Challenges of SARS-CoV-2 Omicron Variant and appropriate countermeasures
The Omicron (B.1.1.529) variant was first reported in South Africa and rapidly spread worldwide in early November 2021. This caused panic in various countries, so it is necessary to understand Omicron Variant. This paper summarizes omicron variant-related research achievements. Studies have shown th...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-06-01
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| Series: | Journal of Microbiology, Immunology and Infection |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1684118222000548 |
| _version_ | 1828328117359345664 |
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| author | Wenxia Shao Weiying Zhang Xiang Fang Daojun Yu Xianjun Wang |
| author_facet | Wenxia Shao Weiying Zhang Xiang Fang Daojun Yu Xianjun Wang |
| author_sort | Wenxia Shao |
| collection | DOAJ |
| description | The Omicron (B.1.1.529) variant was first reported in South Africa and rapidly spread worldwide in early November 2021. This caused panic in various countries, so it is necessary to understand Omicron Variant. This paper summarizes omicron variant-related research achievements. Studies have shown that Omicron Variant contains many mutations that make it more infectious and transmissible. At the same time, immune escape is also caused, resulting in reduced efficacy of existing vaccines, increased risk of reinfection, treatment failure or reduction of monoclonal antibody therapies, and detection failure. However, current data indicate that Omicron Variant causes mild clinical symptoms and few severe cases and deaths. Omicron Variant is valid for a range of nonpharmaceutical interventions against SARS-CoV-2. Improving diagnostic accuracy and enabling timely isolation and treatment of diagnosed cases is also critical to interrupting the spread of omicron variants. COVID-19 vaccine boosters could undoubtedly help control Omicron spread and infection. However, developing a vaccine specific to Omicron Variant is also imminent. |
| first_indexed | 2024-04-13T20:04:20Z |
| format | Article |
| id | doaj.art-a52e9a96323245c9bc660aba086f4a5c |
| institution | Directory Open Access Journal |
| issn | 1684-1182 |
| language | English |
| last_indexed | 2024-04-13T20:04:20Z |
| publishDate | 2022-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Microbiology, Immunology and Infection |
| spelling | doaj.art-a52e9a96323245c9bc660aba086f4a5c2022-12-22T02:32:04ZengElsevierJournal of Microbiology, Immunology and Infection1684-11822022-06-01553387394Challenges of SARS-CoV-2 Omicron Variant and appropriate countermeasuresWenxia Shao0Weiying Zhang1Xiang Fang2Daojun Yu3Xianjun Wang4Department of Laboratory Medicine, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Laboratory Medicine, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Laboratory Medicine, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaCorresponding author.; Department of Laboratory Medicine, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaCorresponding author. Department of Laboratory Medicine, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, No.261, Huansha Road, Hangzhou, PR China.; Department of Laboratory Medicine, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaThe Omicron (B.1.1.529) variant was first reported in South Africa and rapidly spread worldwide in early November 2021. This caused panic in various countries, so it is necessary to understand Omicron Variant. This paper summarizes omicron variant-related research achievements. Studies have shown that Omicron Variant contains many mutations that make it more infectious and transmissible. At the same time, immune escape is also caused, resulting in reduced efficacy of existing vaccines, increased risk of reinfection, treatment failure or reduction of monoclonal antibody therapies, and detection failure. However, current data indicate that Omicron Variant causes mild clinical symptoms and few severe cases and deaths. Omicron Variant is valid for a range of nonpharmaceutical interventions against SARS-CoV-2. Improving diagnostic accuracy and enabling timely isolation and treatment of diagnosed cases is also critical to interrupting the spread of omicron variants. COVID-19 vaccine boosters could undoubtedly help control Omicron spread and infection. However, developing a vaccine specific to Omicron Variant is also imminent.http://www.sciencedirect.com/science/article/pii/S1684118222000548SARS-CoV-2COVID-19Omicron variantsB.1.1.529Immune escape |
| spellingShingle | Wenxia Shao Weiying Zhang Xiang Fang Daojun Yu Xianjun Wang Challenges of SARS-CoV-2 Omicron Variant and appropriate countermeasures Journal of Microbiology, Immunology and Infection SARS-CoV-2 COVID-19 Omicron variants B.1.1.529 Immune escape |
| title | Challenges of SARS-CoV-2 Omicron Variant and appropriate countermeasures |
| title_full | Challenges of SARS-CoV-2 Omicron Variant and appropriate countermeasures |
| title_fullStr | Challenges of SARS-CoV-2 Omicron Variant and appropriate countermeasures |
| title_full_unstemmed | Challenges of SARS-CoV-2 Omicron Variant and appropriate countermeasures |
| title_short | Challenges of SARS-CoV-2 Omicron Variant and appropriate countermeasures |
| title_sort | challenges of sars cov 2 omicron variant and appropriate countermeasures |
| topic | SARS-CoV-2 COVID-19 Omicron variants B.1.1.529 Immune escape |
| url | http://www.sciencedirect.com/science/article/pii/S1684118222000548 |
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