Evaluation of Multiple Prognostic Factors of Hepatocellular Carcinoma with Intra-Voxel Incoherent Motions Imaging by Extracting the Histogram Metrics
Gaofeng Shi,1,* Xue Han,1,* Qi Wang,1 Yan Ding,1 Hui Liu,1 Yunfei Zhang,2 Yongming Dai2 1Department of Radiology, Fourth Hospital of Hebei Medical University, Shijiazhuang 050000, People’s Republic of China; 2Department of Research Collaboration Hospital (MRI), Central Research Institute,...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2020-07-01
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| Series: | Cancer Management and Research |
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| Online Access: | https://www.dovepress.com/evaluation-of-multiple-prognostic-factors-of-hepatocellular-carcinoma--peer-reviewed-article-CMAR |
| _version_ | 1818863222921363456 |
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| author | Shi G Han X Wang Q Ding Y Liu H Zhang Y Dai Y |
| author_facet | Shi G Han X Wang Q Ding Y Liu H Zhang Y Dai Y |
| author_sort | Shi G |
| collection | DOAJ |
| description | Gaofeng Shi,1,* Xue Han,1,* Qi Wang,1 Yan Ding,1 Hui Liu,1 Yunfei Zhang,2 Yongming Dai2 1Department of Radiology, Fourth Hospital of Hebei Medical University, Shijiazhuang 050000, People’s Republic of China; 2Department of Research Collaboration Hospital (MRI), Central Research Institute, United Imaging Healthcare, Shanghai 201800, People’s Republic of China*These authors contributed equally to this workCorrespondence: Hui Liu; Yunfei Zhang Tel +86-311-86095716; Tel +86-311-86095716Fax +86-311-8609-5692Email liuhui_lh111@163.com yunfei.zhang@united-imaging.comPurpose: To predict multiple prognostic factors of HCC including histopathologic grade, the expression of Ki67 as well as capsule formation with intravoxel incoherent motions imaging by extracting the histogram metrics.Patients and Methods: A total of 52 patients with HCC were recruited with the MR examinations undertaken at a 3T scanner. Histogram metrics were extracted from IVIM-derived parametric maps. Independent student t-test was performed to explore the differences in metrics across different subtypes of prognostic factors. Spearman correlation test was utilized to evaluate the correlations between the IVIM metrics and prognostic factors. ROC analysis was applied to evaluate the diagnostic performance.Results: According to the independent student t-test, there were 18, 4, and 8 IVIM-derived histogram metrics showing the capability for differentiating the subtypes of histopathologic grade, Ki67, and capsule formation, respectively, with P-values of less than 0.05. Besides, there existed a lot of significant correlations between IVIM metrics and prognostic factors. Finally, by integrating different histogram metrics showing significant differences between various subgroups together via establishing logistic regression based diagnostic models, greatest diagnostic power was obtained for grading HCC (AUC=0.917), diagnosing patients with highly expressed Ki67 (AUC=0.861) and diagnosing patients with capsule formation (AUC=0.839).Conclusion: Multiple prognostic factors including histopathologic grade, Ki67 expression status, and capsule formation can be accurately predicted with assistance of histogram metrics sourced from a single IVIM scan.Keywords: diffusion magnetic resonance imaging, intravoxel incoherent motions, hepatocellular carcinoma, prognostic factors, histogram analysis |
| first_indexed | 2024-12-19T10:12:20Z |
| format | Article |
| id | doaj.art-a5401212446c4d4983a6fa4d44c58f2c |
| institution | Directory Open Access Journal |
| issn | 1179-1322 |
| language | English |
| last_indexed | 2024-12-19T10:12:20Z |
| publishDate | 2020-07-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Cancer Management and Research |
