Dynamics of a Gel-Based Artificial Tear Film with an Emphasis on Dry Disease Treatment Applications
This paper discusses the spreading of gel-based ophthalmic formulation on the cornea surface assumed to be flat. We show that gel-based formulations exhibit rheological behaviors that the Herschel–Bulkley model can describe. The continuity and momentum equations are solved numerically using the mono...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-11-01
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| Series: | Gels |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2310-2861/7/4/215 |
| _version_ | 1797504359618052096 |
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| author | Hamza Mehdaoui Hamid Ait Abderrahmane Clement de Loubens Faïçal Nait Bouda Sofiane Hamani |
| author_facet | Hamza Mehdaoui Hamid Ait Abderrahmane Clement de Loubens Faïçal Nait Bouda Sofiane Hamani |
| author_sort | Hamza Mehdaoui |
| collection | DOAJ |
| description | This paper discusses the spreading of gel-based ophthalmic formulation on the cornea surface assumed to be flat. We show that gel-based formulations exhibit rheological behaviors that the Herschel–Bulkley model can describe. The continuity and momentum equations are solved numerically using the monofluid formulation and the volume-of-fluid (VOF) method. We investigated the influence of the rheological properties, namely the consistency, the yield stress, and the flow behavior index, on the spreading of a gel-based artificial tear over the cornea surface. We propose optimal values of these properties for efficient gel-based artificial tears. |
| first_indexed | 2024-03-10T04:03:31Z |
| format | Article |
| id | doaj.art-a5222e81f7c14014ad8376c7cea37509 |
| institution | Directory Open Access Journal |
| issn | 2310-2861 |
| language | English |
| last_indexed | 2024-03-10T04:03:31Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Gels |
| spelling | doaj.art-a5222e81f7c14014ad8376c7cea375092023-11-23T08:28:05ZengMDPI AGGels2310-28612021-11-017421510.3390/gels7040215Dynamics of a Gel-Based Artificial Tear Film with an Emphasis on Dry Disease Treatment ApplicationsHamza Mehdaoui0Hamid Ait Abderrahmane1Clement de Loubens2Faïçal Nait Bouda3Sofiane Hamani4Laboratoire de Mécanique, Matériaux et Energétique, Faculté de Technologie, Université de Bejaia, Bejaia 06000, AlgeriaDepartment of Mechanical Engineering, Khalifa University, Abu Dhabi P.O. Box 127788, United Arab EmiratesUniv. Grenoble Alpes, CNRS, Grenoble INP, LRP, 38000 Grenoble, FranceLaboratoire de Mécanique, Matériaux et Energétique, Faculté de Technologie, Université de Bejaia, Bejaia 06000, AlgeriaLaboratoire de Recherche en Hydraulique Appliquée et Environnement, Faculté de Technologie, Université de Bejaia, Bejaia 06000, AlgeriaThis paper discusses the spreading of gel-based ophthalmic formulation on the cornea surface assumed to be flat. We show that gel-based formulations exhibit rheological behaviors that the Herschel–Bulkley model can describe. The continuity and momentum equations are solved numerically using the monofluid formulation and the volume-of-fluid (VOF) method. We investigated the influence of the rheological properties, namely the consistency, the yield stress, and the flow behavior index, on the spreading of a gel-based artificial tear over the cornea surface. We propose optimal values of these properties for efficient gel-based artificial tears.https://www.mdpi.com/2310-2861/7/4/215dry eye diseasegel-based artificial tearsHerschel–Bulkley modeltear film breakupVOF method |
| spellingShingle | Hamza Mehdaoui Hamid Ait Abderrahmane Clement de Loubens Faïçal Nait Bouda Sofiane Hamani Dynamics of a Gel-Based Artificial Tear Film with an Emphasis on Dry Disease Treatment Applications Gels dry eye disease gel-based artificial tears Herschel–Bulkley model tear film breakup VOF method |
| title | Dynamics of a Gel-Based Artificial Tear Film with an Emphasis on Dry Disease Treatment Applications |
| title_full | Dynamics of a Gel-Based Artificial Tear Film with an Emphasis on Dry Disease Treatment Applications |
| title_fullStr | Dynamics of a Gel-Based Artificial Tear Film with an Emphasis on Dry Disease Treatment Applications |
| title_full_unstemmed | Dynamics of a Gel-Based Artificial Tear Film with an Emphasis on Dry Disease Treatment Applications |
| title_short | Dynamics of a Gel-Based Artificial Tear Film with an Emphasis on Dry Disease Treatment Applications |
| title_sort | dynamics of a gel based artificial tear film with an emphasis on dry disease treatment applications |
| topic | dry eye disease gel-based artificial tears Herschel–Bulkley model tear film breakup VOF method |
| url | https://www.mdpi.com/2310-2861/7/4/215 |
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