A sonosensitiser‐based polymeric nanoplatform for chemo‐sonodynamic combination therapy of lung cancer
Abstract Background Lung cancer is the most common type of tumour worldwide. Its relative lethality is considerably high. However, since the tumour tissues are located deep within the human body, traditional technologies, such as photodynamic therapy, do not have the desired effect. Sonosensitisers...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-02-01
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| Series: | Journal of Nanobiotechnology |
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| Online Access: | https://doi.org/10.1186/s12951-021-00804-9 |
| _version_ | 1811212525152239616 |
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| author | Yanan Zhang Abdur Rauf Khan Xiaoye Yang Yikang Shi Xiaogang Zhao Guangxi Zhai |
| author_facet | Yanan Zhang Abdur Rauf Khan Xiaoye Yang Yikang Shi Xiaogang Zhao Guangxi Zhai |
| author_sort | Yanan Zhang |
| collection | DOAJ |
| description | Abstract Background Lung cancer is the most common type of tumour worldwide. Its relative lethality is considerably high. However, since the tumour tissues are located deep within the human body, traditional technologies, such as photodynamic therapy, do not have the desired effect. Sonosensitisers can penetrate deeply into tissues, and sonodynamic therapy (SDT) effectively inhibits tumours by generating reactive oxygen species. Ultrasound can also penetrate deeply, with a favourable tumour inhibition effect. Results A redox/ultrasound-responsive Rhein-chondroitin sulphate-based nano-preparation encapsulating docetaxel was fabricated. The nanoparticles displayed increased cellular uptake with quick drug release, good stability, and a monodispersed form in the physiological environment. Rhein induced apoptosis and altered mitochondrial membrane potential, which enhanced the expression of apoptosis-related proteins. SDT inhibited the metastasis and angiogenesis of cancer cells and activated anti-tumour capacity by reducing the expression of M2 macrophages. Conclusions The potential of Rhein for SDT was demonstrated. Production of reaction oxygen species was markedly enhanced after ultrasound treatment. The nanoplatform enhanced the synergistic anti-tumour effects of SDT and chemotherapeutic efficacy. The approach was biocompatibility. The findings could inform investigations of chemo-SDT for different cancers. |
| first_indexed | 2024-04-12T05:30:20Z |
| format | Article |
| id | doaj.art-a5325523dba24964b02c52f59403c364 |
| institution | Directory Open Access Journal |
| issn | 1477-3155 |
| language | English |
| last_indexed | 2024-04-12T05:30:20Z |
| publishDate | 2021-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj.art-a5325523dba24964b02c52f59403c3642022-12-22T03:46:06ZengBMCJournal of Nanobiotechnology1477-31552021-02-0119111710.1186/s12951-021-00804-9A sonosensitiser‐based polymeric nanoplatform for chemo‐sonodynamic combination therapy of lung cancerYanan Zhang0Abdur Rauf Khan1Xiaoye Yang2Yikang Shi3Xiaogang Zhao4Guangxi Zhai5Department of Pharmaceutics, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong UniversityDepartment of Pharmaceutics, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong UniversityDepartment of Pharmaceutics, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong UniversityNational Glycoengineering Research Center, Shandong UniversityDepartment of Thoracic Surgery, The Second Hospital of Shandong UniversityDepartment of Pharmaceutics, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong UniversityAbstract Background Lung cancer is the most common type of tumour worldwide. Its relative lethality is considerably high. However, since the tumour tissues are located deep within the human body, traditional technologies, such as photodynamic therapy, do not have the desired effect. Sonosensitisers can penetrate deeply into tissues, and sonodynamic therapy (SDT) effectively inhibits tumours by generating reactive oxygen species. Ultrasound can also penetrate deeply, with a favourable tumour inhibition effect. Results A redox/ultrasound-responsive Rhein-chondroitin sulphate-based nano-preparation encapsulating docetaxel was fabricated. The nanoparticles displayed increased cellular uptake with quick drug release, good stability, and a monodispersed form in the physiological environment. Rhein induced apoptosis and altered mitochondrial membrane potential, which enhanced the expression of apoptosis-related proteins. SDT inhibited the metastasis and angiogenesis of cancer cells and activated anti-tumour capacity by reducing the expression of M2 macrophages. Conclusions The potential of Rhein for SDT was demonstrated. Production of reaction oxygen species was markedly enhanced after ultrasound treatment. The nanoplatform enhanced the synergistic anti-tumour effects of SDT and chemotherapeutic efficacy. The approach was biocompatibility. The findings could inform investigations of chemo-SDT for different cancers.https://doi.org/10.1186/s12951-021-00804-9Chemo-sonodynamic therapyRheinRedox/ultrasound-responsiveReactive oxygen speciesMacrophages |
| spellingShingle | Yanan Zhang Abdur Rauf Khan Xiaoye Yang Yikang Shi Xiaogang Zhao Guangxi Zhai A sonosensitiser‐based polymeric nanoplatform for chemo‐sonodynamic combination therapy of lung cancer Journal of Nanobiotechnology Chemo-sonodynamic therapy Rhein Redox/ultrasound-responsive Reactive oxygen species Macrophages |
| title | A sonosensitiser‐based polymeric nanoplatform for chemo‐sonodynamic combination therapy of lung cancer |
| title_full | A sonosensitiser‐based polymeric nanoplatform for chemo‐sonodynamic combination therapy of lung cancer |
| title_fullStr | A sonosensitiser‐based polymeric nanoplatform for chemo‐sonodynamic combination therapy of lung cancer |
| title_full_unstemmed | A sonosensitiser‐based polymeric nanoplatform for chemo‐sonodynamic combination therapy of lung cancer |
| title_short | A sonosensitiser‐based polymeric nanoplatform for chemo‐sonodynamic combination therapy of lung cancer |
| title_sort | sonosensitiser based polymeric nanoplatform for chemo sonodynamic combination therapy of lung cancer |
| topic | Chemo-sonodynamic therapy Rhein Redox/ultrasound-responsive Reactive oxygen species Macrophages |
| url | https://doi.org/10.1186/s12951-021-00804-9 |
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