Role of herpesvirus infection in glomerulonephritis and nephrotic syndrome in children

The paper analyzes the literature on glomerulonephritis and nephrotic syndrome, which are associated with herpesvirus types 1/2, 4, 5, and 7 infection, in children. The main pathogenetic mechanisms and clinical and morphological characteristics of herpesvirusassociated glomerulonephritis and nephrot...

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Bibliographic Details
Main Authors: N. V. Necheporenko, N. D. Savenkova, N. M. Kalinina
Format: Article
Language:Russian
Published: Ltd. “The National Academy of Pediatric Science and Innovation” 2017-04-01
Series:Rossijskij Vestnik Perinatologii i Pediatrii
Subjects:
Online Access:https://www.ped-perinatology.ru/jour/article/view/447
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Summary:The paper analyzes the literature on glomerulonephritis and nephrotic syndrome, which are associated with herpesvirus types 1/2, 4, 5, and 7 infection, in children. The main pathogenetic mechanisms and clinical and morphological characteristics of herpesvirusassociated glomerulonephritis and nephrotic syndrome are considered. These diseases are shown to be frequently accompanied by immune disorders involving innate and adaptive immunity and interferonogenesis. Virus-associated glomerulonephritis and nephrotic syndrome are characterized by transient resistance to therapy with prednisone and cytotoxic agents and by a serious prediction. Clinical and immunological studies have proven that immunostimulatory (interferon-α2) and antiviral (acyclovir, ganciclovir) therapies result in restoration of prednisolone sensitivity and in complete or partial remission of virus-associated glomerulonephritis and idiopathic nephrotic syndrome in children. It is recommended that cytotoxic therapy should be prescribed if there is no activation of herpesvirus (types 1/2, 4, 5) infection, which has been achieved by antiviral and immunostimulatory therapies.
ISSN:1027-4065
2500-2228