| spelling | doaj.art-a5401212446c4d4983a6fa4d44c58f2c2022-12-21T20:26:19ZengDove Medical PressCancer Management and Research1179-13222020-07-01Volume 126019603155479Evaluation of Multiple Prognostic Factors of Hepatocellular Carcinoma with Intra-Voxel Incoherent Motions Imaging by Extracting the Histogram MetricsShi GHan XWang QDing YLiu HZhang YDai YGaofeng Shi,1,* Xue Han,1,* Qi Wang,1 Yan Ding,1 Hui Liu,1 Yunfei Zhang,2 Yongming Dai2 1Department of Radiology, Fourth Hospital of Hebei Medical University, Shijiazhuang 050000, People’s Republic of China; 2Department of Research Collaboration Hospital (MRI), Central Research Institute, United Imaging Healthcare, Shanghai 201800, People’s Republic of China*These authors contributed equally to this workCorrespondence: Hui Liu; Yunfei Zhang Tel +86-311-86095716; Tel +86-311-86095716Fax +86-311-8609-5692Email liuhui_lh111@163.com yunfei.zhang@united-imaging.comPurpose: To predict multiple prognostic factors of HCC including histopathologic grade, the expression of Ki67 as well as capsule formation with intravoxel incoherent motions imaging by extracting the histogram metrics.Patients and Methods: A total of 52 patients with HCC were recruited with the MR examinations undertaken at a 3T scanner. Histogram metrics were extracted from IVIM-derived parametric maps. Independent student t-test was performed to explore the differences in metrics across different subtypes of prognostic factors. Spearman correlation test was utilized to evaluate the correlations between the IVIM metrics and prognostic factors. ROC analysis was applied to evaluate the diagnostic performance.Results: According to the independent student t-test, there were 18, 4, and 8 IVIM-derived histogram metrics showing the capability for differentiating the subtypes of histopathologic grade, Ki67, and capsule formation, respectively, with P-values of less than 0.05. Besides, there existed a lot of significant correlations between IVIM metrics and prognostic factors. Finally, by integrating different histogram metrics showing significant differences between various subgroups together via establishing logistic regression based diagnostic models, greatest diagnostic power was obtained for grading HCC (AUC=0.917), diagnosing patients with highly expressed Ki67 (AUC=0.861) and diagnosing patients with capsule formation (AUC=0.839).Conclusion: Multiple prognostic factors including histopathologic grade, Ki67 expression status, and capsule formation can be accurately predicted with assistance of histogram metrics sourced from a single IVIM scan.Keywords: diffusion magnetic resonance imaging, intravoxel incoherent motions, hepatocellular carcinoma, prognostic factors, histogram analysishttps://www.dovepress.com/evaluation-of-multiple-prognostic-factors-of-hepatocellular-carcinoma--peer-reviewed-article-CMARdiffusion magnetic resonance imagingintravoxel incoherent motionshepatocellular carcinomaprognostic factorshistogram analysis |
| spellingShingle | Shi G Han X Wang Q Ding Y Liu H Zhang Y Dai Y Evaluation of Multiple Prognostic Factors of Hepatocellular Carcinoma with Intra-Voxel Incoherent Motions Imaging by Extracting the Histogram Metrics Cancer Management and Research diffusion magnetic resonance imaging intravoxel incoherent motions hepatocellular carcinoma prognostic factors histogram analysis |
| title | Evaluation of Multiple Prognostic Factors of Hepatocellular Carcinoma with Intra-Voxel Incoherent Motions Imaging by Extracting the Histogram Metrics |
| title_full | Evaluation of Multiple Prognostic Factors of Hepatocellular Carcinoma with Intra-Voxel Incoherent Motions Imaging by Extracting the Histogram Metrics |
| title_fullStr | Evaluation of Multiple Prognostic Factors of Hepatocellular Carcinoma with Intra-Voxel Incoherent Motions Imaging by Extracting the Histogram Metrics |
| title_full_unstemmed | Evaluation of Multiple Prognostic Factors of Hepatocellular Carcinoma with Intra-Voxel Incoherent Motions Imaging by Extracting the Histogram Metrics |
| title_short | Evaluation of Multiple Prognostic Factors of Hepatocellular Carcinoma with Intra-Voxel Incoherent Motions Imaging by Extracting the Histogram Metrics |
| title_sort | evaluation of multiple prognostic factors of hepatocellular carcinoma with intra voxel incoherent motions imaging by extracting the histogram metrics |
| topic | diffusion magnetic resonance imaging intravoxel incoherent motions hepatocellular carcinoma prognostic factors histogram analysis |
| url | https://www.dovepress.com/evaluation-of-multiple-prognostic-factors-of-hepatocellular-carcinoma--peer-reviewed-article-CMAR |
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