Curcumin AntiCancer Studies in Pancreatic Cancer
Pancreatic cancer (PC) is one of the deadliest cancers worldwide. Surgical resection remains the only curative therapeutic treatment for this disease, although only the minority of patients can be resected due to late diagnosis. Systemic gemcitabine-based chemotherapy plus nab-paclitaxel are used as...
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| Format: | Article |
| Language: | English |
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MDPI AG
2016-07-01
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| Series: | Nutrients |
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| Online Access: | http://www.mdpi.com/2072-6643/8/7/433 |
| _version_ | 1811314811104919552 |
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| author | Sabrina Bimonte Antonio Barbieri Maddalena Leongito Mauro Piccirillo Aldo Giudice Claudia Pivonello Cristina de Angelis Vincenza Granata Raffaele Palaia Francesco Izzo |
| author_facet | Sabrina Bimonte Antonio Barbieri Maddalena Leongito Mauro Piccirillo Aldo Giudice Claudia Pivonello Cristina de Angelis Vincenza Granata Raffaele Palaia Francesco Izzo |
| author_sort | Sabrina Bimonte |
| collection | DOAJ |
| description | Pancreatic cancer (PC) is one of the deadliest cancers worldwide. Surgical resection remains the only curative therapeutic treatment for this disease, although only the minority of patients can be resected due to late diagnosis. Systemic gemcitabine-based chemotherapy plus nab-paclitaxel are used as the gold-standard therapy for patients with advanced PC; although this treatment is associated with a better overall survival compared to the old treatment, many side effects and poor results are still present. Therefore, new alternative therapies have been considered for treatment of advanced PC. Several preclinical studies have demonstrated that curcumin, a naturally occurring polyphenolic compound, has anticancer effects against different types of cancer, including PC, by modulating many molecular targets. Regarding PC, in vitro studies have shown potent cytotoxic effects of curcumin on different PC cell lines including MiaPaCa-2, Panc-1, AsPC-1, and BxPC-3. In addition, in vivo studies on PC models have shown that the anti-proliferative effects of curcumin are caused by the inhibition of oxidative stress and angiogenesis and are due to the induction of apoptosis. On the basis of these results, several researchers tested the anticancer effects of curcumin in clinical trials, trying to overcome the poor bioavailability of this agent by developing new bioavailable forms of curcumin. In this article, we review the results of pre-clinical and clinical studies on the effects of curcumin in the treatment of PC. |
| first_indexed | 2024-04-13T11:17:52Z |
| format | Article |
| id | doaj.art-a52571b9f94f490591540dfa9df7373c |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-04-13T11:17:52Z |
| publishDate | 2016-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-a52571b9f94f490591540dfa9df7373c2022-12-22T02:48:54ZengMDPI AGNutrients2072-66432016-07-018743310.3390/nu8070433nu8070433Curcumin AntiCancer Studies in Pancreatic CancerSabrina Bimonte0Antonio Barbieri1Maddalena Leongito2Mauro Piccirillo3Aldo Giudice4Claudia Pivonello5Cristina de Angelis6Vincenza Granata7Raffaele Palaia8Francesco Izzo9Division of Abdominal Surgical Oncology, Hepatobiliary Unit, Istituto Nazionale per lo studio e la cura dei Tumori “Fondazione G. Pascale”—IRCCS—Via Mariano Semmola, Naples 80131, ItalyS.S.D Sperimentazione Animale, Istituto Nazionale per lo studio e la cura dei Tumori “Fondazione G. Pascale”—IRCCS, Naples 80131, ItalyDivision of Abdominal Surgical Oncology, Hepatobiliary Unit, Istituto Nazionale per lo studio e la cura dei Tumori “Fondazione G. Pascale”—IRCCS—Via Mariano Semmola, Naples 80131, ItalyDivision of Abdominal Surgical Oncology, Hepatobiliary Unit, Istituto Nazionale per lo studio e la cura dei Tumori “Fondazione G. Pascale”—IRCCS—Via Mariano Semmola, Naples 80131, ItalyEpidemiology Unit, Istituto Nazionale per lo studio e la cura dei Tumori “Fondazione G. Pascale”—IRCCS—Via Mariano Semmola, Naples 80131, ItalyDipartimento di Medicina Clinica e Chirurgia, Sezione di Endocrinologia, Università di Napoli Federico II, Naples 80131, ItalyI.O.S. & Coleman Srl, Naples 80011, ItalyDivision of Radiology, Istituto Nazionale per lo studio e la cura dei Tumori “Fondazione G. Pascale”—IRCCS—Via Mariano Semmola, Naples 80131, ItalyDivision of Abdominal Surgical Oncology, Hepatobiliary Unit, Istituto Nazionale per lo studio e la cura dei Tumori “Fondazione G. Pascale”—IRCCS—Via Mariano Semmola, Naples 80131, ItalyDivision of Abdominal Surgical Oncology, Hepatobiliary Unit, Istituto Nazionale per lo studio e la cura dei Tumori “Fondazione G. Pascale”—IRCCS—Via Mariano Semmola, Naples 80131, ItalyPancreatic cancer (PC) is one of the deadliest cancers worldwide. Surgical resection remains the only curative therapeutic treatment for this disease, although only the minority of patients can be resected due to late diagnosis. Systemic gemcitabine-based chemotherapy plus nab-paclitaxel are used as the gold-standard therapy for patients with advanced PC; although this treatment is associated with a better overall survival compared to the old treatment, many side effects and poor results are still present. Therefore, new alternative therapies have been considered for treatment of advanced PC. Several preclinical studies have demonstrated that curcumin, a naturally occurring polyphenolic compound, has anticancer effects against different types of cancer, including PC, by modulating many molecular targets. Regarding PC, in vitro studies have shown potent cytotoxic effects of curcumin on different PC cell lines including MiaPaCa-2, Panc-1, AsPC-1, and BxPC-3. In addition, in vivo studies on PC models have shown that the anti-proliferative effects of curcumin are caused by the inhibition of oxidative stress and angiogenesis and are due to the induction of apoptosis. On the basis of these results, several researchers tested the anticancer effects of curcumin in clinical trials, trying to overcome the poor bioavailability of this agent by developing new bioavailable forms of curcumin. In this article, we review the results of pre-clinical and clinical studies on the effects of curcumin in the treatment of PC.http://www.mdpi.com/2072-6643/8/7/433curcuminnatural compoundpancreatic cancertherapy |
| spellingShingle | Sabrina Bimonte Antonio Barbieri Maddalena Leongito Mauro Piccirillo Aldo Giudice Claudia Pivonello Cristina de Angelis Vincenza Granata Raffaele Palaia Francesco Izzo Curcumin AntiCancer Studies in Pancreatic Cancer Nutrients curcumin natural compound pancreatic cancer therapy |
| title | Curcumin AntiCancer Studies in Pancreatic Cancer |
| title_full | Curcumin AntiCancer Studies in Pancreatic Cancer |
| title_fullStr | Curcumin AntiCancer Studies in Pancreatic Cancer |
| title_full_unstemmed | Curcumin AntiCancer Studies in Pancreatic Cancer |
| title_short | Curcumin AntiCancer Studies in Pancreatic Cancer |
| title_sort | curcumin anticancer studies in pancreatic cancer |
| topic | curcumin natural compound pancreatic cancer therapy |
| url | http://www.mdpi.com/2072-6643/8/7/433 |
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