Hypotensive Action of Pomegranate Seed Extract and Zinc Chloride in Hypertensive Rats
This study investigated the effects of pomegranate seed extract and supplementary zinc chloride (ZnCl2) on Dexamethasone (DEX) and NaCl induced hypertension in rats. For this purpose, female albino rats were divided into five groups: control and four DEX and NaCl induced hypertensive rats. The anima...
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| Format: | Article |
| Language: | English |
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Salahaddin University-Erbil
2019-10-01
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| Series: | Zanco Journal of Pure and Applied Sciences |
| Subjects: | |
| Online Access: | https://zancojournals.su.edu.krd/index.php/JPAS/article/view/2501 |
| _version_ | 1811274177241415680 |
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| author | Zana Rafiq Majeed Firas Khalid Qasim Hedy Ahmed Hassan |
| author_facet | Zana Rafiq Majeed Firas Khalid Qasim Hedy Ahmed Hassan |
| author_sort | Zana Rafiq Majeed |
| collection | DOAJ |
| description | This study investigated the effects of pomegranate seed extract and supplementary zinc chloride (ZnCl2) on Dexamethasone (DEX) and NaCl induced hypertension in rats. For this purpose, female albino rats were divided into five groups: control and four DEX and NaCl induced hypertensive rats. The animals were given pomegranate seed extract, ZnCl2, or a combination of both for two weeks. Our results show a significant decrease in systolic blood pressure (SBP) in each of the treated groups, except the combination group. DEX and NaCl combination significantly decreased the total body weight in rats. The body weight was not changed with pomegranate seed extract or ZnCl2 administration. Besides WBC, RBC, HGB, HCT, and PLTs levels were not altered. There were no significant differences in the levels of serum K+, Ca2+, and Cl- ions among the treated groups. Nevertheless, the Na+ level in the serum increased significantly in rats of the combination group. Taken together, we conclude that pomegranate seed extract and ZnCl2 consumption can be beneficial for lowering blood pressure in hypertensive patients when consumed separately. |
| first_indexed | 2024-04-12T23:14:11Z |
| format | Article |
| id | doaj.art-a5404f652ce3493f8a72b7e4c607102f |
| institution | Directory Open Access Journal |
| issn | 2218-0230 2412-3986 |
| language | English |
| last_indexed | 2024-04-12T23:14:11Z |
| publishDate | 2019-10-01 |
| publisher | Salahaddin University-Erbil |
| record_format | Article |
| series | Zanco Journal of Pure and Applied Sciences |
| spelling | doaj.art-a5404f652ce3493f8a72b7e4c607102f2022-12-22T03:12:44ZengSalahaddin University-ErbilZanco Journal of Pure and Applied Sciences2218-02302412-39862019-10-01315445210.21271/zjpas.31.5.6Hypotensive Action of Pomegranate Seed Extract and Zinc Chloride in Hypertensive RatsZana Rafiq Majeed0Firas Khalid Qasim1Hedy Ahmed Hassan2Department of Biology, College of Science, Salahaddin University-Erbil, Erbil, Kurdistan Region, Iraq.Department of Biology, College of Science, Salahaddin University-Erbil, Erbil, Kurdistan Region, Iraq.Department of Biology, College of Science, Salahaddin University-Erbil, Erbil, Kurdistan Region, Iraq.This study investigated the effects of pomegranate seed extract and supplementary zinc chloride (ZnCl2) on Dexamethasone (DEX) and NaCl induced hypertension in rats. For this purpose, female albino rats were divided into five groups: control and four DEX and NaCl induced hypertensive rats. The animals were given pomegranate seed extract, ZnCl2, or a combination of both for two weeks. Our results show a significant decrease in systolic blood pressure (SBP) in each of the treated groups, except the combination group. DEX and NaCl combination significantly decreased the total body weight in rats. The body weight was not changed with pomegranate seed extract or ZnCl2 administration. Besides WBC, RBC, HGB, HCT, and PLTs levels were not altered. There were no significant differences in the levels of serum K+, Ca2+, and Cl- ions among the treated groups. Nevertheless, the Na+ level in the serum increased significantly in rats of the combination group. Taken together, we conclude that pomegranate seed extract and ZnCl2 consumption can be beneficial for lowering blood pressure in hypertensive patients when consumed separately.https://zancojournals.su.edu.krd/index.php/JPAS/article/view/2501Pomegranate; zinc chloride; toxicity; hypertension; blood parameters |
| spellingShingle | Zana Rafiq Majeed Firas Khalid Qasim Hedy Ahmed Hassan Hypotensive Action of Pomegranate Seed Extract and Zinc Chloride in Hypertensive Rats Zanco Journal of Pure and Applied Sciences Pomegranate; zinc chloride; toxicity; hypertension; blood parameters |
| title | Hypotensive Action of Pomegranate Seed Extract and Zinc Chloride in Hypertensive Rats |
| title_full | Hypotensive Action of Pomegranate Seed Extract and Zinc Chloride in Hypertensive Rats |
| title_fullStr | Hypotensive Action of Pomegranate Seed Extract and Zinc Chloride in Hypertensive Rats |
| title_full_unstemmed | Hypotensive Action of Pomegranate Seed Extract and Zinc Chloride in Hypertensive Rats |
| title_short | Hypotensive Action of Pomegranate Seed Extract and Zinc Chloride in Hypertensive Rats |
| title_sort | hypotensive action of pomegranate seed extract and zinc chloride in hypertensive rats |
| topic | Pomegranate; zinc chloride; toxicity; hypertension; blood parameters |
| url | https://zancojournals.su.edu.krd/index.php/JPAS/article/view/2501 |
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