Objective preclinical measures for bone conduction implants
The study evaluates the accuracy of predicting intracochlear pressure during bone conduction stimulation using promontory velocity and ear canal pressure, as less invasive alternatives to intracochlear pressure. Stimulating with a percutaneous bone conduction device implanted in six human cadaveric...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-03-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2024.1324971/full |
| _version_ | 1797263076374872064 |
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| author | Irina Wils Alexander Geerardyn Alexander Geerardyn Tristan Putzeys Tristan Putzeys Guy Fierens Guy Fierens Guy Fierens Kathleen Denis Nicolas Verhaert Nicolas Verhaert |
| author_facet | Irina Wils Alexander Geerardyn Alexander Geerardyn Tristan Putzeys Tristan Putzeys Guy Fierens Guy Fierens Guy Fierens Kathleen Denis Nicolas Verhaert Nicolas Verhaert |
| author_sort | Irina Wils |
| collection | DOAJ |
| description | The study evaluates the accuracy of predicting intracochlear pressure during bone conduction stimulation using promontory velocity and ear canal pressure, as less invasive alternatives to intracochlear pressure. Stimulating with a percutaneous bone conduction device implanted in six human cadaveric ears, measurements were taken across various intensities, frequencies, and stimulation positions. Results indicate that intracochlear pressure linearly correlates with ear canal pressure (R2 = 0.43, RMSE = 6.85 dB), and promontory velocity (R2 = 0.47, RMSE = 6.60 dB). Normalizing data to mitigate the influence of stimulation position leads to a substantial improvement in these correlations. R2 values increased substantially to 0.93 for both the ear canal pressure and the promontory velocity, with RMSE reduced considerably to 2.02 (for ear canal pressure) and 1.94 dB (for promontory velocity). Conclusively, both ear canal pressure and promontory velocity showed potential in predicting intracochlear pressure and the prediction accuracy notably enhanced when accounting for stimulation position. Ultimately, these findings advocate for the continued use of intracochlear pressure measurements to evaluate future bone conduction devices and illuminate the role of stimulation position in influencing the dynamics of bone conduction pathways. |
| first_indexed | 2024-04-25T00:07:15Z |
| format | Article |
| id | doaj.art-a52494597d434a45b1a3265f829e138a |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-04-25T00:07:15Z |
| publishDate | 2024-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-a52494597d434a45b1a3265f829e138a2024-03-14T04:30:21ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2024-03-011810.3389/fnins.2024.13249711324971Objective preclinical measures for bone conduction implantsIrina Wils0Alexander Geerardyn1Alexander Geerardyn2Tristan Putzeys3Tristan Putzeys4Guy Fierens5Guy Fierens6Guy Fierens7Kathleen Denis8Nicolas Verhaert9Nicolas Verhaert10Department of Neurosciences, Experimental Otorhinolaryngology, KU Leuven, Leuven, BelgiumDepartment of Neurosciences, Experimental Otorhinolaryngology, KU Leuven, Leuven, BelgiumDepartment of Otorhinolaryngology, Head and Neck Surgery, University Hospitals Leuven, Leuven, BelgiumDepartment of Neurosciences, Experimental Otorhinolaryngology, KU Leuven, Leuven, BelgiumLaboratory for Soft Matter and Biophysics, Department of Physics and Astronomy, KU Leuven, Leuven, BelgiumDepartment of Neurosciences, Experimental Otorhinolaryngology, KU Leuven, Leuven, BelgiumLaboratory for Soft Matter and Biophysics, Department of Physics and Astronomy, KU Leuven, Leuven, BelgiumCochlear Technology Centre Belgium, Mechelen, BelgiumBiomechanics Section, Department of Mechanical Engineering, KU Leuven, Leuven, BelgiumDepartment of Neurosciences, Experimental Otorhinolaryngology, KU Leuven, Leuven, BelgiumDepartment of Otorhinolaryngology, Head and Neck Surgery, University Hospitals Leuven, Leuven, BelgiumThe study evaluates the accuracy of predicting intracochlear pressure during bone conduction stimulation using promontory velocity and ear canal pressure, as less invasive alternatives to intracochlear pressure. Stimulating with a percutaneous bone conduction device implanted in six human cadaveric ears, measurements were taken across various intensities, frequencies, and stimulation positions. Results indicate that intracochlear pressure linearly correlates with ear canal pressure (R2 = 0.43, RMSE = 6.85 dB), and promontory velocity (R2 = 0.47, RMSE = 6.60 dB). Normalizing data to mitigate the influence of stimulation position leads to a substantial improvement in these correlations. R2 values increased substantially to 0.93 for both the ear canal pressure and the promontory velocity, with RMSE reduced considerably to 2.02 (for ear canal pressure) and 1.94 dB (for promontory velocity). Conclusively, both ear canal pressure and promontory velocity showed potential in predicting intracochlear pressure and the prediction accuracy notably enhanced when accounting for stimulation position. Ultimately, these findings advocate for the continued use of intracochlear pressure measurements to evaluate future bone conduction devices and illuminate the role of stimulation position in influencing the dynamics of bone conduction pathways.https://www.frontiersin.org/articles/10.3389/fnins.2024.1324971/fullbone conductionintracochlear pressurepromontory velocityear canal pressureobjective measures |
| spellingShingle | Irina Wils Alexander Geerardyn Alexander Geerardyn Tristan Putzeys Tristan Putzeys Guy Fierens Guy Fierens Guy Fierens Kathleen Denis Nicolas Verhaert Nicolas Verhaert Objective preclinical measures for bone conduction implants Frontiers in Neuroscience bone conduction intracochlear pressure promontory velocity ear canal pressure objective measures |
| title | Objective preclinical measures for bone conduction implants |
| title_full | Objective preclinical measures for bone conduction implants |
| title_fullStr | Objective preclinical measures for bone conduction implants |
| title_full_unstemmed | Objective preclinical measures for bone conduction implants |
| title_short | Objective preclinical measures for bone conduction implants |
| title_sort | objective preclinical measures for bone conduction implants |
| topic | bone conduction intracochlear pressure promontory velocity ear canal pressure objective measures |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2024.1324971/full |
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