Regulation of mRNA translation by MID1: a common mechanism of expanded CAG repeat RNAs

Regulation of mRNA translation by MID1: a common mechanism of expanded CAG repeat RNAs

Expansion of CAG repeats, which code for the disease-causing polyglutamine protein, is a common feature in polyglutamine diseases. RNA-mediated mechanisms that contribute to neuropathology in polyglutamine diseases are important. RNA-toxicity describes a phenomenon by which the mutant CAG repeat RNA...

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Hlavní autoři: Nadine Griesche, Judith Schilling, Stephanie Weber, Marlena Rohm, Verena Pesch, Frank Matthes, Georg Auburger, Sybille Krauss
Médium: Článek
Jazyk:English
Vydáno: Frontiers Media S.A. 2016-10-01
Edice:Frontiers in Cellular Neuroscience
Témata:
RNA-Binding Proteins
RNA-toxicity
CAG repeat expansion
polyglutamine diseases
MID1
On-line přístup:http://journal.frontiersin.org/Journal/10.3389/fncel.2016.00226/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2016.00226/full

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