Myeloproliferative neoplasm-driving Calr frameshift promotes the development of pulmonary hypertension in mice

Myeloproliferative neoplasm-driving Calr frameshift promotes the development of pulmonary hypertension in mice

Abstract Frameshifts in the Calreticulin (CALR) exon 9 provide a recurrent driver mutation of essential thrombocythemia (ET) and primary myelofibrosis among myeloproliferative neoplasms (MPNs). Here, we generated knock-in mice with murine Calr exon 9 mimicking the human CALR mutations, using the CRI...

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Bibliographic Details
Main Authors: Keiji Minakawa, Tetsuro Yokokawa, Koki Ueda, Osamu Nakajima, Tomofumi Misaka, Yusuke Kimishima, Kento Wada, Yusuke Tomita, Saori Miura, Yuka Sato, Kosaku Mimura, Koichi Sugimoto, Kazuhiko Nakazato, Kenneth E. Nollet, Kazuei Ogawa, Takayuki Ikezoe, Yuko Hashimoto, Yasuchika Takeishi, Kazuhiko Ikeda
Format: Article
Language:English
Published: BMC 2021-03-01
Series:Journal of Hematology & Oncology
Subjects:
CALR
Pulmonary hypertension
Myeloproliferative neoplasms
Macrophage
Essential thrombocythemia
Online Access:https://doi.org/10.1186/s13045-021-01064-8

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