Positron emission tomography-computed tomography in the management of lung cancer: An update
This communication presents an update on the current role of positron emission tomography-computed tomography (PET-CT) in the various clinical decision-making steps in lung carcinoma. The modality has been reported to be useful in characterizing solitary pulmonary nodules, improving lung cancer stag...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Thieme Medical and Scientific Publishers Pvt. Ltd.
2013-01-01
|
| Series: | South Asian Journal of Cancer |
| Subjects: | |
| Online Access: | http://journal.sajc.org/article.asp?issn=2278-330X;year=2013;volume=2;issue=3;spage=171;epage=178;aulast=Sharma |
| _version_ | 1819060086077652992 |
|---|---|
| author | Punit Sharma Harmandeep Singh Sandip Basu Rakesh Kumar |
| author_facet | Punit Sharma Harmandeep Singh Sandip Basu Rakesh Kumar |
| author_sort | Punit Sharma |
| collection | DOAJ |
| description | This communication presents an update on the current role of positron emission tomography-computed tomography (PET-CT) in the various clinical decision-making steps in lung carcinoma. The modality has been reported to be useful in characterizing solitary pulmonary nodules, improving lung cancer staging, especially for the detection of nodal and metastatic site involvement, guiding therapy, monitoring treatment response, and predicting outcome in non-small cell lung carcinoma (NSCLC). Its role has been more extensively evaluated in NSCLC than small cell lung carcinoma (SCLC). Limitations in FDG PET-CT are encountered in cases of tumor histotypes characterized by low glucose uptake (mucinous forms, bronchioalveolar carcinoma, neuroendocrine tumors), in the assessment of brain metastases (high physiologic 18F-FDG uptake in the brain) and in cases presenting with associated inflammation. The future potentials of newer PET tracers beyond FDG are enumerated. An evolving area is PET-guided assessment of targeted therapy (e.g., EGFR and EGFR tyrosine kinase overexpression) in tumors which have significant potential for drug development. |
| first_indexed | 2024-12-21T14:21:24Z |
| format | Article |
| id | doaj.art-a547e8c15168431f8c02fbefa010a72a |
| institution | Directory Open Access Journal |
| issn | 2278-330X 2278-4306 |
| language | English |
| last_indexed | 2024-12-21T14:21:24Z |
| publishDate | 2013-01-01 |
| publisher | Thieme Medical and Scientific Publishers Pvt. Ltd. |
| record_format | Article |
| series | South Asian Journal of Cancer |
| spelling | doaj.art-a547e8c15168431f8c02fbefa010a72a2022-12-21T19:00:47ZengThieme Medical and Scientific Publishers Pvt. Ltd.South Asian Journal of Cancer2278-330X2278-43062013-01-012317117810.4103/2278-330X.114148Positron emission tomography-computed tomography in the management of lung cancer: An updatePunit SharmaHarmandeep SinghSandip BasuRakesh KumarThis communication presents an update on the current role of positron emission tomography-computed tomography (PET-CT) in the various clinical decision-making steps in lung carcinoma. The modality has been reported to be useful in characterizing solitary pulmonary nodules, improving lung cancer staging, especially for the detection of nodal and metastatic site involvement, guiding therapy, monitoring treatment response, and predicting outcome in non-small cell lung carcinoma (NSCLC). Its role has been more extensively evaluated in NSCLC than small cell lung carcinoma (SCLC). Limitations in FDG PET-CT are encountered in cases of tumor histotypes characterized by low glucose uptake (mucinous forms, bronchioalveolar carcinoma, neuroendocrine tumors), in the assessment of brain metastases (high physiologic 18F-FDG uptake in the brain) and in cases presenting with associated inflammation. The future potentials of newer PET tracers beyond FDG are enumerated. An evolving area is PET-guided assessment of targeted therapy (e.g., EGFR and EGFR tyrosine kinase overexpression) in tumors which have significant potential for drug development.http://journal.sajc.org/article.asp?issn=2278-330X;year=2013;volume=2;issue=3;spage=171;epage=178;aulast=SharmaLung cancerPET-CTstagingrestagingsolitary pulmonary nodule |
| spellingShingle | Punit Sharma Harmandeep Singh Sandip Basu Rakesh Kumar Positron emission tomography-computed tomography in the management of lung cancer: An update South Asian Journal of Cancer Lung cancer PET-CT staging restaging solitary pulmonary nodule |
| title | Positron emission tomography-computed tomography in the management of lung cancer: An update |
| title_full | Positron emission tomography-computed tomography in the management of lung cancer: An update |
| title_fullStr | Positron emission tomography-computed tomography in the management of lung cancer: An update |
| title_full_unstemmed | Positron emission tomography-computed tomography in the management of lung cancer: An update |
| title_short | Positron emission tomography-computed tomography in the management of lung cancer: An update |
| title_sort | positron emission tomography computed tomography in the management of lung cancer an update |
| topic | Lung cancer PET-CT staging restaging solitary pulmonary nodule |
| url | http://journal.sajc.org/article.asp?issn=2278-330X;year=2013;volume=2;issue=3;spage=171;epage=178;aulast=Sharma |
| work_keys_str_mv | AT punitsharma positronemissiontomographycomputedtomographyinthemanagementoflungcanceranupdate AT harmandeepsingh positronemissiontomographycomputedtomographyinthemanagementoflungcanceranupdate AT sandipbasu positronemissiontomographycomputedtomographyinthemanagementoflungcanceranupdate AT rakeshkumar positronemissiontomographycomputedtomographyinthemanagementoflungcanceranupdate |