484 A Preliminary Study on the Pharmacodynamics of Oral Cannabis Ingestion in Older Adults
OBJECTIVES/GOALS: Our study explores the dose-related effects of THC on cardiovascular measures, self-reported effects, balance, and cognitive function among older adults. We also evaluate the acceptability and feasibility of study procedures, to inform future study designs employing this population...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Cambridge University Press
2024-04-01
|
| Series: | Journal of Clinical and Translational Science |
| Online Access: | https://www.cambridge.org/core/product/identifier/S2059866124004102/type/journal_article |
| _version_ | 1797226845512400896 |
|---|---|
| author | Lauren Russell Merideth Addicott Priya Mendiratta Jeff Thostenson Srinivasa Gokarakonda Laura Dunn Michael Wilson Michael Mancino Alison Oliveto |
| author_facet | Lauren Russell Merideth Addicott Priya Mendiratta Jeff Thostenson Srinivasa Gokarakonda Laura Dunn Michael Wilson Michael Mancino Alison Oliveto |
| author_sort | Lauren Russell |
| collection | DOAJ |
| description | OBJECTIVES/GOALS: Our study explores the dose-related effects of THC on cardiovascular measures, self-reported effects, balance, and cognitive function among older adults. We also evaluate the acceptability and feasibility of study procedures, to inform future study designs employing this population. METHODS/STUDY POPULATION: Using a within-subject, double-blind, placebo-controlled design and standard behavioral pharmacology methods, reasonably healthy male and female adults aged 55-70 years undergo an eligibility screening, followed by a mock session and 3 experimental sessions (>7 days apart). During experimental sessions, participants are administered cannabis-infused brownies with varying THC doses. Prior to and at multiple intervals post- consumption, subjects complete assessments including self reports and observer ratings, psychomotor and cognitive performance measures, and vital signs. Follow-up interviews regarding the experience will be conducted one day after each session. RESULTS/ANTICIPATED RESULTS: We anticipate our results to mirror those of previously reported studies conducted in adults under 45 years old in that a dose-response relationship exists for subjective drug effects and vital signs with the caveat that this relationship may be exacerbated in our population. We additionally anticipate findings that indicate THC impairs balance and coordination, potentially increasing the risk of falls and accidents among this population, and cognitive function, affecting attention, memory, and executive functions. Feedback provided during the follow-up interviews will help refine procedures for future studies, ensuring that the methodology is acceptable and feasible for this population. DISCUSSION/SIGNIFICANCE: Prior work demonstrates the safety and efficacy of THC in conditions common among older adults, however, no conclusive data regarding tolerability and safety in this population exists. The presented work is vital groundwork for future research on THC as a potential therapeutic for older adults. |
| first_indexed | 2024-04-24T14:31:23Z |
| format | Article |
| id | doaj.art-a522f5c3d8be457c92149f9fb5eb8829 |
| institution | Directory Open Access Journal |
| issn | 2059-8661 |
| language | English |
| last_indexed | 2024-04-24T14:31:23Z |
| publishDate | 2024-04-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | Journal of Clinical and Translational Science |
| spelling | doaj.art-a522f5c3d8be457c92149f9fb5eb88292024-04-03T02:00:35ZengCambridge University PressJournal of Clinical and Translational Science2059-86612024-04-01814314310.1017/cts.2024.410484 A Preliminary Study on the Pharmacodynamics of Oral Cannabis Ingestion in Older AdultsLauren Russell0Merideth Addicott1Priya Mendiratta2Jeff Thostenson3Srinivasa Gokarakonda4Laura Dunn5Michael Wilson6Michael Mancino7Alison Oliveto8University of Arkansas for Medical SciencesWake ForestUniversity of Arkansas for Medical SciencesUniversity of Arkansas for Medical SciencesUniversity of Arkansas for Medical SciencesUniversity of Arkansas for Medical SciencesUniversity of Arkansas