The relationship between apolipoprotein genes polymorphisms and susceptibility to osteonecrosis of the femoral head: a meta-analysis
Abstract Background The objective of this study was to evaluate whether apolipoprotein gene polymorphisms confer susceptibility to osteonecrosis of the femoral head (ONFH). Methods The relevant literature was screened from databases of Pubmed, Embase, Wanfang, Weipu and China National Knowledge Inte...
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| Fformat: | Erthygl |
| Iaith: | English |
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BMC
2018-08-01
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| Cyfres: | Lipids in Health and Disease |
| Pynciau: | |
| Mynediad Ar-lein: | http://link.springer.com/article/10.1186/s12944-018-0827-0 |
| _version_ | 1828917835882037248 |
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| author | Yangquan Hao Hao Guo Zhaochen Xu Handeng Qi Yugui Wang Chao Lu Jie Liu Puwei Yuan |
| author_facet | Yangquan Hao Hao Guo Zhaochen Xu Handeng Qi Yugui Wang Chao Lu Jie Liu Puwei Yuan |
| author_sort | Yangquan Hao |
| collection | DOAJ |
| description | Abstract Background The objective of this study was to evaluate whether apolipoprotein gene polymorphisms confer susceptibility to osteonecrosis of the femoral head (ONFH). Methods The relevant literature was screened from databases of Pubmed, Embase, Wanfang, Weipu and China National Knowledge Internet (CNKI) until May, 2017. In addition, odds ratio (OR) and its corresponding 95% confidence interval (CI) were used as a measure of effect size for calculating effect size. Results Totally, six case-control studies were included in this meta-analysis. It revealed that ApoB-C7623T polymorphism frequency was increased in ONFH group than in control group under three genetic models, including allele model (T vs. C, OR = 4.5149, 95% CI: 1.6968–12.0134); additive model (TC vs. CC, OR = 6.2515, 95% CI: 2.0939–18.6640); and dominant model (TT + TC vs. CC, OR = 5.4998, 95% CI: 1.9246–15.7163). In addition, the increased risk of ONFH were related to ApoA1-rs1799837 polymorphism under additive model (AA vs. GG, OR = 1.4175, 95% CI: 1.0522–1.9096) and recessive model (AA vs. GG + AG, OR = 1.7727, 95% CI: 1.3399–2.3452). However, four ApoB rs1042031, rs693, 3’-VNTR and G12619A polymorphisms under the all genetic models were not associated with susceptibility to ONFH. Conclusion The T allele and TC genotype of ApoB-C7623T and AA genotype of ApoA1-rs1799837 may contribute to increase the risk of ONFH. |
| first_indexed | 2024-12-13T20:58:34Z |
| format | Article |
| id | doaj.art-a54e32dd6bcc41e1a42357cbcb271d07 |
| institution | Directory Open Access Journal |
| issn | 1476-511X |
| language | English |
| last_indexed | 2024-12-13T20:58:34Z |
| publishDate | 2018-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Lipids in Health and Disease |
| spelling | doaj.art-a54e32dd6bcc41e1a42357cbcb271d072022-12-21T23:31:40ZengBMCLipids in Health and Disease1476-511X2018-08-0117111010.1186/s12944-018-0827-0The relationship between apolipoprotein genes polymorphisms and susceptibility to osteonecrosis of the femoral head: a meta-analysisYangquan Hao0Hao Guo1Zhaochen Xu2Handeng Qi3Yugui Wang4Chao Lu5Jie Liu6Puwei Yuan7Department of Osteonecrosis and Joint Reconstruction, Honghui Hospital Xi’an Jiao Tong University Health Science CenterDepartment of Osteonecrosis and Joint Reconstruction, Honghui Hospital Xi’an Jiao Tong University Health Science CenterDepartment of Osteonecrosis and Joint Reconstruction, Honghui Hospital Xi’an Jiao Tong University Health Science CenterShaanxi University of Chinese Medicine, Shiji Ave, Xi’an-Xianyang New Ecomic ZoneShaanxi University of Chinese Medicine, Shiji Ave, Xi’an-Xianyang New Ecomic ZoneDepartment of Osteonecrosis and Joint Reconstruction, Honghui Hospital Xi’an Jiao Tong University Health Science CenterShaanxi University of Chinese Medicine, Shiji Ave, Xi’an-Xianyang New Ecomic ZoneShaanxi University of Chinese Medicine, Shiji Ave, Xi’an-Xianyang New Ecomic ZoneAbstract Background The objective of this study was to evaluate whether apolipoprotein gene polymorphisms confer susceptibility to osteonecrosis of the femoral head (ONFH). Methods The relevant literature was screened from databases of Pubmed, Embase, Wanfang, Weipu and China National Knowledge Internet (CNKI) until May, 2017. In addition, odds ratio (OR) and its corresponding 95% confidence interval (CI) were used as a measure of effect size for calculating effect size. Results Totally, six case-control studies were included in this meta-analysis. It revealed that ApoB-C7623T polymorphism frequency was increased in ONFH group than in control group under three genetic models, including allele model (T vs. C, OR = 4.5149, 95% CI: 1.6968–12.0134); additive model (TC vs. CC, OR = 6.2515, 95% CI: 2.0939–18.6640); and dominant model (TT + TC vs. CC, OR = 5.4998, 95% CI: 1.9246–15.7163). In addition, the increased risk of ONFH were related to ApoA1-rs1799837 polymorphism under additive model (AA vs. GG, OR = 1.4175, 95% CI: 1.0522–1.9096) and recessive model (AA vs. GG + AG, OR = 1.7727, 95% CI: 1.3399–2.3452). However, four ApoB rs1042031, rs693, 3’-VNTR and G12619A polymorphisms under the all genetic models were not associated with susceptibility to ONFH. Conclusion The T allele and TC genotype of ApoB-C7623T and AA genotype of ApoA1-rs1799837 may contribute to increase the risk of ONFH.http://link.springer.com/article/10.1186/s12944-018-0827-0Osteonecrosis of the femoral headApolipoprotein A1Apolipoprotein BPolymorphismGenetic modelMeta-analysis |
| spellingShingle | Yangquan Hao Hao Guo Zhaochen Xu Handeng Qi Yugui Wang Chao Lu Jie Liu Puwei Yuan The relationship between apolipoprotein genes polymorphisms and susceptibility to osteonecrosis of the femoral head: a meta-analysis Lipids in Health and Disease Osteonecrosis of the femoral head Apolipoprotein A1 Apolipoprotein B Polymorphism Genetic model Meta-analysis |
| title | The relationship between apolipoprotein genes polymorphisms and susceptibility to osteonecrosis of the femoral head: a meta-analysis |
| title_full | The relationship between apolipoprotein genes polymorphisms and susceptibility to osteonecrosis of the femoral head: a meta-analysis |
| title_fullStr | The relationship between apolipoprotein genes polymorphisms and susceptibility to osteonecrosis of the femoral head: a meta-analysis |
| title_full_unstemmed | The relationship between apolipoprotein genes polymorphisms and susceptibility to osteonecrosis of the femoral head: a meta-analysis |
| title_short | The relationship between apolipoprotein genes polymorphisms and susceptibility to osteonecrosis of the femoral head: a meta-analysis |
| title_sort | relationship between apolipoprotein genes polymorphisms and susceptibility to osteonecrosis of the femoral head a meta analysis |
| topic | Osteonecrosis of the femoral head Apolipoprotein A1 Apolipoprotein B Polymorphism Genetic model Meta-analysis |
| url | http://link.springer.com/article/10.1186/s12944-018-0827-0 |
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