Risk of childhood trauma exposure and severity of bipolar disorder in Colombia
Abstract Background Bipolar disorder (BD) is higher in developing countries. Childhood trauma exposure is a common environmental risk factor in Colombia and might be associated with a more severe course of bipolar disorder in Low-Middle Income-Countries. We carried out the first case–control study i...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SpringerOpen
2023-02-01
|
| Series: | International Journal of Bipolar Disorders |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40345-023-00289-5 |
| _version_ | 1811166076319301632 |
|---|---|
| author | Hernán Guillen-Burgos Sergio Moreno-Lopez Kaleb Acevedo-Vergara Manuel Pérez-Florez Catherine Pachón-Garcia Juan Francisco Gálvez-Flórez |
| author_facet | Hernán Guillen-Burgos Sergio Moreno-Lopez Kaleb Acevedo-Vergara Manuel Pérez-Florez Catherine Pachón-Garcia Juan Francisco Gálvez-Flórez |
| author_sort | Hernán Guillen-Burgos |
| collection | DOAJ |
| description | Abstract Background Bipolar disorder (BD) is higher in developing countries. Childhood trauma exposure is a common environmental risk factor in Colombia and might be associated with a more severe course of bipolar disorder in Low-Middle Income-Countries. We carried out the first case–control study in Colombia using a structural clinical interview and the Childhood Trauma Questionnaire-Short Form (CTQ-SF) to describe the prevalence and association between trauma exposure during childhood with a severe course of illness (early age onset, rapid cycling, ideation or suicide attempt, or ≥ 3 hospitalization) in a sample of BD patients. Results A total of 114 cases and 191 controls evaluated showed the following results. Cases included 61.4% BD type I and 38.6% BD type II. The median age was 31.5 years (IQR, 75–24) for BD patients and 31 years old (IQR, 38–24) for healthy controls. A higher prevalence of childhood trauma was evidenced in cases compared to controls. Emotional abuse, physical abuse, sexual abuse, physical neglect and emotional neglect evidenced a strong association with severe bipolar disorder (OR = 3.42, p < .001; OR = 4.68, p < .001; OR = 4.30, p = .003; OR = 5.10, p < .001; OR = 5.64, p < .001, respectively). Conclusions This is the first association study between childhood trauma exposure as a higher risk for a severe course of illness in BD patients in Colombian. Our findings highlight the higher prevalence of childhood trauma in bipolar patients and the strong association of childhood trauma with severe bipolar disorder. These findings are relevant for screening and evaluating childhood trauma exposure during the course of BD patients. |
| first_indexed | 2024-04-10T15:47:41Z |
| format | Article |
| id | doaj.art-a54a2bfd8bc24b94a40ae891a49c89cf |
| institution | Directory Open Access Journal |
| issn | 2194-7511 |
| language | English |
| last_indexed | 2024-04-10T15:47:41Z |
| publishDate | 2023-02-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | International Journal of Bipolar Disorders |
| spelling | doaj.art-a54a2bfd8bc24b94a40ae891a49c89cf2023-02-12T12:02:32ZengSpringerOpenInternational Journal of Bipolar Disorders2194-75112023-02-0111111210.1186/s40345-023-00289-5Risk of childhood trauma exposure and severity of bipolar disorder in ColombiaHernán Guillen-Burgos0Sergio Moreno-Lopez1Kaleb Acevedo-Vergara2Manuel Pérez-Florez3Catherine Pachón-Garcia4Juan Francisco Gálvez-Flórez5Center for Clinical and Translational Research, La Misericordia Clinica InternacionalSchool of Medicine, Universidad de Los AndesCenter for Clinical and Translational Research, La Misericordia Clinica InternacionalCenter for Clinical and Translational Research, La Misericordia Clinica InternacionalCenter for Clinical and Translational Research, La Misericordia Clinica InternacionalCenter for Clinical and Translational Research, La Misericordia Clinica InternacionalAbstract Background Bipolar disorder (BD) is higher in developing countries. Childhood trauma exposure is a common environmental risk factor in Colombia and might be associated with a more severe course of bipolar disorder in Low-Middle Income-Countries. We carried out the first case–control study in Colombia using a structural clinical interview and the Childhood Trauma Questionnaire-Short Form (CTQ-SF) to describe the prevalence and association between trauma exposure during childhood with a severe course of illness (early age onset, rapid cycling, ideation or suicide attempt, or ≥ 3 hospitalization) in a sample of BD patients. Results A total of 114 cases and 191 controls evaluated showed the following results. Cases included 61.4% BD type I and 38.6% BD type II. The median age was 31.5 years (IQR, 75–24) for BD patients and 31 years old (IQR, 38–24) for healthy controls. A higher prevalence of childhood trauma was evidenced in cases compared to controls. Emotional abuse, physical abuse, sexual abuse, physical neglect and emotional neglect evidenced a strong association with severe bipolar disorder (OR = 3.42, p < .001; OR = 4.68, p < .001; OR = 4.30, p = .003; OR = 5.10, p < .001; OR = 5.64, p < .001, respectively). Conclusions This is the first association study between childhood trauma exposure as a higher risk for a severe course of illness in BD patients in Colombian. Our findings highlight the higher prevalence of childhood trauma in bipolar patients and the strong association of childhood trauma with severe bipolar disorder. These findings are relevant for screening and evaluating childhood trauma exposure during the course of BD patients.https://doi.org/10.1186/s40345-023-00289-5Case–control studyChildhood traumaTraumatic life eventsSevere bipolar disorder |
| spellingShingle | Hernán Guillen-Burgos Sergio Moreno-Lopez Kaleb Acevedo-Vergara Manuel Pérez-Florez Catherine Pachón-Garcia Juan Francisco Gálvez-Flórez Risk of childhood trauma exposure and severity of bipolar disorder in Colombia International Journal of Bipolar Disorders Case–control study Childhood trauma Traumatic life events Severe bipolar disorder |
| title | Risk of childhood trauma exposure and severity of bipolar disorder in Colombia |
| title_full | Risk of childhood trauma exposure and severity of bipolar disorder in Colombia |
| title_fullStr | Risk of childhood trauma exposure and severity of bipolar disorder in Colombia |
| title_full_unstemmed | Risk of childhood trauma exposure and severity of bipolar disorder in Colombia |
| title_short | Risk of childhood trauma exposure and severity of bipolar disorder in Colombia |
| title_sort | risk of childhood trauma exposure and severity of bipolar disorder in colombia |
| topic | Case–control study Childhood trauma Traumatic life events Severe bipolar disorder |
| url | https://doi.org/10.1186/s40345-023-00289-5 |
| work_keys_str_mv | AT hernanguillenburgos riskofchildhoodtraumaexposureandseverityofbipolardisorderincolombia AT sergiomorenolopez riskofchildhoodtraumaexposureandseverityofbipolardisorderincolombia AT kalebacevedovergara riskofchildhoodtraumaexposureandseverityofbipolardisorderincolombia AT manuelperezflorez riskofchildhoodtraumaexposureandseverityofbipolardisorderincolombia AT catherinepachongarcia riskofchildhoodtraumaexposureandseverityofbipolardisorderincolombia AT juanfranciscogalvezflorez riskofchildhoodtraumaexposureandseverityofbipolardisorderincolombia |