Research advances in endometriosis-related signaling pathways: A review
Endometriosis (EM) is characterized by the existence of endometrial mucosa outside the uterine cavity, which causesinfertility, persistent aches, and a decline in women's quality of life. Both hormone therapies and nonhormone therapies, such as NSAIDs, are ineffective, generic categories of EM...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-08-01
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| Series: | Biomedicine & Pharmacotherapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332223006996 |
| _version_ | 1797801859184852992 |
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| author | Manlin Zhang Tongtong Xu Deming Tong Siman Li Xiaodan Yu Boya Liu Lili Jiang Kuiran Liu |
| author_facet | Manlin Zhang Tongtong Xu Deming Tong Siman Li Xiaodan Yu Boya Liu Lili Jiang Kuiran Liu |
| author_sort | Manlin Zhang |
| collection | DOAJ |
| description | Endometriosis (EM) is characterized by the existence of endometrial mucosa outside the uterine cavity, which causesinfertility, persistent aches, and a decline in women's quality of life. Both hormone therapies and nonhormone therapies, such as NSAIDs, are ineffective, generic categories of EM drugs. Endometriosis is a benign gynecological condition, yet it shares a number of features with cancer cells, including immune evasion, survival, adhesion, invasion, and angiogenesis. Several endometriosis-related signaling pathways are comprehensively reviewed in this article, including E2, NF-κB, MAPK, ERK, PI3K/Akt/mTOR, YAP, Wnt/β‐catenin, Rho/ROCK, TGF‐β, VEGF, NO, iron, cytokines and chemokines. To find and develop novel medications for the treatment of EM, it is essential to implicitly determine the molecular pathways that are disordered during EM development. Additionally, research on the shared pathways between EM and tumors can provide hypotheses or suggestions for endometriosis therapeutic targets. |
| first_indexed | 2024-03-13T04:56:56Z |
| format | Article |
| id | doaj.art-a52eafd21cab4d2d9851abfc403312da |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-03-13T04:56:56Z |
| publishDate | 2023-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-a52eafd21cab4d2d9851abfc403312da2023-06-18T05:00:39ZengElsevierBiomedicine & Pharmacotherapy0753-33222023-08-01164114909Research advances in endometriosis-related signaling pathways: A reviewManlin Zhang0Tongtong Xu1Deming Tong2Siman Li3Xiaodan Yu4Boya Liu5Lili Jiang6Kuiran Liu7Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, ChinaDepartment of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, ChinaDepartment of General Surgery, General Hospital of Northern Theater Command, Shenyang, ChinaDepartment of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, ChinaDepartment of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, ChinaDepartment of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, ChinaDepartment of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China; Corresponding authors.Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China; Corresponding authors.Endometriosis (EM) is characterized by the existence of endometrial mucosa outside the uterine cavity, which causesinfertility, persistent aches, and a decline in women's quality of life. Both hormone therapies and nonhormone therapies, such as NSAIDs, are ineffective, generic categories of EM drugs. Endometriosis is a benign gynecological condition, yet it shares a number of features with cancer cells, including immune evasion, survival, adhesion, invasion, and angiogenesis. Several endometriosis-related signaling pathways are comprehensively reviewed in this article, including E2, NF-κB, MAPK, ERK, PI3K/Akt/mTOR, YAP, Wnt/β‐catenin, Rho/ROCK, TGF‐β, VEGF, NO, iron, cytokines and chemokines. To find and develop novel medications for the treatment of EM, it is essential to implicitly determine the molecular pathways that are disordered during EM development. Additionally, research on the shared pathways between EM and tumors can provide hypotheses or suggestions for endometriosis therapeutic targets.http://www.sciencedirect.com/science/article/pii/S0753332223006996EndometriosisPathophysiologyPathwaysTargets |
| spellingShingle | Manlin Zhang Tongtong Xu Deming Tong Siman Li Xiaodan Yu Boya Liu Lili Jiang Kuiran Liu Research advances in endometriosis-related signaling pathways: A review Biomedicine & Pharmacotherapy Endometriosis Pathophysiology Pathways Targets |
| title | Research advances in endometriosis-related signaling pathways: A review |
| title_full | Research advances in endometriosis-related signaling pathways: A review |
| title_fullStr | Research advances in endometriosis-related signaling pathways: A review |
| title_full_unstemmed | Research advances in endometriosis-related signaling pathways: A review |
| title_short | Research advances in endometriosis-related signaling pathways: A review |
| title_sort | research advances in endometriosis related signaling pathways a review |
| topic | Endometriosis Pathophysiology Pathways Targets |
| url | http://www.sciencedirect.com/science/article/pii/S0753332223006996 |
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