Reduced Dynamic Interactions Within Intrinsic Functional Brain Networks in Early Blind Patients
Neuroimaging studies in early blind (EB) patients have shown altered connections or brain networks. However, it remains unclear how the causal relationships are disrupted within intrinsic brain networks. In our study, we used spectral dynamic causal modeling (DCM) to estimate the causal interactions...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-03-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fnins.2019.00268/full |
| _version_ | 1818837756880617472 |
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| author | Xianglin Li Xianglin Li Ailing Wang Junhai Xu Zhenbo Sun Jikai Xia Peiyuan Wang Bin Wang Ming Zhang Jie Tian Jie Tian |
| author_facet | Xianglin Li Xianglin Li Ailing Wang Junhai Xu Zhenbo Sun Jikai Xia Peiyuan Wang Bin Wang Ming Zhang Jie Tian Jie Tian |
| author_sort | Xianglin Li |
| collection | DOAJ |
| description | Neuroimaging studies in early blind (EB) patients have shown altered connections or brain networks. However, it remains unclear how the causal relationships are disrupted within intrinsic brain networks. In our study, we used spectral dynamic causal modeling (DCM) to estimate the causal interactions using resting-state data in a group of 20 EB patients and 20 healthy controls (HC). Coupling parameters in specific regions were estimated, including the medial prefrontal cortex (mPFC), posterior cingulate cortex (PCC), and inferior parietal lobule (IPC) in the default mode network (DMN); dorsal anterior cingulate cortex (dACC) and bilateral anterior insulae (AI) in the salience network (SN), and bilateral frontal eye fields (FEF) and superior parietal lobes (SPL) within the dorsal attention network (DAN). Statistical analyses found that all endogenous connections and the connections from the mPFC to bilateral IPCs in EB patients were significantly reduced within the DMN, and the effective connectivity from the PCC and lIPC to the mPFC, and from the mPFC to the PCC were enhanced. For the SN, all significant connections in EB patients were significantly decreased, except the intrinsic right AI connections. Within the DAN, more significant effective connections were observed to be reduced between the EB and HC groups, while only the connections from the right SPL to the left SPL and the intrinsic connection in the left SPL were significantly enhanced. Furthermore, discovery of more decreased effective connections in the EB subjects suggested that the disrupted causal interactions between specific regions are responsive to the compensatory brain plasticity in early deprivation. |
| first_indexed | 2024-12-19T03:27:34Z |
| format | Article |
| id | doaj.art-a527851a37634ef3abed7cf7ca499fe1 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-12-19T03:27:34Z |
| publishDate | 2019-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-a527851a37634ef3abed7cf7ca499fe12022-12-21T20:37:34ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2019-03-011310.3389/fnins.2019.00268445631Reduced Dynamic Interactions Within Intrinsic Functional Brain Networks in Early Blind PatientsXianglin Li0Xianglin Li1Ailing Wang2Junhai Xu3Zhenbo Sun4Jikai Xia5Peiyuan Wang6Bin Wang7Ming Zhang8Jie Tian9Jie Tian10Department of Medical Imaging, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaMedical Imaging Research Institute, Binzhou Medical University, Yantai, ChinaDepartment of Clinical Laboratory, Yantai Affiliated Hospital of Binzhou Medical University, Yantai, ChinaTianjin Key Laboratory of Cognitive Computing and Application, School of Artificial Intelligence, College of Intelligence and Computing, Tianjin University, Tianjin, ChinaMedical Imaging Research Institute, Binzhou Medical University, Yantai, ChinaDepartment of Radiology, Yantai Affiliated Hospital of Binzhou Medical University, Yantai, ChinaDepartment of Radiology, Yantai Affiliated Hospital of Binzhou Medical University, Yantai, ChinaMedical Imaging Research Institute, Binzhou Medical University, Yantai, ChinaDepartment of Medical Imaging, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaDepartment of Medical Imaging, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaSchool of Life Sciences and Technology, Xidian University, Xi’an, ChinaNeuroimaging studies in early blind (EB) patients have shown altered connections or brain networks. However, it remains unclear how the causal relationships are disrupted within intrinsic brain networks. In our study, we used spectral dynamic causal modeling (DCM) to estimate the causal interactions using resting-state data in a group of 20 EB patients and 20 healthy controls (HC). Coupling parameters in specific regions were estimated, including the medial prefrontal cortex (mPFC), posterior cingulate cortex (PCC), and inferior parietal lobule (IPC) in the default mode network (DMN); dorsal anterior cingulate cortex (dACC) and bilateral anterior insulae (AI) in the salience network (SN), and bilateral frontal eye fields (FEF) and superior parietal lobes (SPL) within the dorsal attention network (DAN). Statistical analyses found that all endogenous connections and the connections from the mPFC to bilateral IPCs in EB patients were significantly reduced within the DMN, and the effective connectivity from the PCC and lIPC to the mPFC, and from the mPFC to the PCC were enhanced. For the SN, all significant connections in EB patients were significantly decreased, except the intrinsic right AI connections. Within the DAN, more significant effective connections were observed to be reduced between the EB and HC groups, while only the connections from the right SPL to the left SPL and the intrinsic connection in the left SPL were significantly enhanced. Furthermore, discovery of more decreased effective connections in the EB subjects suggested that the disrupted causal interactions between specific regions are responsive to the compensatory brain plasticity in early deprivation.https://www.frontiersin.org/article/10.3389/fnins.2019.00268/fullearly blindnesseffective connectivityspectral dynamic causal modelingintrinsic brain networksbrain plasticity |
| spellingShingle | Xianglin Li Xianglin Li Ailing Wang Junhai Xu Zhenbo Sun Jikai Xia Peiyuan Wang Bin Wang Ming Zhang Jie Tian Jie Tian Reduced Dynamic Interactions Within Intrinsic Functional Brain Networks in Early Blind Patients Frontiers in Neuroscience early blindness effective connectivity spectral dynamic causal modeling intrinsic brain networks brain plasticity |
| title | Reduced Dynamic Interactions Within Intrinsic Functional Brain Networks in Early Blind Patients |
| title_full | Reduced Dynamic Interactions Within Intrinsic Functional Brain Networks in Early Blind Patients |
| title_fullStr | Reduced Dynamic Interactions Within Intrinsic Functional Brain Networks in Early Blind Patients |
| title_full_unstemmed | Reduced Dynamic Interactions Within Intrinsic Functional Brain Networks in Early Blind Patients |
| title_short | Reduced Dynamic Interactions Within Intrinsic Functional Brain Networks in Early Blind Patients |
| title_sort | reduced dynamic interactions within intrinsic functional brain networks in early blind patients |
| topic | early blindness effective connectivity spectral dynamic causal modeling intrinsic brain networks brain plasticity |
| url | https://www.frontiersin.org/article/10.3389/fnins.2019.00268/full |
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