effect of Diazepam on testicular tissue parameters and spermatogenesis in rats |
| title_sort | effect of diazepam on testicular tissue parameters and spermatogenesis in rats |
| topic | diazepam spermatogenesis fertility rat |
| url | http://goums.ac.ir/journal/article-1-3512-en.html |
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