Case series: Continued remission of PTSD symptoms after discontinuation of prazosin
Post-traumatic stress disorder is a debilitating chronic illness that affects 6 out of 100 adults after a severe trauma. The alpha-adrenergic antagonist prazosin, which is prescribed off-label for flashbacks and nightmares due to trauma, is often continued indefinitely due to reports of symptoms ret...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-04-01
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| Series: | Frontiers in Psychiatry |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1172754/full |
| _version_ | 1797843259369717760 |
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| author | Christie Richardson Jonathan Yuh Jing Su Martin Forsberg |
| author_facet | Christie Richardson Jonathan Yuh Jing Su Martin Forsberg |
| author_sort | Christie Richardson |
| collection | DOAJ |
| description | Post-traumatic stress disorder is a debilitating chronic illness that affects 6 out of 100 adults after a severe trauma. The alpha-adrenergic antagonist prazosin, which is prescribed off-label for flashbacks and nightmares due to trauma, is often continued indefinitely due to reports of symptoms returning upon discontinuation. There is no standard guidance for a trial of discontinuation of prazosin due to intolerance or side effects. In this case series, three patients are started on prazosin leading to remission of trauma-related symptoms, and symptoms continue to remit after treatment for an average of about 2 years followed by discontinuation of the medication. There are many similarities in these case reports which serve to provide guidance as to when a trial of prazosin discontinuation may be warranted. |
| first_indexed | 2024-04-09T17:02:16Z |
| format | Article |
| id | doaj.art-a5395c65a86647a9a4e228f6e07fe861 |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-04-09T17:02:16Z |
| publishDate | 2023-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-a5395c65a86647a9a4e228f6e07fe8612023-04-21T04:26:08ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402023-04-011410.3389/fpsyt.2023.11727541172754Case series: Continued remission of PTSD symptoms after discontinuation of prazosinChristie RichardsonJonathan YuhJing SuMartin ForsbergPost-traumatic stress disorder is a debilitating chronic illness that affects 6 out of 100 adults after a severe trauma. The alpha-adrenergic antagonist prazosin, which is prescribed off-label for flashbacks and nightmares due to trauma, is often continued indefinitely due to reports of symptoms returning upon discontinuation. There is no standard guidance for a trial of discontinuation of prazosin due to intolerance or side effects. In this case series, three patients are started on prazosin leading to remission of trauma-related symptoms, and symptoms continue to remit after treatment for an average of about 2 years followed by discontinuation of the medication. There are many similarities in these case reports which serve to provide guidance as to when a trial of prazosin discontinuation may be warranted.https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1172754/fullpost-traumatic stress disorderprazosintraumanightmaresflashbackspsychopharmacology |
| spellingShingle | Christie Richardson Jonathan Yuh Jing Su Martin Forsberg Case series: Continued remission of PTSD symptoms after discontinuation of prazosin Frontiers in Psychiatry post-traumatic stress disorder prazosin trauma nightmares flashbacks psychopharmacology |
| title | Case series: Continued remission of PTSD symptoms after discontinuation of prazosin |
| title_full | Case series: Continued remission of PTSD symptoms after discontinuation of prazosin |
| title_fullStr | Case series: Continued remission of PTSD symptoms after discontinuation of prazosin |
| title_full_unstemmed | Case series: Continued remission of PTSD symptoms after discontinuation of prazosin |
| title_short | Case series: Continued remission of PTSD symptoms after discontinuation of prazosin |
| title_sort | case series continued remission of ptsd symptoms after discontinuation of prazosin |
| topic | post-traumatic stress disorder prazosin trauma nightmares flashbacks psychopharmacology |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1172754/full |
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