Introducing NMR strategies to define water molecules that drive metal binding in a transcriptional regulator
Staphylococcus aureus CzrA is a paradigmatic member of the ArsR family of transcriptional metalloregulators, which are critical for the bacterial response to stress. Zinc binding to CzrA, which induces DNA derepression, is entropically driven, as shown by calorimetry. A detailed equilibrium dynamics...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-12-01
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| Series: | Journal of Magnetic Resonance Open |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666441023000225 |