Recent advances in selective photothermal therapy of tumor
Abstract Photothermal therapy (PTT), which converts light energy to heat energy, has become a new research hotspot in cancer treatment. Although researchers have investigated various ways to improve the efficiency of tumor heat ablation to treat cancer, PTT may cause severe damage to normal tissue d...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-10-01
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| Series: | Journal of Nanobiotechnology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12951-021-01080-3 |
| _version_ | 1817994628054384640 |
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| author | Liping Zhao Xu Zhang Xiaoxia Wang Xiuwen Guan Weifeng Zhang Jinlong Ma |
| author_facet | Liping Zhao Xu Zhang Xiaoxia Wang Xiuwen Guan Weifeng Zhang Jinlong Ma |
| author_sort | Liping Zhao |
| collection | DOAJ |
| description | Abstract Photothermal therapy (PTT), which converts light energy to heat energy, has become a new research hotspot in cancer treatment. Although researchers have investigated various ways to improve the efficiency of tumor heat ablation to treat cancer, PTT may cause severe damage to normal tissue due to the systemic distribution of photothermal agents (PTAs) in the body and inaccurate laser exposure during treatment. To further improve the survival rate of cancer patients and reduce possible side effects on other parts of the body, it is still necessary to explore PTAs with high selectivity and precise treatment. In this review, we summarized strategies to improve the treatment selectivity of PTT, such as increasing the accumulation of PTAs at tumor sites and endowing PTAs with a self-regulating photothermal conversion function. The views and challenges of selective PTT were discussed, especially the prospects and challenges of their clinical applications. |
| first_indexed | 2024-04-14T01:54:37Z |
| format | Article |
| id | doaj.art-a541424e0a654670a983b3516bc987c0 |
| institution | Directory Open Access Journal |
| issn | 1477-3155 |
| language | English |
| last_indexed | 2024-04-14T01:54:37Z |
| publishDate | 2021-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj.art-a541424e0a654670a983b3516bc987c02022-12-22T02:19:08ZengBMCJournal of Nanobiotechnology1477-31552021-10-0119111510.1186/s12951-021-01080-3Recent advances in selective photothermal therapy of tumorLiping Zhao0Xu Zhang1Xiaoxia Wang2Xiuwen Guan3Weifeng Zhang4Jinlong Ma5College of Pharmacy, Weifang Medical UniversitySchool of Clinical Medicine, Weifang Medical UniversityCollege of Pharmacy, Weifang Medical UniversityCollege of Pharmacy, Weifang Medical UniversityCollege of Pharmacy, Weifang Medical UniversityCollege of Pharmacy, Weifang Medical UniversityAbstract Photothermal therapy (PTT), which converts light energy to heat energy, has become a new research hotspot in cancer treatment. Although researchers have investigated various ways to improve the efficiency of tumor heat ablation to treat cancer, PTT may cause severe damage to normal tissue due to the systemic distribution of photothermal agents (PTAs) in the body and inaccurate laser exposure during treatment. To further improve the survival rate of cancer patients and reduce possible side effects on other parts of the body, it is still necessary to explore PTAs with high selectivity and precise treatment. In this review, we summarized strategies to improve the treatment selectivity of PTT, such as increasing the accumulation of PTAs at tumor sites and endowing PTAs with a self-regulating photothermal conversion function. The views and challenges of selective PTT were discussed, especially the prospects and challenges of their clinical applications.https://doi.org/10.1186/s12951-021-01080-3Photothermal therapySelective killingTargeted enrichmentSelf-regulating |
| spellingShingle | Liping Zhao Xu Zhang Xiaoxia Wang Xiuwen Guan Weifeng Zhang Jinlong Ma Recent advances in selective photothermal therapy of tumor Journal of Nanobiotechnology Photothermal therapy Selective killing Targeted enrichment Self-regulating |
| title | Recent advances in selective photothermal therapy of tumor |
| title_full | Recent advances in selective photothermal therapy of tumor |
| title_fullStr | Recent advances in selective photothermal therapy of tumor |
| title_full_unstemmed | Recent advances in selective photothermal therapy of tumor |
| title_short | Recent advances in selective photothermal therapy of tumor |
| title_sort | recent advances in selective photothermal therapy of tumor |
| topic | Photothermal therapy Selective killing Targeted enrichment Self-regulating |
| url | https://doi.org/10.1186/s12951-021-01080-3 |
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