for Medical SciencesUniversity of Arkansas for Medical SciencesUniversity of Arkansas for Medical SciencesOBJECTIVES/GOALS: Our study explores the dose-related effects of THC on cardiovascular measures, self-reported effects, balance, and cognitive function among older adults. We also evaluate the acceptability and feasibility of study procedures, to inform future study designs employing this population. METHODS/STUDY POPULATION: Using a within-subject, double-blind, placebo-controlled design and standard behavioral pharmacology methods, reasonably healthy male and female adults aged 55-70 years undergo an eligibility screening, followed by a mock session and 3 experimental sessions (>7 days apart). During experimental sessions, participants are administered cannabis-infused brownies with varying THC doses. Prior to and at multiple intervals post- consumption, subjects complete assessments including self reports and observer ratings, psychomotor and cognitive performance measures, and vital signs. Follow-up interviews regarding the experience will be conducted one day after each session. RESULTS/ANTICIPATED RESULTS: We anticipate our results to mirror those of previously reported studies conducted in adults under 45 years old in that a dose-response relationship exists for subjective drug effects and vital signs with the caveat that this relationship may be exacerbated in our population. We additionally anticipate findings that indicate THC impairs balance and coordination, potentially increasing the risk of falls and accidents among this population, and cognitive function, affecting attention, memory, and executive functions. Feedback provided during the follow-up interviews will help refine procedures for future studies, ensuring that the methodology is acceptable and feasible for this population. DISCUSSION/SIGNIFICANCE: Prior work demonstrates the safety and efficacy of THC in conditions common among older adults, however, no conclusive data regarding tolerability and safety in this population exists. The presented work is vital groundwork for future research on THC as a potential therapeutic for older adults.https://www.cambridge.org/core/product/identifier/S2059866124004102/type/journal_article |
| spellingShingle | Lauren Russell Merideth Addicott Priya Mendiratta Jeff Thostenson Srinivasa Gokarakonda Laura Dunn Michael Wilson Michael Mancino Alison Oliveto 484 A Preliminary Study on the Pharmacodynamics of Oral Cannabis Ingestion in Older Adults Journal of Clinical and Translational Science |
| title | 484 A Preliminary Study on the Pharmacodynamics of Oral Cannabis Ingestion in Older Adults |
| title_full | 484 A Preliminary Study on the Pharmacodynamics of Oral Cannabis Ingestion in Older Adults |
| title_fullStr | 484 A Preliminary Study on the Pharmacodynamics of Oral Cannabis Ingestion in Older Adults |
| title_full_unstemmed | 484 A Preliminary Study on the Pharmacodynamics of Oral Cannabis Ingestion in Older Adults |
| title_short | 484 A Preliminary Study on the Pharmacodynamics of Oral Cannabis Ingestion in Older Adults |
| title_sort | 484 a preliminary study on the pharmacodynamics of oral cannabis ingestion in older adults |
| url | https://www.cambridge.org/core/product/identifier/S2059866124004102/type/journal_article |
| work_keys_str_mv | AT laurenrussell 484apreliminarystudyonthepharmacodynamicsoforalcannabisingestioninolderadults AT meridethaddicott 484apreliminarystudyonthepharmacodynamicsoforalcannabisingestioninolderadults AT priyamendiratta 484apreliminarystudyonthepharmacodynamicsoforalcannabisingestioninolderadults AT jeffthostenson 484apreliminarystudyonthepharmacodynamicsoforalcannabisingestioninolderadults AT srinivasagokarakonda 484apreliminarystudyonthepharmacodynamicsoforalcannabisingestioninolderadults AT lauradunn 484apreliminarystudyonthepharmacodynamicsoforalcannabisingestioninolderadults AT michaelwilson 484apreliminarystudyonthepharmacodynamicsoforalcannabisingestioninolderadults AT michaelmancino 484apreliminarystudyonthepharmacodynamicsoforalcannabisingestioninolderadults AT alisonoliveto 484apreliminarystudyonthepharmacodynamicsoforalcannabisingestioninolderadults |