Transcriptomic changes in mouse embryonic stem cells exposed to thalidomide during spontaneous differentiation
Thalidomide is a potent developmental toxicant that induces a range of birth defects, notably severe limb malformations. To unravel the molecular mechanisms underpinning the teratogenic effects of thalidomide, we used microarrays to study transcriptomic changes induced by thalidomide in an in vitro...
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| Format: | Article |
| Language: | English |
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Elsevier
2015-09-01
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| Series: | Data in Brief |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352340915000827 |
| _version_ | 1818955941488361472 |
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| author | Xiugong Gao Robert L. Sprando Jeffrey J. Yourick |
| author_facet | Xiugong Gao Robert L. Sprando Jeffrey J. Yourick |
| author_sort | Xiugong Gao |
| collection | DOAJ |
| description | Thalidomide is a potent developmental toxicant that induces a range of birth defects, notably severe limb malformations. To unravel the molecular mechanisms underpinning the teratogenic effects of thalidomide, we used microarrays to study transcriptomic changes induced by thalidomide in an in vitro model based on the differentiation of mouse embryonic stem cells (mESCs), and published the major findings in a research article entitled “Thalidomide induced early gene expression perturbations indicative of human embryopathy in mouse embryonic stem cells” [1]. The data presented herein contains complementary information related to the aforementioned research article. |
| first_indexed | 2024-12-20T10:46:04Z |
| format | Article |
| id | doaj.art-a5223b42d0b349e5ba295d7447ecea67 |
| institution | Directory Open Access Journal |
| issn | 2352-3409 |
| language | English |
| last_indexed | 2024-12-20T10:46:04Z |
| publishDate | 2015-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Data in Brief |
| spelling | doaj.art-a5223b42d0b349e5ba295d7447ecea672022-12-21T19:43:25ZengElsevierData in Brief2352-34092015-09-014C19920210.1016/j.dib.2015.05.014Transcriptomic changes in mouse embryonic stem cells exposed to thalidomide during spontaneous differentiationXiugong GaoRobert L. SprandoJeffrey J. YourickThalidomide is a potent developmental toxicant that induces a range of birth defects, notably severe limb malformations. To unravel the molecular mechanisms underpinning the teratogenic effects of thalidomide, we used microarrays to study transcriptomic changes induced by thalidomide in an in vitro model based on the differentiation of mouse embryonic stem cells (mESCs), and published the major findings in a research article entitled “Thalidomide induced early gene expression perturbations indicative of human embryopathy in mouse embryonic stem cells” [1]. The data presented herein contains complementary information related to the aforementioned research article.http://www.sciencedirect.com/science/article/pii/S2352340915000827ThalidomideTranscriptomicsEmbryonic stem cellDevelopmental toxicityDifferentiationMicroarrayMouse |
| spellingShingle | Xiugong Gao Robert L. Sprando Jeffrey J. Yourick Transcriptomic changes in mouse embryonic stem cells exposed to thalidomide during spontaneous differentiation Data in Brief Thalidomide Transcriptomics Embryonic stem cell Developmental toxicity Differentiation Microarray Mouse |
| title | Transcriptomic changes in mouse embryonic stem cells exposed to thalidomide during spontaneous differentiation |
| title_full | Transcriptomic changes in mouse embryonic stem cells exposed to thalidomide during spontaneous differentiation |
| title_fullStr | Transcriptomic changes in mouse embryonic stem cells exposed to thalidomide during spontaneous differentiation |
| title_full_unstemmed | Transcriptomic changes in mouse embryonic stem cells exposed to thalidomide during spontaneous differentiation |
| title_short | Transcriptomic changes in mouse embryonic stem cells exposed to thalidomide during spontaneous differentiation |
| title_sort | transcriptomic changes in mouse embryonic stem cells exposed to thalidomide during spontaneous differentiation |
| topic | Thalidomide Transcriptomics Embryonic stem cell Developmental toxicity Differentiation Microarray Mouse |
| url | http://www.sciencedirect.com/science/article/pii/S2352340915000827 |
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