The Chemically Synthesized Ageladine A-Derivative LysoGlow84 Stains Lysosomes in Viable Mammalian Brain Cells and Specific Structures in the Marine Flatworm Macrostomum lignano

The Chemically Synthesized Ageladine A-Derivative LysoGlow84 Stains Lysosomes in Viable Mammalian Brain Cells and Specific Structures in the Marine Flatworm Macrostomum lignano

Based on the chemical structure and the known chemical synthesis of the marine sponge alkaloid ageladine A, we synthesized the ageladine A-derivative 4-(naphthalene-2-yl)-1H-imidazo[4,5-c]pyridine trifluoroacetate (LysoGlow84). The two-step synthesis started with the Pictet-Spengler reaction of hist...

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Bibliographic Details
Main Authors: Thorsten Mordhorst, Sushil Awal, Sebastian Jordan, Charlotte Petters, Linda Sartoris, Ralf Dringen, Ulf Bickmeyer
Format: Article
Language:English
Published: MDPI AG 2015-02-01
Series:Marine Drugs
Subjects:
ageladine A derivative
fluorescence
live imaging
lysosomes
new dye
Online Access:http://www.mdpi.com/1660-3397/13/2/920

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