The Role of Gut Microbiota and Its Produced Metabolites in Obesity, Dyslipidemia, Adipocyte Dysfunction, and Its Interventions
Obesity is becoming an increasing problem worldwide and is often, but not invariably, associated with dyslipidemia. The gut microbiota is increasingly linked to cardiovascular disease, nonalcoholic fatty liver disease, and type 2 diabetes mellitus. However, relatively little focus has been attribute...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-08-01
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| Series: | Metabolites |
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| Online Access: | https://www.mdpi.com/2218-1989/11/8/531 |
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| author | Max S. Z. Zwartjes Victor E. A. Gerdes Max Nieuwdorp |
| author_facet | Max S. Z. Zwartjes Victor E. A. Gerdes Max Nieuwdorp |
| author_sort | Max S. Z. Zwartjes |
| collection | DOAJ |
| description | Obesity is becoming an increasing problem worldwide and is often, but not invariably, associated with dyslipidemia. The gut microbiota is increasingly linked to cardiovascular disease, nonalcoholic fatty liver disease, and type 2 diabetes mellitus. However, relatively little focus has been attributed to the role of gut-microbiota-derived metabolites in the development of dyslipidemia and alterations in lipid metabolism. In this review, we discuss current data involved in these processes and point out the therapeutic potentials. We cover the ability of gut microbiota metabolites to alter lipoprotein lipase action, VLDL secretion, and plasma triglyceride levels, and its effects on reverse cholesterol transport, adipocyte dysfunction, and adipose tissue inflammation. Finally, the current intervention strategies for treatment of obesity and dyslipidemia is addressed with emphasis on the role of gut microbiota metabolites and its ability to predict treatment efficacies. |
| first_indexed | 2024-03-10T08:36:23Z |
| format | Article |
| id | doaj.art-a54fa2496ab94f9eb856c3c85021dce7 |
| institution | Directory Open Access Journal |
| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-03-10T08:36:23Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj.art-a54fa2496ab94f9eb856c3c85021dce72023-11-22T08:39:40ZengMDPI AGMetabolites2218-19892021-08-0111853110.3390/metabo11080531The Role of Gut Microbiota and Its Produced Metabolites in Obesity, Dyslipidemia, Adipocyte Dysfunction, and Its InterventionsMax S. Z. Zwartjes0Victor E. A. Gerdes1Max Nieuwdorp2Department of Experimental Vascular Medicine, Amsterdam University Medical Center, 1105 AZ Amsterdam, The NetherlandsDepartment of Experimental Vascular Medicine, Amsterdam University Medical Center, 1105 AZ Amsterdam, The NetherlandsDepartment of Experimental Vascular Medicine, Amsterdam University Medical Center, 1105 AZ Amsterdam, The NetherlandsObesity is becoming an increasing problem worldwide and is often, but not invariably, associated with dyslipidemia. The gut microbiota is increasingly linked to cardiovascular disease, nonalcoholic fatty liver disease, and type 2 diabetes mellitus. However, relatively little focus has been attributed to the role of gut-microbiota-derived metabolites in the development of dyslipidemia and alterations in lipid metabolism. In this review, we discuss current data involved in these processes and point out the therapeutic potentials. We cover the ability of gut microbiota metabolites to alter lipoprotein lipase action, VLDL secretion, and plasma triglyceride levels, and its effects on reverse cholesterol transport, adipocyte dysfunction, and adipose tissue inflammation. Finally, the current intervention strategies for treatment of obesity and dyslipidemia is addressed with emphasis on the role of gut microbiota metabolites and its ability to predict treatment efficacies.https://www.mdpi.com/2218-1989/11/8/531dyslipidemialipid metabolismobesitygut microbiotametaboliteslipoprotein lipase |
| spellingShingle | Max S. Z. Zwartjes Victor E. A. Gerdes Max Nieuwdorp The Role of Gut Microbiota and Its Produced Metabolites in Obesity, Dyslipidemia, Adipocyte Dysfunction, and Its Interventions Metabolites dyslipidemia lipid metabolism obesity gut microbiota metabolites lipoprotein lipase |
| title | The Role of Gut Microbiota and Its Produced Metabolites in Obesity, Dyslipidemia, Adipocyte Dysfunction, and Its Interventions |
| title_full | The Role of Gut Microbiota and Its Produced Metabolites in Obesity, Dyslipidemia, Adipocyte Dysfunction, and Its Interventions |
| title_fullStr | The Role of Gut Microbiota and Its Produced Metabolites in Obesity, Dyslipidemia, Adipocyte Dysfunction, and Its Interventions |
| title_full_unstemmed | The Role of Gut Microbiota and Its Produced Metabolites in Obesity, Dyslipidemia, Adipocyte Dysfunction, and Its Interventions |
| title_short | The Role of Gut Microbiota and Its Produced Metabolites in Obesity, Dyslipidemia, Adipocyte Dysfunction, and Its Interventions |
| title_sort | role of gut microbiota and its produced metabolites in obesity dyslipidemia adipocyte dysfunction and its interventions |
| topic | dyslipidemia lipid metabolism obesity gut microbiota metabolites lipoprotein lipase |
| url | https://www.mdpi.com/2218-1989/11/8/531 |
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