Isotretinoin musculoskeletal side effects: a systematic review
This study aimed to investigate musculoskeletal complications secondary to isotretinoin use. A systematic review was conducted, and a total of 49 studies, including analytical studies, case reports, and case series, were included in the analysis. The studies examined musculoskeletal symptoms, diagn...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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PAGEPress Publications
2024-04-01
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| Series: | Dermatology Reports |
| Subjects: | |
| Online Access: | https://www.pagepress.org/journals/dr/article/view/9845 |
| _version_ | 1797213065126608896 |
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| author | Rahaf R. Almutairi Atheer G. Almutairi Afnan F. Alhallafi Norah A. Almudawi Mohammed Abdulaziz AlSulaiman Asem M. Shadid Ruaa Alharithy |
| author_facet | Rahaf R. Almutairi Atheer G. Almutairi Afnan F. Alhallafi Norah A. Almudawi Mohammed Abdulaziz AlSulaiman Asem M. Shadid Ruaa Alharithy |
| author_sort | Rahaf R. Almutairi |
| collection | DOAJ |
| description |
This study aimed to investigate musculoskeletal complications secondary to isotretinoin use. A systematic review was conducted, and a total of 49 studies, including analytical studies, case reports, and case series, were included in the analysis. The studies examined musculoskeletal symptoms, diagnostic findings, and treatment approaches associated with isotretinoin use. Musculoskeletal symptoms reported in the studies included lethargy, myalgia, low back pain, arthralgia, tendinopathy, and sacroiliitis. Physical examination findings and radiological findings were used to confirm the diagnoses. Treatment approaches ranged from [non-steroidal anti-inflammatory drugs (NSAIDs)] to discontinuation of isotretinoin. Some studies have explored the impact of isotretinoin dosage, treatment duration, and vitamin levels on musculoskeletal symptoms. Isotretinoin-induced sacroiliitis and [diffuse idiopathic skeletal hyperostosis (DISH)] emerged as notable musculoskeletal complications. The findings highlight the importance of monitoring patients for potential musculoskeletal side effects and implementing appropriate interventions.
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| first_indexed | 2024-04-24T10:52:21Z |
| format | Article |
| id | doaj.art-a5440754eb464591a42aeead37a832f8 |
| institution | Directory Open Access Journal |
| issn | 2036-7392 2036-7406 |
| language | English |
| last_indexed | 2024-04-24T10:52:21Z |
| publishDate | 2024-04-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Dermatology Reports |
| spelling | doaj.art-a5440754eb464591a42aeead37a832f82024-04-12T10:30:15ZengPAGEPress PublicationsDermatology Reports2036-73922036-74062024-04-0110.4081/dr.2024.9845Isotretinoin musculoskeletal side effects: a systematic reviewRahaf R. Almutairi0Atheer G. Almutairi1Afnan F. Alhallafi2Norah A. Almudawi3Mohammed Abdulaziz AlSulaiman4Asem M. Shadid5Ruaa Alharithy6College of Medicine, Imam Mohammed bin Saud Islamic UniversityUnaizah College of Medicine and Medical Sciences, Qassim University, UnaizahCollege of Medicine, Imam Mohammed bin Saud Islamic UniversityCollege of Medicine, Imam Mohammed bin Saud Islamic UniversityDivision of Dermatology, Security Forces Hospital, RiyadhDepartment of Dermatology, King Fahad Medical CityDivision of Dermatology, Security Forces Hospital, Riyadh; Princess Nourah Bint Abdul Rahman University, Riyadh This study aimed to investigate musculoskeletal complications secondary to isotretinoin use. A systematic review was conducted, and a total of 49 studies, including analytical studies, case reports, and case series, were included in the analysis. The studies examined musculoskeletal symptoms, diagnostic findings, and treatment approaches associated with isotretinoin use. Musculoskeletal symptoms reported in the studies included lethargy, myalgia, low back pain, arthralgia, tendinopathy, and sacroiliitis. Physical examination findings and radiological findings were used to confirm the diagnoses. Treatment approaches ranged from [non-steroidal anti-inflammatory drugs (NSAIDs)] to discontinuation of isotretinoin. Some studies have explored the impact of isotretinoin dosage, treatment duration, and vitamin levels on musculoskeletal symptoms. Isotretinoin-induced sacroiliitis and [diffuse idiopathic skeletal hyperostosis (DISH)] emerged as notable musculoskeletal complications. The findings highlight the importance of monitoring patients for potential musculoskeletal side effects and implementing appropriate interventions. https://www.pagepress.org/journals/dr/article/view/9845Isotretinoinacnemusculoskeletal side effectsarthritismyositis |
| spellingShingle | Rahaf R. Almutairi Atheer G. Almutairi Afnan F. Alhallafi Norah A. Almudawi Mohammed Abdulaziz AlSulaiman Asem M. Shadid Ruaa Alharithy Isotretinoin musculoskeletal side effects: a systematic review Dermatology Reports Isotretinoin acne musculoskeletal side effects arthritis myositis |
| title | Isotretinoin musculoskeletal side effects: a systematic review |
| title_full | Isotretinoin musculoskeletal side effects: a systematic review |
| title_fullStr | Isotretinoin musculoskeletal side effects: a systematic review |
| title_full_unstemmed | Isotretinoin musculoskeletal side effects: a systematic review |
| title_short | Isotretinoin musculoskeletal side effects: a systematic review |
| title_sort | isotretinoin musculoskeletal side effects a systematic review |
| topic | Isotretinoin acne musculoskeletal side effects arthritis myositis |
| url | https://www.pagepress.org/journals/dr/article/view/9845 |
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