The Fat Mass and Obesity-Associated Protein (FTO) Regulates Locomotor Responses to Novelty via D2R Medium Spiny Neurons

The Fat Mass and Obesity-Associated Protein (FTO) Regulates Locomotor Responses to Novelty via D2R Medium Spiny Neurons

Summary: Variations in the human FTO gene have been linked to obesity and altered connectivity of the dopaminergic neurocircuitry. Here, we report that fat mass and obesity-associated protein (FTO) in dopamine D2 receptor-expressing medium spiny neurons (D2 MSNs) of mice regulate the excitability of...

Full description

Bibliographic Details
Main Authors: Johan Ruud, Jens Alber, Anna Tokarska, Linda Engström Ruud, Hendrik Nolte, Nasim Biglari, Rachel Lippert, Änne Lautenschlager, Przemysław E. Cieślak, Łukasz Szumiec, Martin E. Hess, Hella S. Brönneke, Marcus Krüger, Hans Nissbrandt, Tatiana Korotkova, Gilad Silberberg, Jan Rodriguez Parkitna, Jens C. Brüning
Format: Article
Language:English
Published: Elsevier 2019-06-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124719306576

Similar Items

Similar Items