CUL4B mutations impair human cortical neurogenesis through PP2A-dependent inhibition of AKT and ERK

CUL4B mutations impair human cortical neurogenesis through PP2A-dependent inhibition of AKT and ERK

Abstract Mutation in CUL4B gene is one of the most common causes for X-linked intellectual disability (XLID). CUL4B is the scaffold protein in CUL4B-RING ubiquitin ligase (CRL4B) complex. While the roles of CUL4B in cancer progression and some developmental processes like adipogenesis, osteogenesis,...

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Bibliographic Details
Main Authors: Yanyan Ma, Xiaolin Liu, Min Zhou, Wenjie Sun, Baichun Jiang, Qiao Liu, Molin Wang, Yongxin Zou, Qiji Liu, Yaoqin Gong, Gongping Sun
Format: Article
Language:English
Published: Nature Publishing Group 2024-02-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-024-06501-3

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https://doi.org/10.1038/s41419-024-06501-3

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